Colon Cancer Clinical Trial
Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer
Summary
RATIONALE: Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Panitumumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether erlotinib hydrochloride given together with panitumumab is more effective with or without irinotecan in treating patients with metastatic colorectal cancer.
PURPOSE: This randomized phase II trial is studying giving erlotinib hydrochloride together with panitumumab to see how well it works with or without irinotecan hydrochloride as second-line therapy in treating patients with metastatic colorectal cancer.
Full Description
OBJECTIVES:
Primary
Determine the response rate in patients with metastatic colorectal cancer treated with erlotinib hydrochloride and panitumumab with versus without irinotecan hydrochloride as second-line therapy .
Secondary
Determine time to disease progression and time to treatment failure in patients treated with these regimens.
Determine the safety of these regimens in these patients.
Determine the effect of these regimens on downstream targets of EGFR in skin rash associated with pharmacologic EGFR inhibition (exploratory).
Determine the association between KRAS mutations and response to EGFR inhibition (exploratory).
OUTLINE: This is a multicenter study. Patients are stratified according to wild-type Kras tumors ( 6/6 UGT1A1 vs 6/7 UGT1A1), and are randomized to 1 of 2 treatment arms. Patients with wild-type Kras tumor 7/7 UGT1A1 receive treatment in arm III.
Arm I: Patients receive oral erlotinib hydrochloride once daily on days 1-14, panitumumab IV over 30-90 minutes on day 1, and irinotecan hydrochloride IV over 90 minutes on day 1. Treatment repeats every 2 weeks in the absence of disease progression or unacceptable toxicity.
Arm II: Patients receive oral erlotinib hydrochloride once daily on days 1-14 and panitumumab IV over 30-90 minutes on day 1. Treatment repeats every 2 weeks in the absence of disease progression or unacceptable toxicity. Upon disease progression, patients receive irinotecan hydrochloride as in arm I.
Arm III: Patients receive erlotinib hydrochloride and panitumumab as in arm II. Skin biopsies and blood samples may be collected for further analysis.
After completion of study therapy, patients are followed every 6 weeks.
Eligibility Criteria
DISEASE CHARACTERISTICS:
Histologically confirmed colorectal cancer
Metastatic disease
Biopsy of either the primary cancer or metastatic site required
Tumor expressing wild-type Kras mutations
Progressive disease within 3 months after treatment with first-line fluorouracil (5-FU) and oxaliplatin-based chemotherapy OR evidence of metastatic disease within 6 months of completing adjuvant therapy with 5-FU and oxaliplatin
Measurable disease defined as ≥ 1 lesion that can be accurately measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques OR as ≥ 10 mm with spiral CT scan
PATIENT CHARACTERISTICS:
ECOG performance status 0-2
Life expectancy > 6 months
ANC > 1,500/mm^3
Platelet count > 100,000/mm^3
Hemoglobin ≥ 9 g/dL
Creatinine < 1.5 times upper limit of normal (ULN)
Bilirubin < 1.5 times ULN (or < 2 mg/dL)
AST and/or ALT < 3 times ULN (< 5 times ULN with liver metastases)
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
No concurrent malignancy requiring therapy except minor surgery for non-melanoma skin cancer removal
No interstitial lung disease with symptoms (e.g., dyspnea or cough) including any of the following significant conditions:
Parenchymal lung disease
Metastatic disease
Pulmonary infections
PRIOR CONCURRENT THERAPY:
See Disease Characteristics
No prior EGFR inhibitors, irinotecan hydrochloride, or other second-line chemotherapy regimens
More than 4 weeks since prior radiotherapy
No other concurrent investigational agents
No other concurrent anticancer treatment modalities (e.g., radiotherapy)
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There are 9 Locations for this study
Arlington Heights Illinois, 60005, United States
Chicago Illinois, 60611, United States
Chicago Illinois, 60611, United States
Joliet Illinois, 60435, United States
Terre Haute Indiana, 47802, United States
Wichita Kansas, 67214, United States
Omaha Nebraska, 68114, United States
Mount Holly New Jersey, 08060, United States
Oklahoma City Oklahoma, 73120, United States
Germantown Tennessee, 38138, United States
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