SGLT2 Inhibition in Diabetes and Heart Failure

Inclusion Criteria:

Confirmed clinical diagnosis of stable HF (NYHA class II-III) on maximally tolerated HF medical regimen including angiotensin-inhibitors, beta-adrenergic blockers, and loop diuretics
Reduced left ventricular systolic function (LVEF<50%) documented in the prior 12 months
Poorly controlled T2DM (HbA1c levels between 6.5% and 10.0%)
18 years old and older.

Exclusion Criteria:

Type I diabetes;
Type II diabetes with episodes of severe hypoglycemia <50 mg/dl by history, frequent changes in anti-diabetic regimen class in the past 3 months or with a prior episode of diabetic ketoacidosis (any time);
Open label treatment with SGLT2 inhibitors (within the past month);
Treatment with thiazolidinedione (within the past month), which may induce volume and sodium retention;
Chronic Kidney Disease (GFR<45 ml/kg*min);
Uncontrolled thyroid dysfunction (TSH<0.4>4.5 mcIU/ml);
Pregnancy or of child-bearing potential;
Active or recent (within 2 weeks) genital/urinal infection;
Concomitant conditions or treatment which would affect completion or interpretation of the study including physical inability to walk or run on a treadmill such as decompensated HF (edema, NYHA class IV), significant ischemic heart disease, angina, arterial hypotension (BP systolic <90 mmHg), orthostatic arterial hypotension, arterial hypertension (resting BP systolic >160 mmHg), atrial fibrillation with rapid ventricular response, severe valvular disease, severe chronic obstructive or restrictive pulmonary disease, moderate- severe anemia (Hgb<10 g/dl);
Abnormal BP or heart rate response, angina or ECG changes (ischemia or arrhy- thmias) occurring during baseline cardio-pulmonary exercise testing;
Chronic use of oral corticosteroids;
Inability to give informed consent.