Esophageal Cancer Clinical Trial

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A Study of ERY974 in Patient With Advanced Solid Tumors

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Summary

This is the open label, multicenter Phase 1 study which consists of a dose escalation to determine the maximum tolerated dose (MTD) and cohort expansion to obtain a preliminary evaluation of anti-tumor activity. ERY974 is intravenously injected to patients with Glypican 3 positive advanced solid tumors until unacceptable toxicity or disease progression.

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Eligibility Criteria

Inclusion Criteria:

Male or female patient with Glypican 3 positive advanced solid tumor not amenable to standard therapy or for which standard therapy is not available or not indicated
Measurable tumor
Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1
Adequate bone marrow, liver, and renal function
Adequate coagulation status

Exclusion Criteria:

Patients with more than a single brain metastasis ( >1 cm)
Patients with acute or chronic infection
Major surgery within 28 days
Pregnant or lactating women
Patients with interstitial pneumonitis
Patients require regular ascites/pleural effusion drainage

Study is for people with:

Esophageal Cancer

Phase:

Phase 1

Estimated Enrollment:

29

Study ID:

NCT02748837

Recruitment Status:

Completed

Sponsor:

Chugai Pharmaceutical

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There is 1 Location for this study

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Washington District of Columbia, , United States

Tampa Florida, , United States

Boston Massachusetts, , United States

Detroit Michigan, , United States

New York New York, , United States

Durham North Carolina, , United States

Providence Rhode Island, , United States

Paris , , France

Villejuif , , France

Groningen , , Netherlands

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 1

Estimated Enrollment:

29

Study ID:

NCT02748837

Recruitment Status:

Completed

Sponsor:


Chugai Pharmaceutical

How clear is this clinincal trial information?

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