Esophageal Cancer Clinical Trial

Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer

Summary

The main purpose of this study is to compare how long patients with gastric or gastroesophageal junction cancer live after receiving nivolumab and ipilimumab or nivolumab and chemotherapy compared with patients receiving chemotherapy alone.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Male or Female at least 18 years of age
Must have gastric cancer or gastroesophageal junction cancer that cannot be operated on and that is advanced or has spread out
Did not receive neoadjuvant or adjuvant treatment (chemotherapy, radiotherapy, or both) for their disease within the last 6 months
Must have full activity or, if limited, must be able to walk and carry out light activities such as light house work or office work
Must agree to provide tumor tissue sample, either from a previous surgery or biopsy within 6 months or fresh, prior to the start of treatment in this study

Exclusion Criteria:

Presence of tumor cells in the brain or spinal cord that have not been treated
Active known or suspected autoimmune disease
Any serious or uncontrolled medical disorder or active infection
Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
Any positive test result for hepatitis B or C indicating acute or chronic infection

Other protocol-defined inclusion/exclusion criteria apply

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

2031

Study ID:

NCT02872116

Recruitment Status:

Active, not recruiting

Sponsor:

Bristol-Myers Squibb

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There are 165 Locations for this study

See Locations Near You

Local Institution - 0005
Los Angeles California, 90033, United States
California Pacific Medical Center Research Institute
San Francisco California, 94115, United States
Local Institution - 0066
Aurora Colorado, 80045, United States
Local Institution - 0151
Denver Colorado, 80218, United States
Local Institution - 0136
Washington District of Columbia, 20007, United States
Florida Cancer Specialists S.
Fort Myers Florida, 33901, United States
Local Institution - 0147
Miami Florida, 33176, United States
Florida Cancer Specialists
Saint Petersburg Florida, 33705, United States
Local Institution - 0179
Marietta Georgia, 30060, United States
Local Institution - 0219
Arlington Heights Illinois, 60005, United States
Local Institution - 0120
Chicago Illinois, 60611, United States
Local Institution - 0021
Baltimore Maryland, 21224, United States
Local Institution - 0002
Boston Massachusetts, 02215, United States
Local Institution - 0135
Boston Massachusetts, 02215, United States
Local Institution - 0003
New York New York, 10065, United States
Local Institution - 0138
Cleveland Ohio, 44106, United States
Local Institution - 0186
Cleveland Ohio, 44195, United States
Local Institution - 0146
Eugene Oregon, 97401, United States
Lehigh Valley Health Network
Allentown Pennsylvania, 18105, United States
Local Institution - 0065
Pittsburgh Pennsylvania, 15224, United States
Local Institution - 0104
Nashville Tennessee, 37203, United States
Local Institution - 0140
Bedford Texas, 76022, United States
Local Institution - 0143
Dallas Texas, 75230, United States
Local Institution - 0213
Dallas Texas, 75246, United States
Local Institution - 0004
Houston Texas, 77030, United States
Texas Oncology-Plano East
Plano Texas, 75075, United States
Local Institution - 0150
Newport News Virginia, 23606, United States
Local Institution - 0030
Caba Buenos Aires, 1426, Argentina
Local Institution - 0028
Capital Federal Buenos Aires, 1264, Argentina
Local Institution - 0029
Capital Federal Buenos Aires, 1280, Argentina
Local Institution - 0183
Viedma RIO Negro, 8500, Argentina
Local Institution - 0026
San Miguel De Tucuman Tucuman, 4000, Argentina
Local Institution - 0027
Cordoba , 5000, Argentina
Local Institution - 0184
La Rioja , 5300, Argentina
Local Institution - 0202
Blacktown New South Wales, 2148, Australia
Local Institution - 0100
Gosford New South Wales, 2250, Australia
Local Institution - 0190
Southport Queensland, 4215, Australia
Local Institution - 0101
Adelaide South Australia, 5000, Australia
Local Institution - 0103
Ballarat Victoria, 3350, Australia
Local Institution - 0102
Shepparton Victoria, 3630, Australia
Local Institution - 0214
St Albans Victoria, 3021, Australia
Local Institution - 0099
Perth Western Australia, 6150, Australia
Local Institution - 0053
Salvador Bahia, 41950, Brazil
Local Institution - 0046
Ijui RIO Grande DO SUL, 98700, Brazil
Local Institution - 0047
Porto Alegre RIO Grande DO SUL, 90035, Brazil
Local Institution - 0048
Barretos Sao Paulo, 14784, Brazil
Local Institution - 0054
Sao Paulo , 01246, Brazil
Local Institution - 0035
Edmonton Alberta, T6G 1, Canada
Local Institution - 0036
London Ontario, N6A 4, Canada
Local Institution - 0067
Toronto Ontario, M5G 2, Canada
Local Institution - 0052
Montreal Quebec, H2X 3, Canada
Local Institution - 0196
Montreal Quebec, H3T 1, Canada
Local Institution - 0051
Quebec City Quebec, G1J 1, Canada
Local Institution - 0068
Sherbrooke Quebec, J1H 5, Canada
Local Institution - 0034
Trois-Rivieres Quebec, G8Z 3, Canada
Local Institution - 0032
Temuco Araucania, 48008, Chile
Local Institution - 0057
Santiago Metropolitana, 83200, Chile
Local Institution - 0031
Santiago Metropolitana, , Chile
Local Institution - 0058
Independencia Santiago, , Chile
Local Institution - 0033
Vina Del Mar Valparaiso, 25403, Chile
Local Institution - 0176
Beijing Beijing, 10000, China
Local Institution - 0178
Beijing Beijing, 10003, China
Local Institution - 0171
Beijing Beijing, 10014, China
Local Institution - 0185
Fuzhou Fujian, 35000, China
Local Institution - 0166
Guangzhou Guangdong, 51006, China
Local Institution - 0160
Harbin Heilongjiang, 15008, China
Local Institution - 0159
Zhengzhou Henan, 45000, China
Local Institution - 0173
Changsha Hunan, 41001, China
Local Institution - 0158
Changzhou Jiangsu, 21300, China
Local Institution - 0187
Nanjing Jiangsu, 21000, China
Local Institution - 0154
Nanjing Jiangsu, 21000, China
Local Institution - 0156
Changchun Jilin, 13001, China
Local Institution - 0155
Changchun Jilin, 13002, China
Local Institution - 0181
Shenyang Liaoning, 11004, China
Local Institution - 0182
Qingdao Shandong, 26606, China
Local Institution - 0165
Shanghai Shanghai, 20003, China
Local Institution - 0175
Shanghai Shanghai, 20003, China
Local Institution - 0167
Urumqi Xinjiang, 83001, China
Local Institution - 0161
Hangzhou Zhejiang, 31000, China
Local Institution - 0168
Hangzhou Zhejiang, 31002, China
Local Institution - 0174
Hangzhou , 31001, China
Local Institution - 0172
Tianjin , 30006, China
Local Institution - 0025
Bogota Cundinamarca, 0, Colombia
Local Institution - 0022
Bogota , 0, Colombia
Local Institution - 0024
Pasto , 0, Colombia
Local Institution - 0200
Brno , 625 0, Czechia
Local Institution - 0197
Brno , 656 5, Czechia
Local Institution - 0080
Caen , 14000, France
Local Institution - 0081
Dijon , 21000, France
Local Institution - 0077
Lille , 59000, France
Local Institution - 0083
Montpellier , 34090, France
Local Institution - 0113
Nantes , 44000, France
Local Institution - 0079
Nice Cedex 2 , 06189, France
Local Institution - 0078
Paris , 75012, France
Local Institution - 0119
Plérin , 22190, France
Local Institution - 0092
Mainz Rheinland-Pfalz, 55131, Germany
Local Institution - 0094
Berlin , 13353, Germany
Local Institution - 0095
Cologne , 50937, Germany
Local Institution - 0089
Dresden , 01307, Germany
Local Institution - 0188
Dusseldorf , 40225, Germany
Local Institution - 0091
Essen , 45122, Germany
Local Institution - 0096
Freiburg , 79106, Germany
Local Institution - 0093
Hamburg , 20251, Germany
Local Institution - 0149
Muenchen , 81675, Germany
Local Institution - 0017
Nea Kifissia Attikí, 14564, Greece
Local Institution - 0056
Athens , 11526, Greece
Local Institution - 0019
Ioannina , 45500, Greece
Local Institution - 0018
Patras , 26504, Greece
Local Institution - 0191
Hong Kong , 0, Hong Kong
Local Institution - 0195
Hong Kong , 0, Hong Kong
Local Institution - 0008
Budapest , 1083, Hungary
Local Institution - 0007
Budapest , 1122, Hungary
Local Institution - 0108
Debrecen , 0, Hungary
Local Institution - 0118
Haifa , 31096, Israel
Local Institution - 0116
Jerusalem , 91120, Israel
Local Institution - 0115
Petach Tikva , 49100, Israel
Local Institution - 0117
Ramat-gan , 52621, Israel
Local Institution - 0114
Tel Aviv , 64239, Israel
Local Institution - 0062
Bergamo , 24127, Italy
Local Institution - 0205
Modena , 41124, Italy
Local Institution - 0061
Napoli , 80131, Italy
Local Institution - 0063
Pisa , 56126, Italy
Local Institution - 0059
Roma , 00168, Italy
Local Institution - 0064
San Giovanni Rotondo , 71013, Italy
Local Institution - 0130
Nagoya Aichi, 46486, Japan
Local Institution - 0128
Chiba-shi Chiba, 260-8, Japan
Local Institution - 0125
Kashiwa Chiba, 277-8, Japan
Local Institution - 0137
Sapporo-shi Hokkaido, 06086, Japan
Local Institution - 0127
Kita-Gun Kagawa, 76107, Japan
Local Institution - 0124
Suita-shi Osaka, 565-0, Japan
Local Institution - 0123
Kitaadachi-gun Saitama, 36208, Japan
Local Institution - 0126
Chuo-ku Tokyo, 10400, Japan
Local Institution - 0122
Minato-ku Tokyo, 10584, Japan
Local Institution - 0129
Tokyo , 13585, Japan
Local Institution - 0132
Seoul , 03722, Korea, Republic of
Local Institution - 0131
Seoul , 05505, Korea, Republic of
Local Institution - 0215
Mexico City Distrito Federal, 03100, Mexico
Local Institution - 0217
Toluca Estado DE Mexico, 50120, Mexico
Local Institution - 0216
Queretaro , 76090, Mexico
Local Institution - 0189
Lima , 27, Peru
Local Institution - 0039
Lima , 34, Peru
Local Institution - 0037
Lima , LIMA , Peru
Local Institution - 0139
Lima , Lima , Peru
Local Institution - 0016
Lublin , 20-08, Poland
Local Institution - 0013
Tarnobrzeg , 39-40, Poland
Local Institution - 0014
Warszawa , 02-03, Poland
Local Institution - 0043
Lisboa , 1649-, Portugal
Local Institution - 0210
Porto , 4200-, Portugal
Local Institution - 0041
Craiova Dolj, 20054, Romania
Local Institution - 0012
Baia Mare Jud Maramures, 43029, Romania
Local Institution - 0040
Bucharest , 02232, Romania
Local Institution - 0042
Cluj-Napoca , 40001, Romania
Local Institution - 0055
Suceava , 72023, Romania
Local Institution - 0071
Chelyabinsk , 45404, Russian Federation
Local Institution - 0086
Moscow , 11547, Russian Federation
Local Institution - 0069
Moscow , 12130, Russian Federation
Local Institution - 0105
Moscow , 12528, Russian Federation
Local Institution - 0085
St. Petersburg , 19825, Russian Federation
Local Institution - 0193
Singapore Central Singapore, 16858, Singapore
Local Institution - 0194
Singapore , 11922, Singapore
Local Institution - 0050
Badajoz , 06006, Spain
Local Institution - 0209
Badalona-barcelona , 08916, Spain
Local Institution - 0044
Barcelona , 08035, Spain
Local Institution - 0049
Pozuelo De Alarcon, Madrid , 28223, Spain
Local Institution - 0045
Valencia , 46010, Spain
Local Institution - 0212
Zaragoza , 50009, Spain
Local Institution - 0148
Tainan , 70403, Taiwan
Local Institution - 0133
Taipei , 11217, Taiwan
Local Institution - 0134
Taoyuan County , 333, Taiwan
Local Institution - 0203
Ankara , 06800, Turkey
Local Institution - 0211
Ankara , 06800, Turkey
Local Institution - 0201
Antalya , 07070, Turkey
Local Institution - 0208
Diyarbakır , 21280, Turkey
Local Institution - 0207
Edrine , 22010, Turkey
Local Institution - 0074
London Greater London, SW3 6, United Kingdom
Local Institution - 0073
Manchester Greater Manchester, M20 4, United Kingdom
Local Institution - 0076
Nottingham Nottinghamshire, NG5 1, United Kingdom
Local Institution - 0075
Sutton Surrey, SM2 5, United Kingdom
Local Institution - 0072
Southampton , SO16 , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

2031

Study ID:

NCT02872116

Recruitment Status:

Active, not recruiting

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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