Evaluation of Patiromer in Heart Failure Patients

Inclusion Criteria:

Participants with chronic heart failure clinically indicated to receive spironolactone therapy, aged 18 years or older with serum potassium level of 4.3 - 5.1 mEq/L at screening and baseline, AND (1) chronic kidney disease (GFR < 60 mL/min) OR (2) documented history of hyperkalemia within the last 6 months
Females of child-bearing potential must be non-lactating, must have a negative serum pregnancy test at screening, and must have used a highly effective form of contraception for at least 3 months before study drug administration, during the study, and for one month after study completion
Male participants and/or their female partners of child-bearing potential must use a highly effective form of contraception during the study and for 3 months after study completion
Must sign informed consent document

Exclusion Criteria:

History of bowel obstruction, swallowing disorders, severe gastrointestinal disorders or major gastrointestinal surgery
Uncorrected hemodynamically significant primary valvular disease, known obstructive or restrictive cardiomyopathy, uncontrolled or hemodynamically unstable arrhythmia
Coronary-artery bypass graft, percutaneous intervention (e.g. cardiac, cerebrovascular, aortic), or major surgery including thoracic and cardiac, within 3 months prior to baseline or anticipated need during study participation
Heart transplant recipient, or anticipated need for transplant during study participation
Any of the following events having occurred within 3 months prior to baseline: unstable angina as judged by the Investigator, unresolved acute coronary syndrome, transient ischemic attack or stroke
Current dialysis participant, or anticipated need for dialysis during study participation
Prior kidney transplant, or anticipated need for transplant during study participation
Metastatic, late-stage or end-stage cancer with < 12 months life expectancy
History of alcoholism or drug/chemical abuse within 1 year
QTcB interval > 500 msec (Bazett's correction formula)
Sustained systolic blood pressure > 170 or < 90 mmHg
Liver enzymes (ALT, AST) > 3 times upper limit of normal
Use of oral cardiac medications (including loop and thiazide diuretics) that have not been stable for at least 21 days prior to baseline and are not anticipated to remain stable during study participation
Use of any IV cardiac medications within 21 days prior to baseline, or their anticipated need during study participation.
Current use of polymer-based drugs (e.g. Renagel, Kayexalate, Welchol, Colestid), other phosphate binders or potassium binders, calcium supplements, antacids (eg TUMS, Maalox), or their anticipated need during study participation
Use of aldosterone antagonist in the last 30 days prior to baseline, unless was discontinued due to hyperkalemia
Use of potassium sparing medication and/or potassium supplements in the last 30 days prior to baseline
Use of any investigational medication, 30 days or 5 half-lives whichever is longer, prior to baseline
Participants who have taken investigational product in this study, or a previous patiromer study
Inability to consume the study medication, or, in the opinion of the Investigator, inability to comply with the protocol
In the opinion of the Investigator, any medical condition, uncontrolled systemic disease, serious intercurrent illness, or extenuating circumstance occurring or persisting, within 30 days prior to baseline, that would significantly decrease study compliance or jeopardize the safety of the participant or affect the validity of the trial results