Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus

Inclusion Criteria:

Must have histologically confirmed gastric, gastro-esophageal junction or distal esophageal adenocarcinoma (predominant histology) that is recurrent, metastatic or unresectable
Must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) criteria 1.1
Must have received at least one line but less than three lines of prior systemic therapies and have either progressed or intolerant to prior therapies. Patients who have received adjuvant/neoadjuvant therapy within last one year will be eligible as well.
Eastern Cooperative Oncology Group (ECOG) performance status ≤1
Life expectancy of greater than 3 months
Must have normal organ and marrow function
Women of child-bearing potential (WOCBP) must agree to use dual methods of contraception and have a negative serum pregnancy test at screening. Male participants must use an effective barrier method of contraception if sexually active with a WOCBP. For both male and female participants, effective methods of contraception must be used throughout the study and for three months following the last dose.
Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

Have had chemotherapy, biologic therapy or radiotherapy within 3 weeks prior to entering the study
Are receiving any other investigational agents for anti-cancer treatment within 3 weeks of starting study medication
Symptomatic central nervous system (CNS) metastases
Progression on irinotecan containing regimen
History of allergic reactions attributed to compounds of similar chemical or biologic composition to irinotecan
Major surgery within 2 weeks before cycle 1 Day 1 (C1D1)
Unstable cardiovascular function
Patients who are pregnant or lactating
Uncontrolled infection requiring parenteral antibiotics, antivirals, or antifungals within one week prior to first dose; patients with controlled infection or on prophylactic antibiotics are permitted in the study.
Known active hepatitis A, B, or C infection; or known to be positive for HCV RNA or HBsAg (HBV surface antigen)
Any underlying condition that would significantly interfere with the absorption of an oral medication
> Grade 2 peripheral neuropathy at baseline
Serious psychiatric or medical conditions that could interfere with treatment
Concurrent therapy with approved or investigational anticancer therapeutic other than steroids
History of gastrointestinal perforation and/or fistulae within 6 months prior to C1D1
Use of strong CYP3A4 inducers or inhibitors within 2 weeks of starting study medication