Colon Cancer Clinical Trial
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
Summary
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
View Full Description
Full Description
This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation
Unresectable or metastatic disease
Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts
Adequate organ function
Exclusion Criteria:
History of intestinal disease or major gastric surgery or inability to swallow oral medications
Other active cancer
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There are 95 Locations for this study
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University of Alabama at Birmingham
Birmingham Alabama, 35294, United States
Birmingham Alabama, 35294, United States
Alaska Oncology and Hematology
Anchorage Alaska, 99508, United States
Anchorage Alaska, 99508, United States
Mayo Clinic in Arizona
Phoenix Arizona, 85054, United States
Phoenix Arizona, 85054, United States
Arizona Oncology Associates
Tucson Arizona, 85704, United States
Tucson Arizona, 85704, United States
Kaiser Permanente-Bellflower Medical Offices
Bellflower California, 90706, United States
Bellflower California, 90706, United States
Beverly Hills Cancer Center
Beverly Hills California, 90211, United States
Beverly Hills California, 90211, United States
City of Hope
Duarte California, 91010, United States
Duarte California, 91010, United States
St. Joseph Heritage Healthcare
Fullerton California, 92835, United States
Fullerton California, 92835, United States
University of California San Diego Moores Cancer Center
La Jolla California, 92093, United States
La Jolla California, 92093, United States
Cancer & Blood Specialty Clinic
Los Alamitos California, 90720, United States
Los Alamitos California, 90720, United States
Valkyrie Clinical Trials
Los Angeles California, 90067, United States
Los Angeles California, 90067, United States
Hoag Memorial Hospital Presbyterian
Newport Beach California, 92663, United States
Newport Beach California, 92663, United States
University of California, Irvine
Orange California, 92868, United States
Orange California, 92868, United States
California Cancer Associates for Research and Excellence
San Diego California, 92111, United States
San Diego California, 92111, United States
Ridley - Tree Cancer Center - Santa Barbara
Santa Barbara California, 93105, United States
Santa Barbara California, 93105, United States
Kaiser Permanente
Vallejo California, 94589, United States
Vallejo California, 94589, United States
Rocky Mountain Cancer Centers
Aurora Colorado, 80012, United States
Aurora Colorado, 80012, United States
University of Colorado Hospital
Aurora Colorado, 80045, United States
Aurora Colorado, 80045, United States
SCL Health - Saint Joseph Hospital Cancer Center
Denver Colorado, 80218, United States
Denver Colorado, 80218, United States
St. Mary's Hospital & Regional Medical Center - Research
Grand Junction Colorado, 81501, United States
Grand Junction Colorado, 81501, United States
Yale Cancer Center
New Haven Connecticut, 06511, United States
New Haven Connecticut, 06511, United States
Medical Oncology Hematology Consultants
Newark Delaware, 19713, United States
Newark Delaware, 19713, United States
SCRI - Florida Cancer Specialists- South
Fort Myers Florida, 33901, United States
Fort Myers Florida, 33901, United States
Mayo Clinic in Florida
Jacksonville Florida, 32224, United States
Jacksonville Florida, 32224, United States
Mount Sinai Comprehensive Cancer Center
Miami Beach Florida, 33140, United States
Miami Beach Florida, 33140, United States
Miami Cancer Institute Baptist Health
Miami Florida, 33176, United States
Miami Florida, 33176, United States
Florida Cancer Affiliates - Ocala
Ocala Florida, 34471, United States
Ocala Florida, 34471, United States
Mid Florida Hematology and Oncology Center
Orange City Florida, 37263, United States
Orange City Florida, 37263, United States
Woodlands Medical Specialists
Pensacola Florida, 32503, United States
Pensacola Florida, 32503, United States
BRCR Medical Center
Plantation Florida, 33322, United States
Plantation Florida, 33322, United States
SCRI - Florida Cancer Specialists-North
Saint Petersburg Florida, 33705, United States
Saint Petersburg Florida, 33705, United States
SCRI - Florida Cancer Specialists- East
West Palm Beach Florida, 33401, United States
West Palm Beach Florida, 33401, United States
University Cancer and Blood Center
Athens Georgia, 30607, United States
Athens Georgia, 30607, United States
Northwest Georgia Oncology Centers, PC
Marietta Georgia, 30060, United States
Marietta Georgia, 30060, United States
Affiliated Oncologists - Millenium Medical Center
Chicago Ridge Illinois, 60415, United States
Chicago Ridge Illinois, 60415, United States
Illinois Cancer Specialists - Niles
Niles Illinois, 60714, United States
Niles Illinois, 60714, United States
University of Iowa Hospital & Clinics
Iowa City Iowa, 52242, United States
Iowa City Iowa, 52242, United States
University of Kansas Medical Center
Westwood Kansas, 66205, United States
Westwood Kansas, 66205, United States
University of Kentucky
Lexington Kentucky, 40536, United States
Lexington Kentucky, 40536, United States
SCRI - Hematology Oncology Clinic
Baton Rouge Louisiana, 70809, United States
Baton Rouge Louisiana, 70809, United States
Main Health Cancer Center Biddeford
Biddeford Maine, 04005, United States
Biddeford Maine, 04005, United States
Maryland Oncology Hematology-Columbia
Columbia Maryland, 21044, United States
Columbia Maryland, 21044, United States
Massachusetts General Hospital
Boston Massachusetts, 02114, United States
Boston Massachusetts, 02114, United States
Dana Farber Cancer Institute
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
Barbara Ann Karmanos Cancer Institute
Detroit Michigan, 48201, United States
Detroit Michigan, 48201, United States
Henry Ford Medical Center
Detroit Michigan, 48377, United States
Detroit Michigan, 48377, United States
Minnesota Oncology
Minneapolis Minnesota, 55102, United States
Minneapolis Minnesota, 55102, United States
University of Minnesota
Minneapolis Minnesota, 55454, United States
Minneapolis Minnesota, 55454, United States
Mayo Clinic in Minnesota
Rochester Minnesota, 55905, United States
Rochester Minnesota, 55905, United States
Metro-Minnesota Community Oncology Research Consortium
Saint Louis Park Minnesota, 55416, United States
Saint Louis Park Minnesota, 55416, United States
Central Care Cancer Center - Bolivar
Bolivar Missouri, 65613, United States
Bolivar Missouri, 65613, United States
Goldschmidt Cancer Center- Central Region Medical Center
Jefferson City Missouri, 65109, United States
Jefferson City Missouri, 65109, United States
Frontier Cancer Center
Billings Montana, 59102, United States
Billings Montana, 59102, United States
Nebraska Cancer Specialists
Omaha Nebraska, 68130, United States
Omaha Nebraska, 68130, United States
University of Nebraska Medical Center
Omaha Nebraska, 68198, United States
Omaha Nebraska, 68198, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89169, United States
Las Vegas Nevada, 89169, United States
New York Oncology Hematology - Albany Medical Center
Albany New York, 12206, United States
Albany New York, 12206, United States
Roswell Park
Buffalo New York, 14263, United States
Buffalo New York, 14263, United States
Perlmutter Cancer Center
New York New York, 10016, United States
New York New York, 10016, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
New York New York, 10065, United States
University of North Carolina
Chapel Hill North Carolina, 27514, United States
Chapel Hill North Carolina, 27514, United States
FirstHealth Outpatient Cancer Center
Pinehurst North Carolina, 28374, United States
Pinehurst North Carolina, 28374, United States
The Christ Hospital Cancer Center
Cincinnati Ohio, 45219, United States
Cincinnati Ohio, 45219, United States
University of Cincinnati Health Barrett Cancer Center
Cincinnati Ohio, 45219, United States
Cincinnati Ohio, 45219, United States
Cleveland Clinic
Cleveland Ohio, 44195, United States
Cleveland Ohio, 44195, United States
OSU Medical Center
Columbus Ohio, 43210, United States
Columbus Ohio, 43210, United States
SCRI - Mark H. Zangmeister Cancer Center
Columbus Ohio, 43219, United States
Columbus Ohio, 43219, United States
Kettering Cancer Center
Kettering Ohio, 45429, United States
Kettering Ohio, 45429, United States
Cancer Centers of Southwest Oklahoma - Leah M. Fitch Cancer Center
Lawton Oklahoma, 73505, United States
Lawton Oklahoma, 73505, United States
St. Charles Health System
Bend Oregon, 97701, United States
Bend Oregon, 97701, United States
Willamette Valley Cancer Institute and Research Center - Eugene
Eugene Oregon, 97401, United States
Eugene Oregon, 97401, United States
Lehigh Valley Heath
Allentown Pennsylvania, 18103, United States
Allentown Pennsylvania, 18103, United States
Penn State Health Milton S. Hershey Medical Center
Hershey Pennsylvania, 17033, United States
Hershey Pennsylvania, 17033, United States
Charleston Oncology P.A.
Charleston South Carolina, 29414, United States
Charleston South Carolina, 29414, United States
Medical University of South Carolina
Charleston South Carolina, 29425, United States
Charleston South Carolina, 29425, United States
Tennessee Oncology/The Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States
Nashville Tennessee, 37203, United States
Texas Oncology-Arlington
Arlington Texas, 76014, United States
Arlington Texas, 76014, United States
USOR - Texas Oncology - Austin Central
Austin Texas, 78731, United States
Austin Texas, 78731, United States
Mary Crowley Cancer Research
Dallas Texas, 75231, United States
Dallas Texas, 75231, United States
Texas Oncology at Presbyterian Dallas
Dallas Texas, 75231, United States
Dallas Texas, 75231, United States
USOR Texas Oncology Baylor Charles A. Sammons Cancer Center
Dallas Texas, 75246, United States
Dallas Texas, 75246, United States
Texas Oncology
Fort Worth Texas, 76104, United States
Fort Worth Texas, 76104, United States
Oncology Consultants - Texas Medical Center
Houston Texas, 77030, United States
Houston Texas, 77030, United States
The University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States
Houston Texas, 77030, United States
Lumi Research
Kingwood Texas, 77339, United States
Kingwood Texas, 77339, United States
Texas Oncology Midland
Midland Texas, 79701, United States
Midland Texas, 79701, United States
South Texas Accelerated Research Therapeutics
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Texas Oncology
Sugar Land Texas, 77479, United States
Sugar Land Texas, 77479, United States
Texas Oncology
Tyler Texas, 75702, United States
Tyler Texas, 75702, United States
Texas Oncology Waco
Waco Texas, 76712, United States
Waco Texas, 76712, United States
Virginia Cancer Specialists
Fairfax Virginia, 22031, United States
Fairfax Virginia, 22031, United States
Hematology Oncology Associates of Fredericksburg
Fredericksburg Virginia, 22408, United States
Fredericksburg Virginia, 22408, United States
Virginia Oncology Associates-Newport News
Newport News Virginia, 23606, United States
Newport News Virginia, 23606, United States
Virginia Cancer Institute
Richmond Virginia, 23230, United States
Richmond Virginia, 23230, United States
Seattle Cancer Care Alliance
Seattle Washington, 98109, United States
Seattle Washington, 98109, United States
USOR - Compass Oncology - Vancouver
Vancouver Washington, 98684, United States
Vancouver Washington, 98684, United States
University of Wisconsin Carbone Cancer Center
Madison Wisconsin, 53792, United States
Madison Wisconsin, 53792, United States
PanOncology Trials
San Juan , 00935, Puerto Rico
San Juan , 00935, Puerto Rico
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