Heart Failure Clinical Trial
Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg
Summary
The purpose of this study is to compare dosing compliance between study patients taking controlled release carvedilol once a day, and study patients taking immediate release carvedilol (Coreg) twice a day.
Full Description
Study Further Study Details:
Primary outcome: pill-taking compliance (total doses taken versus total doses prescribed)
Expected Total Enrollment: 400 subjects at 56 study sites in the U.S.
Study Start: October 2005
This is a 5-month double-blind treatment study of male and female subjects with stable mild-to-severe chronic heart failure and with left ventricular dysfunction with symptoms of heart failure.
Eligibility:
Must be stable on treatment with Coreg IR at a standard dose: 6.25, 12.5, 25 mg twice a day.
Eligibility Criteria
Inclusion Criteria:
Ability to read English
Stable symptoms of mild to severe heart failure
Stable medical regimen for heart failure
On a stable dose of Coreg for at least 2 months
LVEF ≤40% within the previous 24 months
Exclusion Criteria:
Uncorrected obstructive or regurgitant valve disease
Complex congenital heart disease
Recent ICD or pacemaker placement
Recent coronary artery bypass surgery or stroke
Candidate for heart transplanct within 5 months of study start
Present or planned use of MAO inhibitors, alfpha-blockers, combined alpha-beta blockers, any Class I/II anti-arrythmnic agents, (amiodarone may be used if ≤ 200mg/day). Use of intravenous vasodilator/inotropic agents.
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There are 54 Locations for this study
Mobile Alabama, 36608, United States
Sierra Vista Arizona, 85635, United States
Anaheim California, 92801, United States
Beverly Hills California, 90210, United States
Oakland California, 94609, United States
San Diego California, 34203, United States
Santa Rosa California, 95403, United States
Santa Rosa California, 95405, United States
Walnut Creek California, 94598, United States
Fort Collins Colorado, 80528, United States
Hartford Connecticut, 06105, United States
Miami Florida, 33126, United States
Port Charlotte Florida, 33952, United States
St. Petersburg Florida, 33701, United States
Atlanta Georgia, 30309, United States
Augusta Georgia, 30901, United States
Covington Georgia, 30014, United States
Boise Idaho, 83704, United States
Bannockburn Illinois, 60015, United States
Lombard Illinois, 60148, United States
Normal Illinois, 61761, United States
Indianapolis Indiana, 46260, United States
Metairie Louisiana, 70006, United States
Auburn Maine, 04210, United States
S.Portland Maine, 04106, United States
Scarborough Maine, 04074, United States
Ayer Massachusetts, 01432, United States
Burlington Massachusetts, 01805, United States
Haverhill Massachusetts, 01830, United States
Detroit Michigan, 48202, United States
Lincoln Nebraska, 68516, United States
Las Vegas Nevada, 89128, United States
Cherry Hill New Jersey, 08034, United States
Albuquerque New Mexico, 87131, United States
Albany New York, 12205, United States
Garden City New York, 11530, United States
Kingston New York, 12401, United States
New York New York, 10016, United States
West Islip New York, 11795, United States
Burlington North Carolina, 27215, United States
Akron Ohio, 44307, United States
Cincinnati Ohio, 45219, United States
Cincinnati Ohio, 45242, United States
Dayton Ohio, 45414, United States
Lorain Ohio, 44503, United States
Sandusky Ohio, 44870, United States
Bartlesville Oklahoma, 74006, United States
Corvallis Oregon, 97330, United States
Eugene Oregon, 97401, United States
Sayre Pennsylvania, 18840, United States
Providence Rhode Island, 02903, United States
Longview Texas, 75605, United States
Salt Lake City Utah, 84143, United States
Elkhorn Wisconsin, 53121, United States
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