Exercise and Colon Cancer

Inclusion Criteria:

histologically confirmed TNM stage II-III CC;
completed surgical resection and adjuvant chemotherapy (if applicable) within 1-24 months before entering the study;
≤120 min/wk of self-reported moderate or vigorous intensity physical activity using the Paffenbarger physical activity questionnaire;
age ≥18 years;
written physician approval;
no additional surgery planned within the 6-month intervention (including colostomy reversal);
ability to walk unaided for 6-minutes;
no contraindications to exercise using the PA readiness questionnaire (PAR-Q), unless physician approves participation with specific knowledge of this contraindication.

Exclusion Criteria:

history of another primary invasive cancer (other than non-melanoma skin-cancer);
evidence of metastatic CC (i.e., TNM M1);
planning to receive any additional adjuvant chemotherapy;
pregnant or breast feeding;
unable to provide baseline blood sample;

cardiac conditions, including the following:

myocardial infarction or coronary revascularization procedure within prior 3 months;
uncontrolled hypertension (systolic ≥180 mmHg or diastolic ≥100 mmHg);
high-risk or uncontrolled arrhythmias;
clinically significant valvular disease;
decompensated heart failure;
known aortic aneurysm;
any other condition that may impede testing of the study hypothesis or make it unsafe to engage in the exercise program (determined by the investigative team).