Esophageal Cancer Clinical Trial
Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer
Summary
The main purpose of this study is to compare how long patients with gastric or gastroesophageal junction cancer live after receiving nivolumab and ipilimumab or nivolumab and chemotherapy compared with patients receiving chemotherapy alone.
Eligibility Criteria
Inclusion Criteria:
Male or Female at least 18 years of age
Must have gastric cancer or gastroesophageal junction cancer that cannot be operated on and that is advanced or has spread out
Did not receive neoadjuvant or adjuvant treatment (chemotherapy, radiotherapy, or both) for their disease within the last 6 months
Must have full activity or, if limited, must be able to walk and carry out light activities such as light house work or office work
Must agree to provide tumor tissue sample, either from a previous surgery or biopsy within 6 months or fresh, prior to the start of treatment in this study
Exclusion Criteria:
Presence of tumor cells in the brain or spinal cord that have not been treated
Active known or suspected autoimmune disease
Any serious or uncontrolled medical disorder or active infection
Known history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS)
Any positive test result for hepatitis B or C indicating acute or chronic infection
Other protocol-defined inclusion/exclusion criteria apply
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There are 165 Locations for this study
Los Angeles California, 90033, United States
San Francisco California, 94115, United States
Aurora Colorado, 80045, United States
Denver Colorado, 80218, United States
Washington District of Columbia, 20007, United States
Fort Myers Florida, 33901, United States
Miami Florida, 33176, United States
Saint Petersburg Florida, 33705, United States
Marietta Georgia, 30060, United States
Arlington Heights Illinois, 60005, United States
Chicago Illinois, 60611, United States
Baltimore Maryland, 21224, United States
Boston Massachusetts, 02215, United States
Boston Massachusetts, 02215, United States
New York New York, 10065, United States
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44195, United States
Eugene Oregon, 97401, United States
Allentown Pennsylvania, 18105, United States
Pittsburgh Pennsylvania, 15224, United States
Nashville Tennessee, 37203, United States
Bedford Texas, 76022, United States
Dallas Texas, 75230, United States
Dallas Texas, 75246, United States
Houston Texas, 77030, United States
Plano Texas, 75075, United States
Newport News Virginia, 23606, United States
Caba Buenos Aires, 1426, Argentina
Capital Federal Buenos Aires, 1264, Argentina
Capital Federal Buenos Aires, 1280, Argentina
Viedma RIO Negro, 8500, Argentina
San Miguel De Tucuman Tucuman, 4000, Argentina
Cordoba , 5000, Argentina
La Rioja , 5300, Argentina
Blacktown New South Wales, 2148, Australia
Gosford New South Wales, 2250, Australia
Southport Queensland, 4215, Australia
Adelaide South Australia, 5000, Australia
Ballarat Victoria, 3350, Australia
Shepparton Victoria, 3630, Australia
St Albans Victoria, 3021, Australia
Perth Western Australia, 6150, Australia
Salvador Bahia, 41950, Brazil
Ijui RIO Grande DO SUL, 98700, Brazil
Porto Alegre RIO Grande DO SUL, 90035, Brazil
Barretos Sao Paulo, 14784, Brazil
Sao Paulo , 01246, Brazil
Edmonton Alberta, T6G 1, Canada
London Ontario, N6A 4, Canada
Toronto Ontario, M5G 2, Canada
Montreal Quebec, H2X 3, Canada
Montreal Quebec, H3T 1, Canada
Quebec City Quebec, G1J 1, Canada
Sherbrooke Quebec, J1H 5, Canada
Trois-Rivieres Quebec, G8Z 3, Canada
Temuco Araucania, 48008, Chile
Santiago Metropolitana, 83200, Chile
Santiago Metropolitana, , Chile
Independencia Santiago, , Chile
Vina Del Mar Valparaiso, 25403, Chile
Beijing Beijing, 10000, China
Beijing Beijing, 10003, China
Beijing Beijing, 10014, China
Fuzhou Fujian, 35000, China
Guangzhou Guangdong, 51006, China
Harbin Heilongjiang, 15008, China
Zhengzhou Henan, 45000, China
Changsha Hunan, 41001, China
Changzhou Jiangsu, 21300, China
Nanjing Jiangsu, 21000, China
Nanjing Jiangsu, 21000, China
Changchun Jilin, 13001, China
Changchun Jilin, 13002, China
Shenyang Liaoning, 11004, China
Qingdao Shandong, 26606, China
Shanghai Shanghai, 20003, China
Shanghai Shanghai, 20003, China
Urumqi Xinjiang, 83001, China
Hangzhou Zhejiang, 31000, China
Hangzhou Zhejiang, 31002, China
Hangzhou , 31001, China
Tianjin , 30006, China
Bogota Cundinamarca, 0, Colombia
Bogota , 0, Colombia
Pasto , 0, Colombia
Brno , 625 0, Czechia
Brno , 656 5, Czechia
Caen , 14000, France
Dijon , 21000, France
Lille , 59000, France
Montpellier , 34090, France
Nantes , 44000, France
Nice Cedex 2 , 06189, France
Paris , 75012, France
Plérin , 22190, France
Berlin , 13353, Germany
Cologne , 50937, Germany
Dresden , 01307, Germany
Dusseldorf , 40225, Germany
Essen , 45122, Germany
Freiburg , 79106, Germany
Hamburg , 20251, Germany
Mainz , 55131, Germany
Muenchen , 81675, Germany
Nea Kifissia AttikÃ, 14564, Greece
Athens , 11526, Greece
Ioannina , 45500, Greece
Patras , 26504, Greece
Hong Kong , 0, Hong Kong
Hong Kong , 0, Hong Kong
Budapest , 1083, Hungary
Budapest , 1122, Hungary
Debrecen , 0, Hungary
Haifa , 31096, Israel
Jerusalem , 91120, Israel
Petach Tikva , 49100, Israel
Ramat-gan , 52621, Israel
Tel Aviv , 64239, Israel
Bergamo , 24127, Italy
Modena , 41124, Italy
Napoli , 80131, Italy
Pisa , 56126, Italy
Roma , 00168, Italy
San Giovanni Rotondo , 71013, Italy
Nagoya Aichi, 46486, Japan
Chiba-shi Chiba, 260-8, Japan
Kashiwa Chiba, 277-8, Japan
Sapporo-shi Hokkaido, 06086, Japan
Kita-Gun Kagawa, 76107, Japan
Suita-shi Osaka, 565-0, Japan
Kitaadachi-gun Saitama, 36208, Japan
Chuo-ku Tokyo, 10400, Japan
Minato-ku Tokyo, 10584, Japan
Tokyo , 13585, Japan
Seoul , 03722, Korea, Republic of
Seoul , 05505, Korea, Republic of
Mexico City Distrito Federal, 03100, Mexico
Toluca Estado DE Mexico, 50120, Mexico
Queretaro , 76090, Mexico
Lima , 27, Peru
Lima , 34, Peru
Lima , LIMA , Peru
Lima , Lima , Peru
Lublin , 20-08, Poland
Tarnobrzeg , 39-40, Poland
Warszawa , 02-03, Poland
Lisboa , 1649-, Portugal
Porto , 4200-, Portugal
Baia Mare Jud Maramures, 43029, Romania
Bucharest , 02232, Romania
Cluj-Napoca , 40001, Romania
Craiova , 20054, Romania
Suceava , 72023, Romania
Chelyabinsk , 45404, Russian Federation
Moscow , 11547, Russian Federation
Moscow , 12130, Russian Federation
Moscow , 12528, Russian Federation
St. Petersburg , 19825, Russian Federation
Singapore , 11922, Singapore
Singapore , 16961, Singapore
Badajoz , 06006, Spain
Badalona-barcelona , 08916, Spain
Barcelona , 08035, Spain
Pozuelo De Alarcon, Madrid , 28223, Spain
Valencia , 46010, Spain
Zaragoza , 50009, Spain
Tainan , 70403, Taiwan
Taipei , 11217, Taiwan
Taoyuan County , 333, Taiwan
Ankara , 06800, Turkey
Ankara , 06800, Turkey
Antalya , 07070, Turkey
Diyarbakır , 21280, Turkey
Edrine , 22010, Turkey
London Greater London, SW3 6, United Kingdom
Manchester Greater Manchester, M20 4, United Kingdom
Nottingham Nottinghamshire, NG5 1, United Kingdom
Sutton Surrey, SM2 5, United Kingdom
Southampton , SO16 , United Kingdom
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