Assessment of Biomarkers and Cardiorenal Syndrome in Acute Decompensated Heart Failure With Vasodilator Therapy

Inclusion Criteria:

At least 18 years of age.
Subject must be able to understand the potential risks and benefits associated with the study.
Baseline systolic blood pressure ≥ 90 mm Hg at the time of enrollment.
Clinical symptoms of dyspnea and laboratory admission BNP levels > 500 pg/mL.
Neither pregnant or breastfeeding at the time of enrollment.
Authorization of patient's enrollment by patient's medical provider.

Exclusion Criteria:

<18 years of age
Denies written informed consent
Pregnant or lactating.
Baseline systolic BP < 90 mmHg or cardiogenic shock
No symptoms of congestion or admission BNP < 500 pg/mL
Known allergy to E.coli-derived products, or any history of anaphylactic reactions to nesiritide.
Receiving dialysis at the time of enrollment.
Serum creatinine > 2.5 mg/dL at the time of enrollment.