Heart Failure Clinical Trial
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)
Summary
Objective of the study is to find the optimal dose of the once daily oral soluble guanylate cyclase stimulator (sGC) BAY1021189 for Phase III that can be given in addition to standard therapy for heart failure with reduced ejection fraction (HFrEF).
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Worsening chronic heart failure (WCHF) requiring hospitalization (or intravenous diuretic treatment for HF without hospitalization) with initiation of study treatment after clinical stabilization
Left ventricular ejection fraction (LVEF) <45% by echocardiography at randomization
Exclusion Criteria:
Intravenous inotropes at any time after hospitalization
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There are 154 Locations for this study
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Fountain Valley California, 92708, United States
Wilmington Delaware, 19803, United States
Fort Lauderdale Florida, 33308, United States
Jacksonville Florida, 32209, United States
Naples Florida, 34102, United States
Atlanta Georgia, 30342, United States
Macon Georgia, 31201, United States
New Orleans Louisiana, 70112, United States
Detroit Michigan, 48202, United States
Minneapolis Minnesota, 55422, United States
Jackson Mississippi, 39216, United States
Buffalo New York, 14215, United States
Columbus Ohio, 43210, United States
Fairfield Ohio, 45014, United States
Charleston South Carolina, 29425, United States
Germantown Tennessee, 38138, United States
Nashville Tennessee, 37232, United States
Milwaukee Wisconsin, 53215, United States
Darlinghurst New South Wales, 2010, Australia
Hobart Tasmania, 7000, Australia
Prahran Victoria, 3181, Australia
St. Pölten Niederösterreich, 3100, Austria
Linz Oberösterreich, 4020, Austria
Graz Steiermark, 8036, Austria
Salzburg , 5020, Austria
Wien , 1220, Austria
Brugge , 8000, Belgium
Bruxelles - Brussel , 1200, Belgium
Gent , 9000, Belgium
Gilly , 6060, Belgium
HUY , 4500, Belgium
Mechelen , 2800, Belgium
MOL , 2400, Belgium
Roeselare , 8800, Belgium
Sofia , 1202, Bulgaria
Sofia , 1233, Bulgaria
Sofia , 1309, Bulgaria
Sofia , 1527, Bulgaria
Stara Zagora , 6000, Bulgaria
Toronto Ontario, M5B 1, Canada
Montreal Quebec, H1T 1, Canada
Montreal Quebec, H2W 1, Canada
Saint-Jean-sur-Richelieu Quebec, J3A 1, Canada
Sherbrooke Quebec, J1G 2, Canada
Quebec , G1V 4, Canada
Hradec kralove , 500 0, Czechia
Kromeriz , 767 0, Czechia
Fakultni nemocnice Ostrava
Ostrava , 708 5, Czechia
Ostrava , 708 5, Czechia
Praha 10 , 10034, Czechia
Praha 2 , 12808, Czechia
Praha 4 , 140 2, Czechia
Praha 6 , 169 0, Czechia
Slany , 274 0, Czechia
Aalborg , 9000, Denmark
Aarhus N , 8200, Denmark
Hellerup , DK-29, Denmark
Viborg , 8800, Denmark
BRON Cedex , 69677, France
La Tronche , 38700, France
Lille Cedex , 59037, France
Paris Cedex 15 , 75908, France
Pessac , 33604, France
Rouen , 76031, France
München Bayern, 80331, Germany
Bad Homburg Hessen, 61348, Germany
Frankfurt Hessen, 60596, Germany
Greifswald Mecklenburg-Vorpommern, 17475, Germany
Hannover Niedersachsen, 30625, Germany
Köln Nordrhein-Westfalen, 50924, Germany
Münster Nordrhein-Westfalen, 48149, Germany
Homburg Saarland, 66424, Germany
Erfurt Thüringen, 99089, Germany
Hamburg , 20246, Germany
Athens , 11527, Greece
Nea Ionia , 14233, Greece
Budapest , 1032, Hungary
Kistarcsa , H-214, Hungary
Szekesfehervar , 8000, Hungary
Afula , 18341, Israel
Ashkelon , 78306, Israel
Hadera , 38101, Israel
Jerusalem , 91031, Israel
Petah Tikva , 49414, Israel
Rehovot , 76100, Israel
Tel Aviv , 64239, Israel
Tiberias , 15280, Israel
Zrifin , 70300, Israel
Bergamo Lombardia, 24127, Italy
Brescia Lombardia, 25123, Italy
Como Lombardia, 22020, Italy
Milano Lombardia, 20017, Italy
Milano Lombardia, 20138, Italy
Milano Lombardia, 20149, Italy
Pavia Lombardia, 27100, Italy
Ancona Marche, 60126, Italy
Arezzo Toscana, 52040, Italy
Verona Veneto, 37045, Italy
Iizuka Fukuoka, 820-8, Japan
Himeji Hyogo, 670-0, Japan
Kanazawa Ishikawa, 920-8, Japan
Sagamihara Kanagawa, 252-5, Japan
Yokohama Kanagawa, 236-0, Japan
Yokosuka Kanagawa, 238-8, Japan
Sendai Miyagi, 981-3, Japan
Naha Okinawa, 902-8, Japan
Takatsuki Osaka, 569-1, Japan
Yao Osaka, 581-0, Japan
Ureshino Saga, 843-0, Japan
Komatsushima Tokushima, 773-8, Japan
Meguro-ku Tokyo, 152-8, Japan
Minato-ku Tokyo, 106-0, Japan
Fukui , 910-8, Japan
Hiroshima , 734-8, Japan
Kumamoto , 862-8, Japan
Nagasaki , 850-8, Japan
Tokushima , 770-8, Japan
Toyama , 930-8, Japan
Seoul , 138-7, Korea, Republic of
Amsterdam , 1105 , Netherlands
Deventer , 7416 , Netherlands
Heerenveen , 8441 , Netherlands
Leeuwarden , 8901 , Netherlands
Veldhoven , 5504 , Netherlands
Bialystok , 15-27, Poland
Krakow , 31-20, Poland
Legnica , 59-22, Poland
Lodz , 92-21, Poland
Olsztyn , 10-01, Poland
Poznan , 61-84, Poland
Warszawa , 02-50, Poland
Singapore , 11922, Singapore
Singapore , 16960, Singapore
Singapore , 30843, Singapore
Singapore , 76882, Singapore
L'Hospitalet de Llobregat Barcelona, 08907, Spain
Santander Cantabria, 39008, Spain
Majadahonda Madrid, 28222, Spain
Barcelona , 08003, Spain
Barcelona , 08023, Spain
Valencia , 46010, Spain
Valencia , 46026, Spain
Helsingborg , 251 8, Sweden
Karlstad , 651 8, Sweden
Linköping , 581 8, Sweden
Malmö , 205 0, Sweden
Stockholm , 118 8, Sweden
Örebro , 701 8, Sweden
Liestal Basel-Landschaft, 4410, Switzerland
Bruderholz , 4101, Switzerland
Lugano , 6900, Switzerland
Zürich , 8091, Switzerland
Kaohsiung , 813, Taiwan
New Taipei City , 220, Taiwan
Taipei , 10016, Taiwan
Taipei , 11217, Taiwan
Chesterfield Derbyshire, S44 5, United Kingdom
Stevenage Hertfordshire, SG1 4, United Kingdom
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