Heart Failure Clinical Trial

Vitamin C Supplementation Intervention

Summary

This study is to test a low-cost, simple vitamin C supplementation intervention, that is, comparing placebo to 500 mg/day vitamin C and 1 gram/day vitamin C daily to assess feasibility and acceptability of vitamin C supplementation and effects on serum vitamin C level, health-related quality of life (HRQOL), symptom burden, oxidative stress, and cardiac function.

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Full Description

This study will address feasibility from the perspective of being able to: a) to detect significant differences in the serum vitamin C level after supplementation (3 months) between the intervention groups and the control group, b) to detect significant differences in health related quality of life (HRQOL), symptom burden, oxidative stress, and cardiac function after vitamin C supplementation (3 months) between the intervention groups and the control group.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patents recruited will have a diagnosis of chronic HF, either preserved or reduced ejection fraction. The diagnosis and etiology of chronic HF will be confirmed by a HF cardiologist using established criteria.

Other criteria:

have undergone evaluation of HF and optimization of medical therapy,
vitamin C supplementation <500 mg/day
have not been referred for heart transplantation,
able to read and speak English,
>1 month from any inpatient hospitalization

Exclusion Criteria:

history of renal stones or renal disease (serum creatinine >1.5,
history of glucose-6-phosphate dehydrogenase deficiency (G6PD) and cognitive impairment that precludes giving informed consent or ability to follow protocol instructions
pregnant

Study is for people with:

Heart Failure

Estimated Enrollment:

36

Study ID:

NCT04036110

Recruitment Status:

Completed

Sponsor:

University of North Carolina, Chapel Hill

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There is 1 Location for this study

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UNCH Meadowmont Clinic
Chapel Hill North Carolina, 27517, United States

How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Estimated Enrollment:

36

Study ID:

NCT04036110

Recruitment Status:

Completed

Sponsor:


University of North Carolina, Chapel Hill

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