Heart Failure Clinical Trial
Depression and Self-care in Heart Failure
Summary
The purpose of the study is to test whether Cognitive Behavior Therapy (CBT) plus heart failure self-care education is superior to "usual care" for depression.
Full Description
Comorbid depression is common in heart failure, but little is known about how to treat it. This randomized, controlled, efficacy trial will compare cognitive behavior therapy (CBT) to usual care (UC) for depression in heart failure. CBT will be integrated with an intervention to improve heart failure self-care, because depression and inadequate self-care are thought to be interrelated problems. It will also be integrated with clinical attention to primary caregiver stress. Basic heart failure education will be provided to all participants.
Eligibility Criteria
Inclusion Criteria:
New York Heart Association Class I, II, or III Heart Failure (Clinically diagnosed at least 3 months ago)
Meets the DSM-IV criteria for a current major depressive episode, or for current minor depression with a past history of at least one major depressive episode.
PHQ-9 score of 10 or greater plus 2 or 3 on question 1 or 2 over the last 2 weeks including today
Exclusion Criteria:
Less than 30 years old
Current ETOH / drug abuse
Bipolar disorder, schizophrenia, or other psychotic disorder
Communication barrier
Dementia
Currently in competing research protocol
High risk for suicide
Insurmountable logistical barriers to laboratory assessment visits
Major mobility-limiting physical disability
Poor 1 year prognosis not r/t heart failure
Hospitalized for heart failure or acute coronary syndrome in last month
Initiated antidepressant therapy in the past 4 weeks
Current non-study psychotherapy for depression or other psychiatric problem
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There is 1 Location for this study
St. Louis Missouri, 63108, United States
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