Kidney Cancer Clinical Trial
A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies
Summary
To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.
Full Description
This is a multicenter, open-label, Phase 1/2 study to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of MEDI0680 in combination with durvalumab or nivolumab monotherapy in adult immunotherapy-naïve participants with selected advanced malignancies.
Eligibility Criteria
Inclusion Criteria:
Must be 18 years or older
Eastern Cooperative Oncology Group performance status of 0-1
Adequate organ function
At least 1 prior line of therapy
Exclusion Criteria:
Concurrent enrollment in another clinical study, unless in follow-up period or it is an observational study
Concurrent chemotherapy, immunotherapy, biologic, or hormonal therapy for cancer treatment
Prior treatment with immunotherapy
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There are 27 Locations for this study
Los Angeles California, 90025, United States
Tampa Florida, 33612, United States
Overland Park Kansas, 66209, United States
Louisville Kentucky, 40202, United States
Rochester Minnesota, 55905, United States
Hackensack New Jersey, 07601, United States
New York New York, 10065, United States
Cleveland Ohio, 44195, United States
Oklahoma City Oklahoma, 73104, United States
Portland Oregon, 97213, United States
Hershey Pennsylvania, 17033, United States
Nashville Tennessee, 37203, United States
Seattle Washington, 98109, United States
East Bentleigh , 3165, Australia
Frankston , 3199, Australia
Toronto Ontario, M5G 2, Canada
Montreal Quebec, H3T 1, Canada
Bordeaux , 33075, France
Dijon , 21079, France
Marseille , 13009, France
Paris Cedex 15 , 75908, France
Villejuif , 94805, France
Amsterdam , 1066 , Netherlands
Groningen , 9713 , Netherlands
Cambridge , CB2 0, United Kingdom
Cardiff , CF14 , United Kingdom
Southampton , SO16 , United Kingdom
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