Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease

Inclusion Criteria:

Ability to understand and the willingness to sign a written informed consent document
Patients must be scheduled for a procedure capable of providing a definitive pathologic diagnosis and evaluating for complications of the esophageal sponge on the same day as the study procedure, either upper endoscopy or surgical esophagectomy
One of the following inclusion criteria must be true for patient to be eligible for enrollment:
Subjects with known esophageal cancer (adenocarcinoma or squamous cell carcinoma)
Subjects with a history of low or high grade dysplasia
Subjects with risk factors for esophageal malignancy including Barrett?s esophagus and gastroesophageal reflux disease (GERD)

Exclusion Criteria:

Subjects that are unable to swallow a tablet/pill
Subjects with completely obstructing esophageal cancer
Subjects with known or suspected esophageal varices
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
Any condition which, in the opinion of the investigator precludes the patient from completion of the study procedure