Heart Failure Clinical Trial
A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction and Obesity
Summary
The main purpose of this study is to assess the efficacy and safety of Tirzepatide (LY3298176) in participants with heart failure with preserved ejection fraction and obesity.
Full Description
The study will continue until approximately 52 weeks after the last participant is randomized. The maximum duration of an individual's participation is estimated to be 120 weeks and will depend on duration of study enrollment.
Eligibility Criteria
Inclusion Criteria:
Have a diagnosis of stable heart failure (NYHA class II-IV) and left ventricular ejection fraction (LVEF) ≥50%
Elevated NT-proBNP (N-terminal pro B-type natriuretic peptide) > 200 pg/ml for participants without atrial fibrillation (AF), or >600 picogram/milliliter (pg/ml) for participants with AF, Structural heart disease (Left atrial enlargement) or Elevated left ventricular filling pressure
Estimated glomerular filtration rate (eGFR) <70 milliliter (ml)/minute (min)/1.73m² at screening, or HF decompensation within 12 months of screening,
Stable dose of heart failure medications within 4 weeks of screening
Body mass index (BMI) ≥30 kilograms per meter squared (kg/m²)
6MWD 100-425m
KCCQ CSS ≤80
Exclusion Criteria:
Have had a major cardiovascular event within the last 90 days of screening
Have had acute decompensated heart failure within 4 weeks of screening
Have non cardiac causes of functional impairment such as pulmonary arterial hypertension (PAH), severe chronic obstructive pulmonary disease (COPD), anemia, thyroid disease, musculoskeletal disease or orthopedic conditions
Presence of cardiac amyloidosis, cardiac accumulation disease, cardiomyopathy and severe valvular hear disease
HbA1c ≥9.5% or uncontrolled diabetes
History of proliferative diabetic retinopathy or diabetic maculopathy
Have a history of pancreatitis
eGFR <15 mL/min/1.73 m² or requiring dialysis at screening
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There are 135 Locations for this study
Huntsville Alabama, 35801, United States More Info
Principal Investigator
Beverly Hills California, 90211, United States More Info
Principal Investigator
Covina California, 91723, United States More Info
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Granada Hills California, 91344, United States More Info
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La Jolla California, 92037, United States More Info
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Northridge California, 91325, United States More Info
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Torrance California, 90502, United States More Info
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Littleton Colorado, 80120, United States More Info
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Stamford Connecticut, 06905, United States More Info
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Boca Raton Florida, 33434, United States More Info
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Clearwater Florida, 33756, United States More Info
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Largo Florida, 33777, United States More Info
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Miami Florida, 33133, United States More Info
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Ocala Florida, 34471, United States More Info
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Safety Harbor Florida, 34695, United States More Info
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Saint Augustine Florida, 32086, United States More Info
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Atlanta Georgia, 30310, United States More Info
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Boise Idaho, 83712, United States More Info
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Arlington Heights Illinois, 60005, United States More Info
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Peoria Illinois, 61636, United States More Info
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Munster Indiana, 46321, United States More Info
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Overland Park Kansas, 66211, United States More Info
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Bossier City Louisiana, 71111, United States More Info
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Hammond Louisiana, 70403, United States More Info
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Shreveport Louisiana, 71105, United States More Info
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Baltimore Maryland, 21229, United States More Info
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Bay City Michigan, 48708, United States More Info
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Saint Louis Missouri, 63136, United States More Info
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Las Vegas Nevada, 89128, United States More Info
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Albuquerque New Mexico, 87102, United States More Info
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Buffalo New York, 14215, United States More Info
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Rochester New York, 14621, United States More Info
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Saratoga Springs New York, 12866, United States More Info
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Stony Brook New York, 11794, United States More Info
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Charlotte North Carolina, 28277, United States More Info
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Oklahoma City Oklahoma, 73102, United States More Info
Principal Investigator
Hillsboro Oregon, 97123, United States
Camp Hill Pennsylvania, 17011, United States More Info
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Doylestown Pennsylvania, 18901, United States More Info
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Pittsburgh Pennsylvania, 15213, United States More Info
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Charleston South Carolina, 29425, United States More Info
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Rapid City South Dakota, 57701, United States More Info
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Jackson Tennessee, 38301, United States More Info
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Dallas Texas, 75390, United States More Info
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McKinney Texas, 75069, United States More Info
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Sherman Texas, 75092, United States More Info
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Tomball Texas, 77375, United States More Info
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Murray Utah, 84107, United States More Info
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Puyallup Washington, 98372, United States More Info
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Morgantown West Virginia, 26506, United States More Info
Principal Investigator
Ramos Mejía Buenos Aires, B1704, Argentina More Info
Principal Investigator
San Nicolas Buenos Aires, 2900, Argentina More Info
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Ciudad Autónoma de Buenos Aire Buenos Air, C1027, Argentina More Info
Principal Investigator
Buenos Aires Ciudad Aut, C1128, Argentina More Info
Principal Investigator
Buenos Aires Ciudad Autónoma De Buenos Aire, C1061, Argentina More Info
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Ciudad Autonoma de Buenos Aire Ciudad Autónoma De Buenos Aire, C1425, Argentina More Info
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Rosario Santa Fe, 2000, Argentina More Info
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Buenos Aires , 1405, Argentina More Info
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Corrientes , 3400, Argentina More Info
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Córdoba , X5002, Argentina More Info
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Formosa , 3600, Argentina More Info
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Salta , 4400, Argentina More Info
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San Luis , 5700, Argentina More Info
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Santa Fe , S3000, Argentina More Info
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Goiania Goiás, 74605, Brazil More Info
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Campina Grande do Sul Paraná, 83430, Brazil More Info
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Aracaju Sergipe, 49055, Brazil More Info
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Campinas São Paulo, 13060, Brazil More Info
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Campinas São Paulo, 13060, Brazil More Info
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Campinas São Paulo, 13092, Brazil More Info
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Ribeirao Preto São Paulo, 14026, Brazil More Info
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Santo André São Paulo, 09080, Brazil More Info
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São José do Rio Preto São Paulo, 15090, Brazil More Info
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Rio de Janeiro , 20241, Brazil More Info
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São Paulo , 04266, Brazil More Info
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Beijing Beijing, 10003, China More Info
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Beijing Beijing, 10005, China More Info
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Lanzhou Gansu, 73003, China More Info
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Harbin Heilongjiang, 15000, China More Info
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Wuhan Hubei, 43000, China More Info
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Changsha Hunan, 41001, China More Info
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Baotou Inner Mongolia, 14010, China More Info
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Nanjing Jiangsu, 21000, China More Info
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Nanjing Jiangsu, 21001, China More Info
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Nanchang Jiangxi, 33000, China More Info
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Pingxiang Jiangxi, 33705, China More Info
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Changchun Jilin, 13002, China More Info
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Dalian Shi Liaoning, 11600, China More Info
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Shenyang Liaoning, 11000, China More Info
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Xi'an Shaanxi, 71006, China More Info
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Shanghai Shanghai, 20003, China More Info
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Shanghai Shanghai, 20004, China More Info
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Cheng Du Sichuan, 61004, China More Info
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Urumchi Xinjiang, 83005, China More Info
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New Delhi Delhi, 11000, India More Info
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New Delhi Delhi, 11006, India More Info
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Ahmedabad Gujarat, 38006, India More Info
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Mumbai Maharashtra, 40001, India More Info
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Nagpur Maharashtra, 44000, India More Info
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Nagpur Maharashtra, 44001, India More Info
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Nashik Maharashtra, 42200, India More Info
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Hyderabad Telangana, 50003, India More Info
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Ashkelon HaDarom, 78306, Israel More Info
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Ramat Gan HaMerkaz, 52621, Israel More Info
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Tel Aviv Tell Abīb, 64239, Israel More Info
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Jerusalem Yerushalayim, 90131, Israel More Info
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Jerusalem Yerushalayim, 91120, Israel More Info
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Torreón Coahuila, 27000, Mexico More Info
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Guadalajara Jalisco, 44670, Mexico More Info
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Monterrey Nuevo León, 64060, Mexico More Info
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Aguascalientes , 20230, Mexico More Info
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Aguascalientes , 20230, Mexico More Info
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Querétaro , 76000, Mexico More Info
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Bayamon , 00956, Puerto Rico More Info
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Ponce , 00717, Puerto Rico More Info
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Ivanovo Ivanovskay, 15301, Russian Federation More Info
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Moscow Moskva, 12155, Russian Federation More Info
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Moscow Moskva, 25128, Russian Federation More Info
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Ryazan Ryazanskaya Oblast', 39002, Russian Federation More Info
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Saint-Petersburg Sankt-Peterburg, 19922, Russian Federation More Info
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Izhevsk Udmurtskaya Respublika, 42606, Russian Federation More Info
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Taipei City Taipei, 10022, Taiwan More Info
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Kaohsiung , 807, Taiwan More Info
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Taichung , 402, Taiwan More Info
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Taipei R. O. C. , 112, Taiwan More Info
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Taipei , 110, Taiwan More Info
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Taoyuan , 333, Taiwan More Info
Principal Investigator
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