Esophageal Cancer Clinical Trial

Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression

Summary

The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6) to placebo plus mFOLFOX6 as assessed by overall survival (OS).

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Adults with histologically documented unresectable, locally advanced or metastatic gastric or gastroesophageal junction cancer not amenable to curative therapy
Fibroblast growth factor receptor 2b (FGFR2b) ≥10% 2+/3+ tumor cell staining as determined by centrally performed immunohistochemistry (IHC) testing, based on tumor sample either archival (obtained within 6 months/180 days prior to signing pre-screening informed consent) or a fresh biopsy
Eastern Cooperative Oncology Group (ECOG) less than or equal to 1
Measurable disease or non-measurable, but evaluable disease, according to Response Evaluation Criteria in Solid Tumors (RECIST) V 1.1
Participant has no contraindications to mFOLFOX6 chemotherapy

Adequate organ and bone marrow function:

absolute neutrophil count greater than or equal to 1.5 times 10^9/L
platelet count greater than or equal to 100 times 10^9/L
hemoglobin ≥ 9 g/dL without red blood cell (RBC) transfusion within 7 days prior to the first dose of study treatment
aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 3 times the upper limit of normal (ULN) (or less than 5 times ULN if liver involvement). Total bilirubin less than 1.5 times ULN (or less than 2 times ULN if liver involvement); with the exception of participants with Gilbert's disease)
calculated or measured creatinine clearance (CrCl) of ≥ 30 mL/minute calculated using the formula of Cockcroft and Gault ([140 - Age]) × Mass [kg]/[72 × Creatinine mg/dL]) (x 0.85 if female)
international normalized ratio (INR) or prothrombin time (PT) less than 1.5 times ULN except for participants receiving anticoagulation, who must be on a stable dose of anticoagulant therapy for 6 weeks prior to enrollment

Exclusion Criteria:

Prior treatment for metastatic or unresectable disease (Note: prior adjuvant, neo-adjuvant, and peri-operative therapy is allowed if completed more than 6 months prior to first dose of study treatment)
Prior treatment with any selective inhibitor of fibroblast growth factor - fibroblast growth factor receptor (FGF-FGFR) pathway
Known human epidermal growth factor receptor 2 (HER2) positive
Untreated or symptomatic central nervous system (CNS) disease or brain metastases
Peripheral sensory neuropathy greater than or equal to Grade 2
Clinically significant cardiac disease
Other malignancy within the last 2 years (exceptions for definitively treated disease)
Chronic or systemic ophthalmological disorders
Major surgery or other investigational study within 28 days prior to first dose of study treatment
Palliative radiotherapy within 14 days prior to the first dose of study treatment
Evidence of or recent history (within 6 months) of corneal defects, corneal ulcerations, keratitis, or keratoconus, history of corneal transplant, or other known abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer.

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

516

Study ID:

NCT05052801

Recruitment Status:

Recruiting

Sponsor:

Amgen

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There are 285 Locations for this study

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Alaska Oncology and Hematology
Anchorage Alaska, 99508, United States
Mayo Clinic Arizona
Phoenix Arizona, 85054, United States
The Oncology Institute Clinical Research
Cerritos California, 90703, United States
University of California Los Angeles
Los Angeles California, 90095, United States
Mayo Clinic Florida
Jacksonville Florida, 32224, United States
Saint Francis Medical Group
Indianapolis Indiana, 46237, United States
University of Michigan
Ann Arbor Michigan, 48109, United States
Mayo Clinic Rochester
Rochester Minnesota, 55905, United States
Healthier Hematology and Oncology Excelsior Integrated Medical Group
Brooklyn New York, 11220, United States
White Plains Hospital Medical Center
White Plains New York, 10604, United States
Levine Cancer Institute University
Charlotte North Carolina, 28204, United States
FirstHealth Cancer Center
Pinehurst North Carolina, 28374, United States
Avera Cancer Institute
Sioux Falls South Dakota, 57108, United States
Vanderbilt University Medical Center
Nashville Tennessee, 37232, United States
Inova Schar Cancer Institute
Fairfax Virginia, 22031, United States
Medical Oncology Associates, PS
Spokane Washington, 99208, United States
Instituto Alexander Fleming
Caba Buenos Aires, C1426, Argentina
Hospital Universitario Fundacion Favaloro
Ciudad Autonoma de Buenos Aires Buenos Aires, C1093, Argentina
Sociedad de Beneficencia Hospital Italiano
Cordoba Córdoba, 5000, Argentina
Hospital Privado Universitario de Cordoba
Cordoba Córdoba, X5016, Argentina
Hospital Provincial del Centenario
Rosario Santa Fe, S2002, Argentina
Exelsus Oncologia Clinica
San Miguel de Tucuman Tucuman, 4000, Argentina
Instituto Argentino de Diagnostico y Tratamiento IADT
Buenos Aires , C1122, Argentina
Hospital Britanico de Buenos Aires
Buenos Aires , C1280, Argentina
Liverpool Hospital
Liverpool New South Wales, 2170, Australia
St John of God Murdoch Hospital
Murdoch Western Australia, 6150, Australia
Universitair Ziekenhuis Antwerpen
Edegem , 2650, Belgium
Universitair Ziekenhuis Gent
Gent , 9000, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven , 3000, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liege , 4000, Belgium
Núcleo de Oncologia da Bahia
Salvador Bahia, 40170, Brazil
Centro de Oncologia Mackenzie
Curitiba Paraná, 80440, Brazil
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda
Ijui Rio Grande Do Sul, 98700, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
Porto Alegre Rio Grande Do Sul, 90610, Brazil
Clinica de Oncologia Reichow
Blumenau Santa Catarina, 89010, Brazil
Centro de Pesquisa e Ensino em Oncologia de Santa Catarina
Florianopolis Santa Catarina, 88020, Brazil
Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas
Santo Andre São Paulo, 09060, Brazil
Instituto Nacional de Cancer
Rio de Janeiro , 20231, Brazil
Hospital Nove de Julho - dasa
São Paulo , 01409, Brazil
Instituto Brasileiro de Controle do Cancer Ibcc
São Paulo , 04014, Brazil
Multiprofile Hospital for Active Treatment Park Hospital EOOD
Branipole Village , 4109, Bulgaria
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD
Haskovo , 6300, Bulgaria
University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD
Pleven , 5800, Bulgaria
University Multiprofile Hospital for Active Treatment Pulmed OOD
Plovdiv , 4002, Bulgaria
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
Sofia , 1407, Bulgaria
Multiprofile Hospital for Active Treatment Serdika EOOD
Sofia , 1632, Bulgaria
Cross Cancer Institute
Edmonton Alberta, T6G 1, Canada
The Ottawa Hospital Cancer Centre
Ottawa Ontario, K1H 8, Canada
Sunnybrook Research Institute Sunnybrook Health Sciences Centre
Toronto Ontario, M4N 3, Canada
Jewish General Hospital
Montreal Quebec, H3T 1, Canada
James Lind Centro de Investigacion del Cancer
Temuco Cautín, 48008, Chile
Clinica CIDO
Temuco Cautín, 48102, Chile
Centro de Estudios Clinicos SAGA Spa
Santiago , 75006, Chile
Centro de Estudios Clinicos e Investigaciones Medicas CeCim
Santiago , 83200, Chile
The First Affiliated Hospital of Bengbu Medical College
Bengbu Anhui, 23309, China
The First Affiliated Hospital of Anhui Medical University
Hefei Anhui, 23002, China
Anhui Provincial Cancer Hospital
Hefei Anhui, 23003, China
Cancer Hospital of Chinese Academy of Medical Sciences
Beijing Beijing, 10002, China
Huntington Medical Education Foundation
Beijing Beijing, 10003, China
Chongqing University Three Gorges Hospital
Chongqing Chongqing, 40003, China
Fujian Medical University Union Hospital
Fuzhou Fujian, 35000, China
Fujian Cancer Hospital
Fuzhou Fujian, 35001, China
The First Affiliated Hospital of Xiamen University
Xiamen Fujian, 36100, China
Lanzhou University Second Hospital
Lanzhou Gansu, 73003, China
Gansu Wuwei Tumour Hospital
Wuwei Gansu, 73300, China
Sun Yat-sen University Cancer Center
Guangzhou Guangdong, 51003, China
Guangdong Provincial Peoples Hospital
Guangzhou Guangdong, 51018, China
Sun Yat-sen University Cancer Center
Guangzhou Guangdong, 51070, China
Cancer Hospital of Shantou University Medical College
Shantou Guangdong, 51503, China
The First Affiliated Hospital of Hainan Medical University
Haikou Hainan, 57010, China
Fourth Hospital of Hebei Medical University
Shijiazhuang Hebei, 05001, China
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of ScienceandTechnology
Wuhan Hebei, 43003, China
Harbin Medical University Cancer Hospital
Harbin Heilongjiang, 15000, China
Anyang Cancer Hospital
Anyang Henan, 45500, China
The First Affiliated Hospital of Henan University of science and Technology
Luoyang Henan, 47100, China
Henan Cancer Hospital
Zhengzhou Henan, 45000, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou Henan, 45005, China
Taihe Hospital Affiliated Hospital of Hubei University of Medicine
Shiyan Hubei, 44200, China
Hubei Cancer Hospital
Wuhan City Hubei, 43007, China
The Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech
Wuhan Hubei, 43000, China
Xiangya Hospital of Central South University
Changsha Hunan, 41000, China
Hunan Cancer Hospital
Changsha Hunan, 41000, China
Nanjing First Hospital
Nanjing Jiangsu, 21000, China
The Second Affiliated Hospital of Soochow University
Suzhou Jiangsu, 21500, China
Affiliated Hospital of Jiangnan University
Wuxi Jiangsu, 21412, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou Jiangsu, 22100, China
The First Affiliated Hospital of Nanchang University
Nanchang Jiangxi, 33000, China
The First Hospital of Jilin University
Changchun Jilin, 13002, China
China-Japan Union Hospital of Jilin University
Changchun Jilin, 13002, China
The First Affiliated Hospital of Jinzhou Medical University
Jinzhou Liaoning, 12100, China
The First Hospital of China Medical University
Shenyang Liaoning, 11000, China
Liaoning Cancer Hospital
Shenyang Liaoning, 11004, China
The First Affiliated Hospital of Xi an Jiaotong University
XI An Shaanxi, 71006, China
Jinan Central Hospital
Jinan Shandong, 25001, China
The Affiliated Cancer Hospital of Shandong First Medical University
Jinan Shandong, 25011, China
The Affiliated Hospital of Qingdao University
Qingdao Shandong, 26600, China
Fudan University Shanghai Cancer Center
Shanghai Shanghai, 20003, China
Zhongshan Hospital Fudan University
Shanghai Shanghai, 20003, China
Shanghai General Hospital
Shanghai Shanghai, 20008, China
Shanghai East Hospital
Shanghai Shanghai, 20012, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai Shanghai, 20180, China
Changzhi Peoples Hospital
Changzhi Shanxi, 04600, China
Linfen Central Hospital
Linfen Shanxi, 10003, China
Shanxi Province Cancer Hospital
Taiyuan Shanxi, 03001, China
Sichuan Cancer Hospital
Chengdu Sichuan, 61004, China
The First Affiliated Hospital Zhejiang University School of Medicine
Hangzhou Zhejiang, 31000, China
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou Zhejiang, 31000, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou Zhejiang, 31001, China
Taizhou Hospital of Zhejiang Province
Linhai Zhejiang, 31700, China
Lishui Municipal central Hospital
Lishui Zhejiang, 32300, China
The First Affiliate Hospital of Ningbo University
Ningbo Zhejiang, 31501, China
Peoples Hospital of Quzhou
Quzhou Zhejiang, 32400, China
Beijing Cancer Hospital
Beijing , 10014, China
Tianjin Medical University Cancer institute and hospital
Tianjin , 30006, China
Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SA
Rionegro Antioquia, 05404, Colombia
Sociedad de Oncologia y Hematologia del Cesar
Valledupar Cesar, 20000, Colombia
Fundacion Cardiovascular de Colombia
Bucaramanga Santander, 68101, Colombia
Instituto Cancerologico de Narino Ltda
Pasto , 52000, Colombia
Masarykuv onkologicky ustav
Brno , 656 5, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Kralove , 500 0, Czechia
Fakultni nemocnice Olomouc
Olomouc , 779 0, Czechia
Vseobecna fakultni nemocnice v Praze
Praha 2 , 128 0, Czechia
Fakultni Thomayerova nemocnice
Praha 4 , 140 5, Czechia
Rigshospitalet
Copenhagen , 2100, Denmark
North Estonia Medical Centre Foundation
Tallinn , 13419, Estonia
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud
Amiens Cedex 1 , 80054, France
Sainte Catherine - Institut du Cancer d Avignon
Avignon cedex 9 , 84918, France
Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz
Besançon , 25030, France
Centre Hospitalier Universitaire de Brest - Cavale Blanche
Brest , 29200, France
Centre Hospitalier Universitaire de Clermont Ferrand, Hôpital Estaing
Clermont-Ferrand cedex 1 , 63003, France
Centre Hospitalier Régional Universitaire de Lille - Hôpital Claude Huriez
Lille , 59037, France
Centre Leon Berard
Lyon cedex 8 , 69373, France
Institut Mutualiste Montsouris
Paris Cedex 14 , 75674, France
Hôpital Européen Georges Pompidou
Paris , 75015, France
Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré
Reims Cedex , 51092, France
Centre Hospitalier Universitaire Nord de Saint Etienne - Hôpital Nord
Saint Priest en Jarez , 42270, France
Institut de cancerologie Strasbourg Europe
Strasbourg cedex , 67065, France
Institut Gustave Roussy
Villejuif , 94805, France
Agios Savvas Anticancer Hospital
Athens , 11522, Greece
251 General Airforce Hospital
Athens , 11525, Greece
General Hospital of Athens Laiko
Athens , 11526, Greece
Evgenidio Hospital I Agia Trias
Athens , 11528, Greece
Metropolitan Hospital
Athens , 18547, Greece
University Hospital of Heraklion
Heraklion - Crete , 71500, Greece
University Hospital of Larissa
Larissa , 41110, Greece
University Hospital of Patras
Patra , 26504, Greece
Anticancer Hospital of Thessaloniki Theageneio
Thessaloniki , 54007, Greece
Bioclinic of Thessaloniki
Thessaloniki , 54622, Greece
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
Gyor , 9024, Hungary
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula , 5700, Hungary
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz
Miskolc , 3526, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
Nyiregyhaza , 4400, Hungary
Tolna Varmegyei Balassa Janos Korhaz
Szekszard , 7100, Hungary
St Vincents University Hospital
Dublin 4 , D04T6, Ireland
St James Hospital
Dublin , 8, Ireland
Assuta Medical Center
Jerusalem , 91031, Israel
Hadassah Ein-Kerem Medical Center
Jerusalem , 91120, Israel
Meir Medical Center
Kfar Saba , 44281, Israel
Istituto Ospedaliero Fondazione Poliambulanza
Brescia , 25124, Italy
Azienda Ospedaliera Rilievo Nazionale e Alta Specializzazione Garibaldi Nesima
Catania , 95122, Italy
Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II
Lecce , 73100, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milano , 20162, Italy
Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula
Monserrato CA , 09042, Italy
Azienda Unita Saniataria Locale IRCCS di Reggio Emilia
Reggio Emilia , 42100, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma , 00168, Italy
Azienda Ospedaliera San Giovanni Addolorata
Roma , 00184, Italy
IRCCS Istituto Clinico Humanitas
Rozzano MI , 20089, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino , 10128, Italy
Azienda Ospedaliera Cardinale Giovanni Panico
Tricase , 73039, Italy
Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della Misericordia
Udine , 33100, Italy
Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo Trento
Verona , 37126, Italy
Aichi Cancer Center
Nagoya-shi Aichi, 464-8, Japan
Nagoya University Hospital
Nagoya-shi Aichi, 466-8, Japan
Chiba Cancer Center
Chiba-shi Chiba, 260-8, Japan
National Cancer Center Hospital East
Kashiwa-shi Chiba, 277-8, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama-shi Ehime, 791-0, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka-shi Fukuoka, 811-1, Japan
Gifu University Hospital
Gifu-shi Gifu, 501-1, Japan
Hokkaido University Hospital
Sapporo Hokkaido, 060-8, Japan
Hyogo Cancer Center
Akashi-shi Hyogo, 673-8, Japan
Kobe City Medical Center General Hospital
Kobe-shi Hyogo, 650-0, Japan
Ishikawa Prefectural Central Hospital
Kanazawa-shi Ishikawa, 920-8, Japan
Kagawa University Hospital
Kita-gun Kagawa, 761-0, Japan
Yokohama City University Medical Center
Yokohama-shi Kanagawa, 232-0, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
Yokohama-shi Kanagawa, 241-8, Japan
Kyoto University Hospital
Kyoto-shi Kyoto, 606-8, Japan
Niigata Cancer Center Hospital
Niigata-shi Niigata, 951-8, Japan
Kansai Medical University Hospital
Hirakata-shi Osaka, 573-1, Japan
Osaka International Cancer Institute
Osaka-shi Osaka, 541-8, Japan
Kindai University Hospital
Osakasayama-shi Osaka, 589-8, Japan
Osaka University Hospital
Suita-shi Osaka, 565-0, Japan
Saitama Cancer Center
Kitaadachi-gun Saitama, 362-0, Japan
Shizuoka Cancer Center
Sunto-gun Shizuoka, 411-8, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku Tokyo, 135-8, Japan
Keio University Hospital
Shinjuku-ku Tokyo, 160-8, Japan
Dong-A University Hospital
Busan , 49201, Korea, Republic of
Kyungpook National University Chilgok Hospital
Daegu , 41404, Korea, Republic of
Chungnam National University Hospital
Daejeon , 35015, Korea, Republic of
National Cancer Center
Goyang-si Gyeonggi-do , 10408, Korea, Republic of
The Catholic University of Korea Incheon St Marys Hospital
Incheon , 21431, Korea, Republic of
Jeonbuk National University Hospital
Jeonju-si, Jeollabuk-do , 54907, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do , 13620, Korea, Republic of
Korea University Anam Hospital
Seoul , 02841, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Kangbuk Samsung Hospital
Seoul , 03181, Korea, Republic of
Severance Hospital Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
Seoul , 06591, Korea, Republic of
Korea University Guro Hospital
Seoul , 08308, Korea, Republic of
Pauls Stradins Clinical University Hospital
Riga , 1002, Latvia
Lietuvos sveikatos mokslu universiteto ligonine viesoji istaiga Kauno klinikos
Kaunas , 50161, Lithuania
Viesoji istaiga Klaipedos universitetine ligonine
Klaipeda , 92288, Lithuania
Nacionalinis vezio institutas
Vilnius , 08660, Lithuania
Vilnius University Hospital Santaros Clinic Public Institution
Vilnius , 08661, Lithuania
Sarawak General Hospital
Kuching Sarawak, 93586, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur Wilayah Persekutuan, 50586, Malaysia
University Malaya Medical Centre
Kuala Lumpur Wilayah Persekutuan, 59100, Malaysia
Centro Oncologico Internacional
Tijuana Baja California Norte, 22010, Mexico
Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara Jalisco, 44280, Mexico
Investigacion Biomedica para el Desarrollo de Farmacos SA de CV
Zapopan Jalisco, 45070, Mexico
Christus Muguerza Clinica Vidriera
Monterrey Nuevo León, 64570, Mexico
Filios Alta Medicina sa de cv
Monterrey Nuevo León, 64570, Mexico
Investigación Biomédica para el Desarrollo de Fármacos
Aguascalientes , 20010, Mexico
Trials In Medicine SC
Mexico , 06720, Mexico
Oslo University Hospital
Oslo , 0424, Norway
Centro de Investigacion Clinica Trujillo Eirl
Trujillo La Libertad, 13001, Peru
Centrum Onkologii im prof Franciszka Lukaszczyka
Bydgoszcz , 85-79, Poland
Szpitale Pomorskie Spzoo
Gdynia , 81-51, Poland
Biokinetica SA
Jozefow , 05-41, Poland
Szpital Wojewodzki imienia Mikolaja Kopernika w Koszalinie
Koszalin , 75-58, Poland
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji
Olsztyn , 10-22, Poland
SPZOZ Opolskie Centrum Onkologii imienia prof Tadeusza Koszarowskiego w Opolu
Opole , 45-06, Poland
Wielkopolskie Centrum Onkologii imienia Marii Sklodowskiej-Curie
Poznan , 61-86, Poland
Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
Przemysl , 37-70, Poland
Kliniki Neuroradiochirurgii Spzoo Radom Centr Onkolo im Bohater Radomsk Czerwca -76 Szpital Specjal
Radom , 26-60, Poland
Centro Hospitalar e Universitario de Coimbra EPE
Coimbra , 3004-, Portugal
Hospital da Senhora da Oliveira Guimaraes, EPE
Guimaraes , 4835-, Portugal
Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria
Lisboa , 1649-, Portugal
Centro Hospitalar Universitario do Porto, EPE - Hospital de Santo Antonio
Porto , 4099-, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
Porto , 4200-, Portugal
Centro Hospitalar Universitario de Sao Joao, EPE - Hospital Sao Joao
Porto , 4200-, Portugal
Centro Hospitalar de Entre o Douro e Vouga, EPE - Hospital Sao Sebastiao
Santa Maria da Feira , 4520-, Portugal
Spitalul Judeţean de Urgenţă Dr Constantin Opriş Baia Mare
Baia Mare , 43003, Romania
Institutul Clinic Fundeni
Bucharest , 02232, Romania
Institutul Oncologic Prof Dr Alexandru Trestioreanu Bucuresti
Bucuresti , 02233, Romania
SC Medisprof SRL
Cluj-Napoca , 40005, Romania
Institutul Regional de Oncologie Iasi
Iasi , 70048, Romania
Ovidius Clinical Hospital
Ovidiu , 90590, Romania
National Cancer Centre Singapore
Singapore , 16858, Singapore
The Oncology Centre
Durban , 4001, South Africa
Sandton Oncology Centre
Gauteng , 2021, South Africa
Netcare Milpark Hospital
Johannesburg , 2196, South Africa
Hospital Universitario Reina Sofia
Cordoba Andalucía, 14004, Spain
Hospital Regional Universitario de Malaga
Malaga Andalucía, 29010, Spain
Hospital Universitario Miguel Servet
Zaragoza Aragón, 50009, Spain
Hospital Universitario de Burgos
Burgos Castilla León, 09006, Spain
Hospital Clinic i Provincial de Barcelona
Barcelona Cataluña, 08036, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona Cataluña, 08041, Spain
Corporacio Sanitaria Parc Tauli
Sabadell Cataluña, 08208, Spain
Hospital Universitari i Politecnic La Fe
Valencia Comunidad Valenciana, 46026, Spain
Complexo Hospitalario Universitario de Ourense
Ourense Galicia, 32005, Spain
Hospital Donostia
San Sebastian País Vasco, 20014, Spain
Hospital General Universitario Gregorio Marañon
Madrid , 28009, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Madrid , 28220, Spain
Hospital General Universitario Jose Maria Morales Meseguer
Murcia , 30008, Spain
Sahlgrenska Universitetssjukhuset
Göteborg , 413 4, Sweden
Karolinska Universitetssjukhuset Huddinge
Stockholm , 141 8, Sweden
Norrlands Universitetssjukhus
Umea , 901 8, Sweden
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung , 80756, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung , 83301, Taiwan
China Medical University Hospital
Taichung , 40447, Taiwan
National Cheng Kung University Hospital
Tainan , 70403, Taiwan
Tri-Service General Hospital
Taipei , 11490, Taiwan
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation
Taoyuan , 33305, Taiwan
King Chulalongkorn Memorial Hospital
Bangkok , 10330, Thailand
Rajavithi Hospital
Bangkok , 10400, Thailand
Ramathibodi Hospital
Bangkok , 10400, Thailand
Siriraj Hospital
Bangkok , 10700, Thailand
Baskent Universitesi Adana Doktor Turgut Noyan Uygulama ve Arastirma Merkezi
Adana , 01250, Turkey
Doktor Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi
Ankara , 06100, Turkey
Hacettepe Universitesi Tip Fakultesi Hastanesi
Ankara , 06230, Turkey
Memorial Ankara Hastanesi
Ankara , 06520, Turkey
Ankara Bilkent Sehir Hastanesi
Ankara , 06800, Turkey
Antalya Egitim ve Arastirma Hastanesi
Antalya , 07100, Turkey
Dicle Universitesi Tip Fakultesi
Diyarbakir , 21080, Turkey
Bezmialem Vakif Universitesi Hastanesi
Istanbul , 34093, Turkey
Istanbul Universitesi Cerrahpasa Tip Fakultesi
Istanbul , 34098, Turkey
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
Istanbul , 34722, Turkey
Kartal Dr Lutfi Kirdar Sehir Hastanesi
Istanbul , 34865, Turkey
Izmir Ataturk Egitim ve Arastirma Hastanesi
Izmir , 35150, Turkey
Kocaeli Universitesi Tip Fakultesi Hastanesi
Kocaeli , 41380, Turkey
Inonu Universitesi Turgut Ozal Tip Merkezi
Malatya , 44280, Turkey
Sakarya Egitim ve Arastirma Hastanesi
Sakarya , 54290, Turkey
Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
Samsun , 55200, Turkey
Van Yuzuncu Yil Universitesi Dursun Odabas Tip Merkezi
Van , 65000, Turkey

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

516

Study ID:

NCT05052801

Recruitment Status:

Recruiting

Sponsor:


Amgen

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