Heart Failure Clinical Trial
Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease
Summary
Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
Full Description
The broad objective of this proposal is to characterize the dynamic changes in cardiopulmonary mechanics during stress in patients with exertional dyspnea, establishing a comprehensive multimodality diagnostic approach to the evaluation of exercise intolerance.
The specific objective is to prospectively compare established and novel parameters derived from echocardiography and CPX with simultaneous, gold standard invasive measures of cardiovascular hemodynamics at rest and with exercise stress to define the role of noninvasive testing in the diagnostic workup.
The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
Eligibility Criteria
Inclusion Criteria:
exertional intolerance/dyspnea of unknown etiology
referral to cardiac catheterization laboratory
undergoing invasive hemodynamic evaluation for clinical purposes
Exclusion Criteria:
hypertrophic cardiomyopathy
constrictive pericarditis
infiltrative myopathy (e.g. amyloid)
congenital heart disease
resting LVEF <50%
> moderate mitral annular calcification
moderate or greater left-sided valvular stenosis or regurgitation
prior valve surgery
basal septal wall motion abnormalities
>70% epicardial coronary artery stenosis
right ventricular infarction
pregnancy
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There is 1 Location for this study
Rochester Minnesota, 55905, United States
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