REDUCE LAP-HF RANDOMIZED TRIAL I

Key Inclusion Criteria:

Chronic symptomatic Heart Failure
Ongoing stable GDMT HF management and management of potential comorbidities
Age ≥ 40 years old
LV ejection fraction ≥ 40% within the past 3 months, without previously documented ejection fraction <30%.
Elevated left atrial pressure with a gradient compared to right atrial pressure (RAP) documented by end-expiratory PCWP during supine ergometer exercise ≥ 25mm Hg, and greater than RAP by ≥ 5 mm Hg

Key Exclusion Criteria:

MI and/or percutaneous cardiac intervention within past 3 months; CABG in past 3 months, or current indication for coronary revascularization
Cardiac Resynchronization Therapy initiated within the past 6 months
Severe heart failure
Inability to perform 6 minute walk test (distance < 50 m), OR 6 minute walk test > 600m
History of stroke, transient ischemic attack (TIA), deep vein thrombosis (DVT), or pulmonary emboli within the past 6 months
Presence of significant valve disease
Known clinically significant untreated carotid artery stenosis
Currently requiring dialysis; or estimated-GFR <25ml/min/1.73 m2 by CKD-Epi equation