Bevacizumab and Radiation Therapy for Sarcomas

Inclusion Criteria:

Primary soft tissue sarcoma (STS) or an isolated local recurrence of STS. Open incisional biopsy or core biopsies should be performed within 8 weeks prior to registration
Tumor grade of intermediate or high grade
Tumor must be located on the upper extremity, the lower extremity, trunk, retroperitoneum, or pelvis
Primary tumors must be > 5.0cm in maximal diameter and local recurrence can be any size
18 years of age or older
Zubrod performance status of 0-2
Adequate organ and marrow function

Exclusion Criteria:

Metastatic disease
Pregnant or lactating women
HIV positive patients
Prior treatment with radiation, chemotherapy or biotherapy for this tumor
History or evidence of central nervous system (CNS) disease
Serious, non-healing wound, ulcer, or bone fracture
Clinically significant cardiovascular disease, New York Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, or Grade II or greater peripheral vascular disease within 1 year
History of stroke within the past 6 months
Major surgical procedure or significant traumatic injury within 28 days
Current or recent (within 10 days) use of full-dose oral or parenteral anticoagulants or thrombolytic agents.
Presence of bleeding diathesis or coagulopathy
Proteinuria at baseline or clinically significant impairment of renal function
History of abdominal fistula, gastrointestinal perforation, or inta-abdominal abscess within the past 6 months
Documented history of uncontrolled seizures
Grade 2 or greater sensory neuropathy based upon the NCI CTCAE, version 3.0
Known history of deep vein thrombosis or pulmonary embolus
Known hypercoagulable disorder
History of hepatic cirrhosis or current hepatic dysfunction