Colon Cancer Clinical Trial
Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery
Summary
This is a prospective randomized study of 114 patients. The purpose of this study is to compare the efficacy of two standard methods of analgesia for pain control in patients undergoing elective colon and rectal surgery, as measured by the Numeric Pain Scale (NPS) and by the need for supplemental narcotic analgesics. This study is designed to determine if postoperative pain control by local analgesics delivered through preperitoneally placed ON-Q Silver SoakerTM catheters (CPA) is equivalent to continuous epidural analgesia (CEA).
Full Description
Background Perioperative analgesia is a vital part of the management of patients undergoing colon and rectal surgery, affecting well being and length of hospital stay. Neuraxial anesthetics infused through epidural or spinal catheters have become commonplace pain management agents for patients. These techniques, however, are labor-intensive and expensive. Alternatively, local analgesics may be administered directly to the surgical wound via silver catheters.
Aim Two standard methods of analgesia for pain control for colon and rectal surgery will be evaluated systematically to determine if these two approaches are equivalent in terms of patient pain scores and supplemental narcotic use.
Study Design This is a prospective randomized study of 114 participants undergoing elective colon and rectal surgery at an independent academic medical center. The primary outcomes are post-operative pain control and supplemental narcotic usage.
Other variables of interest
Surgical site infections
The post-operative time to return of bowel function
The hospital expenses/cost differences
Quality of life measured with the SF- 36 questionnaire
Eligibility Criteria
Inclusion Criteria:
Age > = 18 years
Scheduled for elective colon or rectal surgery
Surgical procedure either through open laparotomy or via minimal invasive approach (laparoscopic)
Able to provide informed consent
Able to complete patient questionnaire
Exclusion Criteria:
Documented allergic reaction to morphine, hydromorphone, lidocaine, bupivicaine and/or fentanyl
Contra-indication to placement of epidural catheter (spinal stenosis, spinal fusion, etc)
Urgent surgery precluding epidural catheter placement
Systemic Infection contraindicating epidural catheter placement
Unwillingness to participate in follow up assessments
Prisoners
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
Ann Arbor Michigan, 48106, United States
How clear is this clinincal trial information?

Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.