Esophageal Cancer Clinical Trial

Selective Dose Escalation for Esophageal Cancer

Summary

This prospective study was designed to assess the outcomes (survival and failure patterns) of therapy for localized esophageal cancer with conventional dose radiation (RT; 50.4 Gy) with concurrent continuous infusion 5-fluorouracil (5-FU) and weekly carboplatin/paclitaxel. Patients with less than complete response (CR) or partial response (PR) received dose escalation of radiation to 59.4 Gy with the same chemotherapy.

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Full Description

we prospectively enrolled patients with T1-4, N0-1, M0-1a esophageal carcinoma to receive paclitaxel 45 mg/m2 IV over 1 hour and carboplatin AUC 2 IV over 30 minutes on days 1, 8, 15, 22, 29 and 36. 5-FU 225mg/m2 was delivered as a continuous infusion on days 1-38. RT was given 1.8Gy 5 days/wk for 5.5 wks (50.4Gy in 28 fx). After 6-8 weeks, patients underwent repeat staging with computed tomography (CT) scan, endoscopic ultrasound (EUS), and biopsy. Patients with a positive biopsy, or less than PR by CT and EUS, received a boost of 9 Gy with the same concurrent chemotherapy. Patients were followed every 4 months with CT/EUS first year, every 6 months thereafter.

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Eligibility Criteria

Inclusion Criteria:

T1-4, N0-1, M0-1a esophageal carcinoma

Exclusion Criteria:

distant metastases

Study is for people with:

Esophageal Cancer

Phase:

Phase 2

Estimated Enrollment:

25

Study ID:

NCT00139633

Recruitment Status:

Unknown status

Sponsor:

The Oregon Clinic

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There is 1 Location for this study

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The Oregon Clinic
Portland Oregon, 97213, United States

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 2

Estimated Enrollment:

25

Study ID:

NCT00139633

Recruitment Status:

Unknown status

Sponsor:


The Oregon Clinic

How clear is this clinincal trial information?

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