Heart Failure Clinical Trial

Clinical Trial Finder Heart Failure Trials

A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure

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Summary

The aim of this study was to determine whether long-term (≥ 6 months at the target dose) blockade of ETA receptors using sitaxsentan showed functional benefit in subjects with chronic Heart Failure and an Left Ventricular Ejection Fraction ≥50%.

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Eligibility Criteria

Inclusion Criteria:

18 or older with chronic heart failure and evidence of diastolic dysfunction on echocardiogram, heart imaging, and a minimum exercise tolerance average time of 120 seconds on two treadmill tests within 2 weeks of enrollment

Exclusion Criteria:

unstable cardiovascular disease within 4 weeks of screening, history of heart attack, cardiac by-pass surgery or percutaneous intervention, stent placement, within 3 months of screening or amyloidosis, hypertrophic obstructive or restrictive cardiomyopathy, or constrictive pericarditis

Study is for people with:

Heart Failure

Phase:

Phase 2

Estimated Enrollment:

200

Study ID:

NCT00303498

Recruitment Status:

Completed

Sponsor:

Pfizer

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There are 46 Locations for this study

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University of Alabama at Birmingham
Birmingham Alabama, 35294, United States
Mobile Heart Specialists, PC
Mobile Alabama, 36608, United States
Preventative and Research Cardiloogy Providence Hospital
Mobile Alabama, 36608, United States
Central Arkansas Veterans HCS
Little Rock Alaska, 72205, United States
Arizona Pulmonary Specialists, LTD
Phoenix Arizona, 85013, United States
Parkview Research Center
Tucson Arizona, 85715, United States
Southwest Heart
Tucson Arizona, 85715, United States
University of Arkansas for Medical Services/Cardiology Department
Little Rock Arkansas, 72205, United States
University of Southern California Medical Center
Los Angeles California, 90033, United States
Orange County Heart Institute and Research Center
Orange California, 92868, United States
Sacramento Heart & Vascular Medical Associates
Sacramento California, 95825, United States
University of California
San Diego California, 92103, United States
Yale University School of Medicine, Cardiovascular Medicine
New Haven Connecticut, 06510, United States
Capital City Research, CCRW
Washington District of Columbia, 20011, United States
Florida Heart Group Pa
Orlando Florida, 32803, United States
The University of Chicago
Chicago Illinois, 60637, United States
Methodist Medical Center
Peoria Illinois, 61606, United States
Cardiovascular Consultants of Maine
Auburn Maine, 04210, United States
Massachusetts General Hospital Pulmonary and Critical Care Unit
Boston Massachusetts, 02114, United States
Brigham and Women's Hospital
Boston Massachusetts, 02115, United States
VA Med Ctr Minneapolis
Minneapolis Minnesota, 55417, United States
St. Louis University Hospital
Saint Louis Missouri, 63110, United States
Washington Univ. School of Medicine
Saint Louis Missouri, 63110, United States
Nebraska Heart Institute
Lincoln Nebraska, 68526, United States
Catholic Medical Center d/b/a New England Heart Institute
Manchester New Hampshire, 03102, United States
Newark Beth Israel Medical Center
Newark New Jersey, 07112, United States
Buffalo Cardipul Assoc
Buffalo New York, 14221, United States
Columbia University Medical Center, New York Presbyterian Hospital
New York New York, 10032, United States
Capital Cardiology Associates
Troy New York, 11218, United States
Mid Carolina Cardiology
Charlotte North Carolina, 28204, United States
Mid Carolina Cardiology
Huntersville North Carolina, 28078, United States
Wake Forest University Health Sciences
Winston-Salem North Carolina, 27157, United States
The Ohio State University
Columbus Ohio, 43210, United States
Oklahoma Foundation for Cardiovascular Research
Oklahoma City Oklahoma, 73120, United States
The Oregon Clinic
Portland Oregon, 97220, United States
University of Pennsylvania
Philadelphia Pennsylvania, 19104, United States
Advanced Heart Failure & Transplant Center
Philadelphia Pennsylvania, 19140, United States
Albert Einstein Medical Center
Philadelphia Pennsylvania, 19141, United States
Allegheny General Hospital
Pittsburgh Pennsylvania, 15212, United States
RHJ VA Medical Center
Charleston South Carolina, 29401, United States
Black Hills Clinical Research Center
Rapid City South Dakota, 57701, United States
Stern Cardiovascular Center
Germantown Tennessee, 38138, United States
Baylor College of Medicine Pulmonary Section
Houston Texas, 77030, United States
Kelsey Seybold Clinic
Houston Texas, 77030, United States
Methodist DeBakey Heart Center
Houston Texas, 77030, United States
Intermountain Medical Center (a.k.a. LDS Hospital)
Murray Utah, 84157, United States
University of Utah
Salt Lake City Utah, 84132, United States
Fletcher Allen Health Care
Burlington Vermont, 05401, United States
Medical College of Virginia
Richmond Virginia, 23298, United States
University of Wisconsin Hospital & Clinics
Madison Wisconsin, 53792, United States
St Michael's Hospital
Toronto Ontario, M5B1W, Canada
SMBD Jewish General Hospital
Montreal Quebec, H3T 1, Canada
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How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Phase:

Phase 2

Estimated Enrollment:

200

Study ID:

NCT00303498

Recruitment Status:

Completed

Sponsor:


Pfizer

How clear is this clinincal trial information?

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