Sacubitril/Valsartan Treated Adult Patients With Chronic Heart Failure

Inclusion Criteria:

Cohort 1 - Adult HFrEF patients

Newly initiated sacubitril/valsartan during the cohort identification period;
Presence of an International Classification of Diseases, Tenth revision (ICD-10) diagnosis code for systolic HF (I50.1x, I50.2x, I50.4x) on one inpatient hospital claim or two outpatient medical claims during the cohort identification period;
That are ≥ 18 years old at index date;
That are treated with sacubitril/valsartan continuously for a minimum of 90-days following treatment initiation;
That are continuously enrolled in medical and prescription pharmacy benefits in both the pre-index and post-index period, with any gap in coverage of <45 days allowed.

Cohort 2 - Adult CHF patients

Newly initiated sacubitril/valsartan during the cohort identification period;
Presence of ICD-10 diagnosis code for systolic HF or diastolic HF (I50.1x, I50.2x, I50.3x, I50.4x) on one inpatient hospital claim or two outpatient medical claims during the cohort identification period;
That are ≥ 18 years old at index date;
That are treated with sacubitril/valsartan continuously for a minimum of 90-days following treatment initiation;
That are continuously enrolled in medical and prescription pharmacy benefits in both the pre-index and post-index period, with any gap in coverage of <45 days allowed.

Exclusion Criteria:

- Patients who died during the post-index period will be excluded.