Kidney Cancer Clinical Trial

A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)

Summary

This phase II trial studies how well axitinib and nivolumab work in treating patients with TFE/translocation renal cell carcinoma that cannot be removed by surgery (unresectable) or has spread to other places in the body (metastatic). Axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving axitinib and nivolumab may work better in treating patients with TFE/translocation renal cell carcinoma compared to standard treatment, including surgery, chemotherapy, or immunotherapy.

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Full Description

PRIMARY OBJECTIVE:

I. To establish the clinical activity, assessed primarily by progression-free survival, of nivolumab therapy with or without axitinib for advanced transcription factor E3/translocation morphology renal cell carcinoma (TFE/tRCC).

SECONDARY OBJECTIVE:

I. To further define the toxicities of the study arms in the treatment of translocation morphology RCC across all ages.

EXPLORATORY OBJECTIVES:

I. To characterize tRCC clinical behavior across all age groups. II. To evaluate type of antitumor immune response and stability of T cell activation before and after treatment with immunotherapy or antiangiogenic therapy.

III. To develop a tumor bank of tRCC tumor samples treated on study for further biological investigations.

IV. To characterize the pharmacokinetics of axitinib when given in combination with nivolumab in pediatric patients with tRCC.

OUTLINE: Patients are now randomized to 1 of 2 arms - Arm A or Arm C.

ARM A: Patients receive axitinib orally (PO) twice daily (BID) on days 1-28 and nivolumab intravenously (IV) over 30 minutes, or per institutional guidelines, on days 1 and 15 (if < 18 years old) or on day 1 (if >= 18 years old). Treatment repeats every 28 days for up to 26 cycles (2 years) in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive axitinib PO BID on days 1-28. Treatment repeats every 28 days for up to 26 cycles (2 years) in the absence of disease progression or unacceptable toxicity. (CLOSED TO ACCRUAL AS OF 1/23/2020 - PROSPECTIVE PATIENTS ARE RANDOMLY ASSIGNED TO ARMS A OR C)

ARM C: Patients receive nivolumab IV over 30 minutes, or per institutional guidelines, on days 1 and 15 (if < 18 years old) or on day 1 (if >= 18 years old). Treatment repeats every 28 days for up to 26 cycles (2 years) in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year, every 4 months for 1 year, and every 6 months for 2 years. Follow-up at year 5 and beyond is at the discretion of the treating physician.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients must be >= 12 months at enrollment
Patients must have a body surface area (BSA) >= 0.53 m^2

Histologically confirmed unresectable or metastatic translocation morphology renal cell carcinoma diagnosed using World Health Organization (WHO)-defined criteria. Patients may be newly diagnosed or have received prior cancer therapy

Patients must have had histologic verification of the malignancy
Patients must have measurable disease, documented by clinical, radiographic, or histologic criteria as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1
Patients must have a tumor showing the appropriate morphologic appearance, and either confirmed TFE3 nuclear protein expression by immunohistochemistry with appropriate positive and negative controls performed at a Clinical Laboratory Improvement Act (CLIA)-certified laboratory, or evidence of TFE3 or TFEb translocation by either fluorescence in situ hybridization (FISH) or reverse transcriptase- polymerase chain reaction (RT-PCR) performed at a CLIA-certified laboratory. For TFE3 immunohistochemistry, any nuclear positivity in the presence of appropriate positive and negative controls should be considered as evidence of TFE3 immunohistochemical expression. NOTE: If the institution is unable to perform these studies, unstained slides may be submitted to Dr. Elizabeth Perlman, who will perform TFE3 analysis at no charge. The slide will be returned to the referring institution for local evaluation, to be included in their institutional report
Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1 or 2. Use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age
Patients must have a life expectancy of >= 8 weeks

Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study

Myelosuppressive chemotherapy: Must not have received within 2 weeks of entry onto this study (6 weeks if prior nitrosourea)
Immunotherapy: Must not have received within 4 weeks of entry onto this study
Biologic (anti-neoplastic agent): At least 7 days since the completion of therapy with a biologic agent
Radiation therapy (RT): >= 2 weeks for local palliative RT (small port); >= 6 months must have elapsed if prior craniospinal RT or if >= 50% radiation of pelvis; >= 6 weeks must have elapsed if other substantial bone marrow (BM) radiation
Peripheral absolute neutrophil count (ANC) >= 1000/uL (performed within 7 days prior to enrollment)
Platelet count >= 75,000/uL (transfusion independent) (performed within 7 days prior to enrollment)
Hemoglobin >= 8.0 g/dL (may receive red blood cell [RBC] transfusions) (performed within 7 days prior to enrollment)
Urine protein: =< 30 mg/dL in urinalysis or =< 1+ on dipstick, unless quantitative protein is < 1000 mg in a 24 hours (h) urine sample (performed within 7 days prior to enrollment)

For patients < 18 years of age: Serum creatinine =< 1.5 x upper limit of normal (ULN), or measured or calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 60 mL/min/1.73 m^2 for patient with creatinine levels > 1.5 x institutional ULN, or a serum creatinine based on age/gender as follows (performed within 7 days prior to enrollment):

1 to < 2 years - 0.6 mg/dL (male, female)
2 to < 6 years - 0.8 mg/dL (male, female)
6 to < 10 years - 1 mg/dL (male, female)
10 to < 13 years - 1.2 mg/dL (male, female)
13 to < 16 years - 1.5 mg/dL (male), 1.4 mg/dL (female)
>= 16 years - 1.7 mg/dL (male), 1.4 mg/dL (female)
Creatinine clearance should be calculated per institutional standard

For patients >= 18 years of age: Serum creatinine =< 2 x ULN, or measured or calculated creatinine clearance or radioisotope GFR >= 40 mL/min/1.73 m^2 for patient with creatinine levels > 2 x institutional ULN (performed within 7 days prior to enrollment)

Creatinine clearance should be calculated per institutional standard
Serum total bilirubin =< 1.5 x ULN for age, or direct bilirubin =< ULN for patients with total bilirubin levels > 1.5 X ULN (performed within 7 days prior to enrollment)
Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 3 x ULN for age (performed within 7 days prior to enrollment)
Albumin > 2.5 mg/dL (performed within 7 days prior to enrollment)
Shortening fraction of >= 27% by echocardiogram, or
Ejection fraction of >= 50% by radionuclide angiogram
No history of myocardial infarction, severe or unstable angina, or peripheral vascular disease
Corrected QT (QTc) =< 480 msec. Note: Patients with grade 1 prolonged QTc (450-480 msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e., electrolytes, medications)
International normalized ratio (INR) or prothrombin time (PT) =< 1.5 X ULN. However, if patient is receiving anticoagulant therapy, PT or partial thromboplastin time (PTT) should be within therapeutic range of intended use of anticoagulants
Activated partial thromboplastin time (aPTT) =< 1.5 X ULN unless patient is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants

A baseline blood pressure (BP) =< the 95th percentile for age, height, and gender for patients < 18 years old, or =< 150 mmHg (systolic) and =< 90 mmHg (diastolic) for patients >= 18 years old

Note: 2 serial blood pressures should be taken at least 1 hour apart and averaged to determine baseline BP
Patients are eligible if on stable doses (>= 7 days) of anti-hypertensive medications with a baseline BP meeting the criteria above

Exclusion Criteria:

Patients unable to swallow whole tablets
Patients who in the opinion of the investigator are not able to comply with the study procedures are not eligible

Prior Therapy

Patients who have received prior therapy with axitinib, nivolumab, or other PD1/PD-L1 targeted therapies
Patients who have received prior therapy with more than one anti VEGF based agent (antibody or tyrosine kinase inhibitor)
Patients with hypersensitivity to axitinib, nivolumab, or any of its excipients
Patients who previously received an allogeneic stem cell transplant (SCT) or solid organ transplant are not eligible
Patients may not be receiving any other investigational agents (within 4 weeks prior to study enrollment)
Patients who have received prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study enrollment or who have not recovered (i.e., =< grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks prior to enrollment

Surgery: Patients who have had or who are planning to have the following invasive procedures are not eligible:

Major surgical procedure, laparoscopic procedure, open biopsy, core biopsy, fine needle aspirate, or significant traumatic injury within 7 days prior to enrollment. NOTE: External central lines must be placed at least 3 days prior to planned treatment initiation and subcutaneous ports must be placed at least 7 days prior to planned treatment initiation
Patients who are planning cytoreductive surgery within the first 12 weeks following therapy initiation
Patients who have a serious or non-healing wound or ulcer at the time of study enrollment are not eligible
Patients who have a history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 28 days of study enrollment are not eligible
Patients who have received prior targeted small molecule therapy within 2 weeks of enrollment or have not recovered (i.e., =< grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks prior to enrollment. NOTE: Subjects with =< grade 2 neuropathy are an exception to this criterion and may qualify for the study

Pre-existing conditions, which may include:

Additional known malignancy that is progressing or requires active treatment. Exceptions include basal cell carcinoma of the skin, or squamous cell carcinoma of the skin that has undergone potentially curative therapy, or in situ cervical cancer
Patients with underlying immune deficiency, chronic infections including hepatitis, tuberculosis (TB), or autoimmune disease
Human immunodeficiency virus (HIV)-infected patients with the exception of patients on an effective anti-retroviral therapy with an undetectable viral load within 6 months prior to enrollment
Patients with underlying hematologic issues including congenital bleeding diathesis, known previous gastrointestinal (GI) bleeding requiring intervention within the past 6 months, history of hemoptysis within 42 days prior to study enrollment, active pulmonary emboli, or deep vein thromboses (DVT) that are not stable on anticoagulation regimen
Patients must not have had significant vascular disease (i.e. Moya-Moya, aortic aneurysm requiring surgical repair)
A known history of, or any evidence of active, non-infectious pneumonitis
Patients with known active central nervous system (CNS) metastases and/or carcinomatous meningitis or leptomeningeal disease. Patients with previously treated brain metastases may participate provided they are stable (without evidence of progression by imaging for at least 4 weeks prior to study enrollment and any neurologic symptoms have returned to baseline), have no evidence of new or enlarging brain metastases, and are not using steroids for at least 7 days prior to study enrollment. This exception does not include carcinomatous meningitis which is excluded regardless of clinical stability
Any uncontrolled, intercurrent illness including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia
Any serious medical or psychiatric illness/condition including substance use disorders likely in the judgment of the investigator(s) to interfere or limit compliance with study requirements/treatment
Patients with active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment

Treatments and/or medications the patient is receiving or has received that would make her/him ineligible, including:

Concomitant (or receipt of) treatment with medications that may affect the metabolism of nivolumab and/or axitinib within 7 days prior to planned first dose of protocol therapy
A live vaccine within 30 days of planned first dose of protocol therapy. NOTE: Inactivated flu vaccines are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed

Pregnancy and breast feeding

Due to risks of fetal and teratogenic adverse events as seen in animal studies, a negative pregnancy test must be obtained in females of childbearing potential, defined as females who are post-menarchal. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required
Females of childbearing potential that are sexually active must agree to either practice 2 medically accepted highly-effective methods of contraception at the same time or abstain from heterosexual intercourse from the time of signing the informed consent through 5 months after the last dose of study drug
Lactating females are not eligible unless they have agreed not to breastfeed their infants starting with the first dose of study therapy through 5 months after the last dose of study therapy
Male patients of reproductive potential must agree to use an adequate method of contraception starting with the first dose of study therapy through 7 months after the last dose of study therapy. Prior history of vasectomy does not replace requirement for contraceptive use

Regulatory requirements

All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Study is for people with:

Kidney Cancer

Phase:

Phase 2

Estimated Enrollment:

40

Study ID:

NCT03595124

Recruitment Status:

Active, not recruiting

Sponsor:

National Cancer Institute (NCI)

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There are 221 Locations for this study

See Locations Near You

Children's Hospital of Alabama
Birmingham Alabama, 35233, United States
CTCA at Western Regional Medical Center
Goodyear Arizona, 85338, United States
Cancer Center at Saint Joseph's
Phoenix Arizona, 85004, United States
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs Arkansas, 71913, United States
Arkansas Children's Hospital
Little Rock Arkansas, 72202, United States
Kaiser Permanente-Anaheim
Anaheim California, 92806, United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande California, 93420, United States
PCR Oncology
Arroyo Grande California, 93420, United States
Kaiser Permanente-Bellflower
Bellflower California, 90706, United States
Mercy Cancer Center - Carmichael
Carmichael California, 95608, United States
Mercy San Juan Medical Center
Carmichael California, 95608, United States
Kaiser Permanente Downey Medical Center
Downey California, 90242, United States
Mercy Cancer Center - Elk Grove
Elk Grove California, 95758, United States
Kaiser Permanente-Fontana
Fontana California, 92335, United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles California, 90027, United States
Mattel Children's Hospital UCLA
Los Angeles California, 90095, United States
Kaiser Permanente-Oakland
Oakland California, 94611, United States
Children's Hospital of Orange County
Orange California, 92868, United States
Mercy Cancer Center - Rocklin
Rocklin California, 95765, United States
Mercy Cancer Center - Sacramento
Sacramento California, 95816, United States
University of California Davis Comprehensive Cancer Center
Sacramento California, 95817, United States
Kaiser Permanente-San Diego Mission
San Diego California, 92108, United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo California, 93401, United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria California, 93444, United States
Woodland Memorial Hospital
Woodland California, 95695, United States
Children's Hospital Colorado
Aurora Colorado, 80045, United States
UCHealth University of Colorado Hospital
Aurora Colorado, 80045, United States
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs Colorado, 80907, United States
Saint Francis Cancer Center
Colorado Springs Colorado, 80923, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver Colorado, 80218, United States
Mercy Medical Center
Durango Colorado, 81301, United States
Southwest Oncology PC
Durango Colorado, 81301, United States
Mountain Blue Cancer Care Center
Golden Colorado, 80401, United States
Rocky Mountain Cancer Centers-Lakewood
Lakewood Colorado, 80228, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
Rocky Mountain Cancer Centers-Longmont
Longmont Colorado, 80501, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
Rocky Mountain Cancer Centers-Parker
Parker Colorado, 80138, United States
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
Rocky Mountain Cancer Centers - Pueblo
Pueblo Colorado, 81008, United States
Rocky Mountain Cancer Centers-Thornton
Thornton Colorado, 80260, United States
Connecticut Children's Medical Center
Hartford Connecticut, 06106, United States
Alfred I duPont Hospital for Children
Wilmington Delaware, 19803, United States
Children's National Medical Center
Washington District of Columbia, 20010, United States
Broward Health Medical Center
Fort Lauderdale Florida, 33316, United States
Golisano Children's Hospital of Southwest Florida
Fort Myers Florida, 33908, United States
University of Florida Health Science Center - Gainesville
Gainesville Florida, 32610, United States
Nemours Children's Clinic-Jacksonville
Jacksonville Florida, 32207, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami Florida, 33136, United States
Nicklaus Children's Hospital
Miami Florida, 33155, United States
Nemours Children's Hospital
Orlando Florida, 32827, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa Florida, 33607, United States
Saint Mary's Hospital
West Palm Beach Florida, 33407, United States
Children's Healthcare of Atlanta - Egleston
Atlanta Georgia, 30322, United States
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States
Northwestern University
Chicago Illinois, 60611, United States
Rush University Medical Center
Chicago Illinois, 60612, United States
University of Chicago Comprehensive Cancer Center
Chicago Illinois, 60637, United States
Carle at The Riverfront
Danville Illinois, 61832, United States
Carle Physician Group-Effingham
Effingham Illinois, 62401, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest Illinois, 60045, United States
Carle Physician Group-Mattoon/Charleston
Mattoon Illinois, 61938, United States
Saint Jude Midwest Affiliate
Peoria Illinois, 61637, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
The Carle Foundation Hospital
Urbana Illinois, 61801, United States
Riley Hospital for Children
Indianapolis Indiana, 46202, United States
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States
Mission Cancer and Blood - West Des Moines
Clive Iowa, 50325, United States
Alegent Health Mercy Hospital
Council Bluffs Iowa, 51503, United States
Greater Regional Medical Center
Creston Iowa, 50801, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Mission Cancer and Blood - Laurel
Des Moines Iowa, 50314, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City Iowa, 52242, United States
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States
Flaget Memorial Hospital
Bardstown Kentucky, 40004, United States
Commonwealth Cancer Center-Corbin
Corbin Kentucky, 40701, United States
Saint Joseph Hospital
Lexington Kentucky, 40504, United States
Saint Joseph Radiation Oncology Resource Center
Lexington Kentucky, 40504, United States
Saint Joseph Hospital East
Lexington Kentucky, 40509, United States
Saint Joseph London
London Kentucky, 40741, United States
Jewish Hospital
Louisville Kentucky, 40202, United States
Norton Children's Hospital
Louisville Kentucky, 40202, United States
Saints Mary and Elizabeth Hospital
Louisville Kentucky, 40215, United States
UofL Health Medical Center Northeast
Louisville Kentucky, 40245, United States
Saint Joseph Mount Sterling
Mount Sterling Kentucky, 40353, United States
Jewish Hospital Medical Center South
Shepherdsville Kentucky, 40165, United States
Ochsner Medical Center Jefferson
New Orleans Louisiana, 70121, United States
Sinai Hospital of Baltimore
Baltimore Maryland, 21215, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States
Baystate Medical Center
Springfield Massachusetts, 01199, United States
C S Mott Children's Hospital
Ann Arbor Michigan, 48109, United States
Ascension Saint John Hospital
Detroit Michigan, 48236, United States
Huron Medical Center PC
Port Huron Michigan, 48060, United States
Lake Huron Medical Center
Port Huron Michigan, 48060, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Minnesota Oncology - Burnsville
Burnsville Minnesota, 55337, United States
Cambridge Medical Center
Cambridge Minnesota, 55008, United States
Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Unity Hospital
Fridley Minnesota, 55432, United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove Minnesota, 55369, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States
Saint John's Hospital - Healtheast
Maplewood Minnesota, 55109, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis Minnesota, 55404, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States
Health Partners Inc
Minneapolis Minnesota, 55454, United States
Monticello Cancer Center
Monticello Minnesota, 55362, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
Fairview Northland Medical Center
Princeton Minnesota, 55371, United States
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Regions Hospital
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States
Fairview Lakes Medical Center
Wyoming Minnesota, 55092, United States
University of Mississippi Medical Center
Jackson Mississippi, 39216, United States
Children's Mercy Hospitals and Clinics
Kansas City Missouri, 64108, United States
Cardinal Glennon Children's Medical Center
Saint Louis Missouri, 63104, United States
Washington University School of Medicine
Saint Louis Missouri, 63110, United States
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island Nebraska, 68803, United States
Heartland Hematology and Oncology
Kearney Nebraska, 68845, United States
CHI Health Good Samaritan
Kearney Nebraska, 68847, United States
Saint Elizabeth Regional Medical Center
Lincoln Nebraska, 68510, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Hematology and Oncology Consultants PC
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Midlands Community Hospital
Papillion Nebraska, 68046, United States
Carson Tahoe Regional Medical Center
Carson City Nevada, 89703, United States
Cancer and Blood Specialists-Henderson
Henderson Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada - Henderson
Henderson Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson Nevada, 89052, United States
Las Vegas Cancer Center-Henderson
Henderson Nevada, 89052, United States
OptumCare Cancer Care at Seven Hills
Henderson Nevada, 89052, United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson Nevada, 89074, United States
GenesisCare USA - Henderson
Henderson Nevada, 89074, United States
Las Vegas Urology - Green Valley
Henderson Nevada, 89074, United States
Urology Specialists of Nevada - Green Valley
Henderson Nevada, 89074, United States
Desert West Surgery
Las Vegas Nevada, 89102, United States
OptumCare Cancer Care at Charleston
Las Vegas Nevada, 89102, United States
University Medical Center of Southern Nevada
Las Vegas Nevada, 89102, United States
Hope Cancer Care of Nevada
Las Vegas Nevada, 89103, United States
Cancer and Blood Specialists-Shadow
Las Vegas Nevada, 89106, United States
Radiation Oncology Centers of Nevada Central
Las Vegas Nevada, 89106, United States
Urology Specialists of Nevada - Central
Las Vegas Nevada, 89106, United States
GenesisCare USA - Las Vegas
Las Vegas Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas Nevada, 89109, United States
Sunrise Hospital and Medical Center
Las Vegas Nevada, 89109, United States
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas Nevada, 89113, United States
Las Vegas Urology - Sunset
Las Vegas Nevada, 89113, United States
Urology Specialists of Nevada - Southwest
Las Vegas Nevada, 89113, United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas Nevada, 89119, United States
Cancer Therapy and Integrative Medicine
Las Vegas Nevada, 89121, United States
Ann M Wierman MD LTD
Las Vegas Nevada, 89128, United States
Cancer and Blood Specialists-Tenaya
Las Vegas Nevada, 89128, United States
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas Nevada, 89128, United States
GenesisCare USA - Vegas Tenaya
Las Vegas Nevada, 89128, United States
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas Nevada, 89128, United States
OptumCare Cancer Care at MountainView
Las Vegas Nevada, 89128, United States
Urology Specialists of Nevada - Northwest
Las Vegas Nevada, 89128, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas Nevada, 89135, United States
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas Nevada, 89144, United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas Nevada, 89144, United States
Summerlin Hospital Medical Center
Las Vegas Nevada, 89144, United States
Las Vegas Cancer Center-Medical Center
Las Vegas Nevada, 89148, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89148, United States
GenesisCare USA - Fort Apache
Las Vegas Nevada, 89148, United States
OptumCare Cancer Care at Fort Apache
Las Vegas Nevada, 89148, United States
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas Nevada, 89149, United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas Nevada, 89169, United States
University Cancer Center
Las Vegas Nevada, 89169, United States
Hope Cancer Care of Nevada-Pahrump
Pahrump Nevada, 89048, United States
Renown Regional Medical Center
Reno Nevada, 89502, United States
Saint Mary's Regional Medical Center
Reno Nevada, 89503, United States
Radiation Oncology Associates
Reno Nevada, 89509, United States
Cancer Care Specialists - Reno
Reno Nevada, 89511, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Albany Medical Center
Albany New York, 12208, United States
Montefiore Medical Center - Moses Campus
Bronx New York, 10467, United States
Maimonides Medical Center
Brooklyn New York, 11219, United States
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park New York, 11040, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York New York, 10032, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States
State University of New York Upstate Medical University
Syracuse New York, 13210, United States
Mission Hospital
Asheville North Carolina, 28801, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill North Carolina, 27599, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte North Carolina, 28203, United States
Children's Hospital Medical Center of Akron
Akron Ohio, 44308, United States
Good Samaritan Hospital - Cincinnati
Cincinnati Ohio, 45220, United States
Cincinnati Children's Hospital Medical Center
Cincinnati Ohio, 45229, United States
Bethesda North Hospital
Cincinnati Ohio, 45242, United States
TriHealth Cancer Institute-Westside
Cincinnati Ohio, 45247, United States
TriHealth Cancer Institute-Anderson
Cincinnati Ohio, 45255, United States
Case Western Reserve University
Cleveland Ohio, 44106, United States
Rainbow Babies and Childrens Hospital
Cleveland Ohio, 44106, United States
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States
Nationwide Children's Hospital
Columbus Ohio, 43205, United States
Dayton Children's Hospital
Dayton Ohio, 45404, United States
ProMedica Flower Hospital
Sylvania Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States
Cancer Treatment Centers of America
Tulsa Oklahoma, 74133, United States
Legacy Emanuel Children's Hospital
Portland Oregon, 97227, United States
Oregon Health and Science University
Portland Oregon, 97239, United States
Children's Hospital of Philadelphia
Philadelphia Pennsylvania, 19104, United States
Fox Chase Cancer Center
Philadelphia Pennsylvania, 19111, United States
Children's Hospital of Pittsburgh of UPMC
Pittsburgh Pennsylvania, 15224, United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs South Carolina, 29316, United States
Medical University of South Carolina
Charleston South Carolina, 29425, United States
Prisma Health Cancer Institute - Laurens
Clinton South Carolina, 29325, United States
Prisma Health Cancer Institute - Easley
Easley South Carolina, 29640, United States
Prisma Health Cancer Institute - Butternut
Greenville South Carolina, 29605, United States
Prisma Health Cancer Institute - Faris
Greenville South Carolina, 29605, United States
Prisma Health Cancer Institute - Eastside
Greenville South Carolina, 29615, United States
Prisma Health Cancer Institute - Greer
Greer South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca
Seneca South Carolina, 29672, United States
Memorial Hospital
Chattanooga Tennessee, 37404, United States
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson Tennessee, 37343, United States
East Tennessee Childrens Hospital
Knoxville Tennessee, 37916, United States
Saint Jude Children's Research Hospital
Memphis Tennessee, 38105, United States
The Children's Hospital at TriStar Centennial
Nashville Tennessee, 37203, United States
Memorial GYN Plus
Ooltewah Tennessee, 37363, United States
Dell Children's Medical Center of Central Texas
Austin Texas, 78723, United States
Saint Joseph Regional Cancer Center
Bryan Texas, 77802, United States
El Paso Children's Hospital
El Paso Texas, 79905, United States
Cook Children's Medical Center
Fort Worth Texas, 76104, United States
M D Anderson Cancer Center
Houston Texas, 77030, United States
Children's Hospital of San Antonio
San Antonio Texas, 78207, United States
Methodist Children's Hospital of South Texas
San Antonio Texas, 78229, United States
University Hospital
San Antonio Texas, 78229, United States
University of Texas Health Science Center at San Antonio
San Antonio Texas, 78229, United States
Primary Children's Hospital
Salt Lake City Utah, 84113, United States
University of Virginia Cancer Center
Charlottesville Virginia, 22908, United States
Children's Hospital of The King's Daughters
Norfolk Virginia, 23507, United States
Overlake Medical Center
Bellevue Washington, 98004, United States
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton Washington, 98310, United States
Highline Medical Center-Main Campus
Burien Washington, 98166, United States
Saint Elizabeth Hospital
Enumclaw Washington, 98022, United States
Saint Francis Hospital
Federal Way Washington, 98003, United States
Saint Clare Hospital
Lakewood Washington, 98499, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo Washington, 98370, United States
Seattle Children's Hospital
Seattle Washington, 98105, United States
Saint Michael Cancer Center
Silverdale Washington, 98383, United States
Providence Sacred Heart Medical Center and Children's Hospital
Spokane Washington, 99204, United States
Franciscan Research Center-Northwest Medical Plaza
Tacoma Washington, 98405, United States
Mary Bridge Children's Hospital and Health Center
Tacoma Washington, 98405, United States
Northwest Medical Specialties PLLC
Tacoma Washington, 98405, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima Washington, 98902, United States
West Virginia University Charleston Division
Charleston West Virginia, 25304, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay Wisconsin, 54303, United States
Holy Family Memorial Hospital
Manitowoc Wisconsin, 54221, United States
Saint Vincent Hospital Cancer Center at Marinette
Marinette Wisconsin, 54143, United States
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States
Children's Hospital of Wisconsin
Milwaukee Wisconsin, 53226, United States
Cancer Center of Western Wisconsin
New Richmond Wisconsin, 54017, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls Wisconsin, 54154, United States
HSHS Saint Nicholas Hospital
Sheboygan Wisconsin, 53081, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay Wisconsin, 54235, United States
HIMA San Pablo Oncologic Hospital
Caguas , 00726, Puerto Rico

How clear is this clinincal trial information?

Study is for people with:

Kidney Cancer

Phase:

Phase 2

Estimated Enrollment:

40

Study ID:

NCT03595124

Recruitment Status:

Active, not recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

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