Heart Failure Clinical Trial

Exercise Capacity Before and After AF Ablation in Patients With HFpEF

Summary

In a prospective, observational pilot study of patients scheduled for an atrial fibrillation (AF) ablation at the University of Vermont Medical Center the investigators will compare exercise capacity before and four months after AF ablation.

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Full Description

Patients ≥ 18 years of age who are scheduled for an AF ablation at the University of Vermont Medical Center will be screened for the following inclusion criteria: H2FpEF score of ≥ 6 (corresponding to ≥90% probability of HFpEF (19)) AND echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50% AND at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea). Exclusion criteria: (1) Life expectancy <12 months, (2) moderate or more valvular disease, (3) inability to walk on a treadmill. Patients with early recurrent AF (defined as AF after a 12-week post-procedural blanking period accounting for post-ablation inflammation) will be withdrawn from the study and not proceed to the 4 month follow up visit.

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Eligibility Criteria

Inclusion Criteria:

H2FpEF score of ≥ 6 (corresponding to >90% probability of HFpEF (19))
echocardiogram within the past 2 years that reported a LV ejection fraction ≥ 50%
at least one symptom of HF (dyspnea on exertion, orthopnea or paroxysmal nocturnal dyspnea).
AF ablation scheduled at UVMMC

Exclusion Criteria:

Life expectancy <12 months
moderate or more valvular disease
inability to walk on a treadmill

Study is for people with:

Heart Failure

Estimated Enrollment:

34

Study ID:

NCT05376748

Recruitment Status:

Recruiting

Sponsor:

University of Vermont

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There is 1 Location for this study

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University of Vermont Medical Center
Burlington Vermont, 05405, United States More Info
Nicole Habel, MD
Contact
[email protected]

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Study is for people with:

Heart Failure

Estimated Enrollment:

34

Study ID:

NCT05376748

Recruitment Status:

Recruiting

Sponsor:


University of Vermont

How clear is this clinincal trial information?

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