Heart Failure Clinical Trial
Heart Pressure Assessment Study With Tolvaptan to Treat Congestive Heart Failure
Summary
This study will look at how a single dose of study medication (tolvaptan) versus an inactive sugar pill (placebo) effect pressures in the heart in patients with congestive heart failure. Higher than normal pressures can be related to symptoms of heart failure (shortness of breath, fatigue, etc.).
Eligibility Criteria
Inclusion Criteria:
Diagnosed with Class III or IV heart failure for at least 3 months
Left ventricular ejection fraction less than or equal to 40%
Currently being treated for heart failure with standard therapies for at least one month
Exclusion Criteria:
Women who are pregnant or breastfeeding
Inability to take oral medications
Uncontrolled hypertension, bradyarrhythmias or tachyarrhythmias
Hypertrophic obstructive cardiomyopathy
Severe obstructive pulmonary disease
Significant renal impairment
Significant uncorrected valvular or congenital heart disease
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There are 28 Locations for this study
Huntsville Alabama, 35801, United States
Merced California, 95340, United States
Sylmar California, 91324, United States
Ft. Lauderdale Florida, 33316, United States
Jacksonville Florida, 32209, United States
Tampa Florida, 33606, United States
Atlanta Georgia, 30342, United States
Chicago Illinois, 60612, United States
Chicago Illinois, 60612, United States
Maywood Illinois, 60153, United States
Iowa City Iowa, 52242, United States
Slidell Louisiana, 70458, United States
Slidell Louisiana, 70458, United States
Ayer Massachusetts, 01432, United States
Worchester Massachusetts, 01655, United States
Detroit Michigan, 48202, United States
St. Louis Missouri, 63110, United States
Omaha Nebraska, 68122, United States
Newark New Jersey, 07103, United States
Chapel Hill North Carolina, 27517, United States
Cincinnati Ohio, 45267, United States
Cleveland Ohio, 44106, United States
Portland Oregon, 97239, United States
Syre Pennsylvania, 18840, United States
Houston Texas, 77702, United States
Orange Texas, 77702, United States
Bucuresti , 01446, Romania
Bucuresti , 02232, Romania
Bucuresti , Cod 0, Romania
Judetul Cluj , Cod 4, Romania
Judetul Mures , Cod 5, Romania
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