Kidney Cancer Clinical Trial

A Phase 1/2, Open-label Study to Evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination With Durvalumab Versus Nivolumab Monotherapy in Participants With Select Advanced Malignancies

Summary

To evaluate the Safety and Antitumor Activity of MEDI0680 (AMP-514) in Combination with Durvalumab versus Nivolumab Monotherapy in Participants with Select Advanced Malignancies.

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Full Description

This is a multicenter, open-label, Phase 1/2 study to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of MEDI0680 in combination with durvalumab or nivolumab monotherapy in adult immunotherapy-naïve participants with selected advanced malignancies.

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Eligibility Criteria

Inclusion Criteria:

Must be 18 years or older
Eastern Cooperative Oncology Group performance status of 0-1
Adequate organ function
At least 1 prior line of therapy

Exclusion Criteria:

Concurrent enrollment in another clinical study, unless in follow-up period or it is an observational study
Concurrent chemotherapy, immunotherapy, biologic, or hormonal therapy for cancer treatment
Prior treatment with immunotherapy

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

97

Study ID:

NCT02118337

Recruitment Status:

Completed

Sponsor:

MedImmune LLC

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There are 27 Locations for this study

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Research Site
Los Angeles California, 90025, United States
Research Site
Tampa Florida, 33612, United States
Research Site
Overland Park Kansas, 66209, United States
Research Site
Louisville Kentucky, 40202, United States
Research Site
Rochester Minnesota, 55905, United States
Research Site
Hackensack New Jersey, 07601, United States
Research Site
New York New York, 10065, United States
Research Site
Cleveland Ohio, 44195, United States
Research Site
Oklahoma City Oklahoma, 73104, United States
Research Site
Portland Oregon, 97213, United States
Research Site
Hershey Pennsylvania, 17033, United States
Research Site
Nashville Tennessee, 37203, United States
Research Site
Seattle Washington, 98109, United States
Research Site
East Bentleigh , 3165, Australia
Research Site
Frankston , 3199, Australia
Research Site
Toronto Ontario, M5G 2, Canada
Research Site
Montreal Quebec, H3T 1, Canada
Research Site
Bordeaux , 33075, France
Research Site
Dijon , 21079, France
Research Site
Marseille , 13009, France
Research Site
Paris Cedex 15 , 75908, France
Research Site
Villejuif , 94805, France
Research Site
Amsterdam , 1066 , Netherlands
Research Site
Groningen , 9713 , Netherlands
Research Site
Cambridge , CB2 0, United Kingdom
Research Site
Cardiff , CF14 , United Kingdom
Research Site
Southampton , SO16 , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

97

Study ID:

NCT02118337

Recruitment Status:

Completed

Sponsor:


MedImmune LLC

How clear is this clinincal trial information?

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