Study Of AG-013736 In Patients With Refractory Metastatic Renal Cell Cancer

Inclusion Criteria:

RCC with metastases and nephrectomy
failure of prior sorafenib-based therapy
at least 1 target lesion that has not been irradiated
adequate bone marrow, hepatic and renal function, > or equal to 18 years of age.

Exclusion Criteria:

Gastrointestinal abnormalities
current use or inability to avoid chronic antacid therapy
current use or anticipated inability to avoid potent CYP3A4 inhibitors or CYP1A2 inducers
active seizure disorder or evidence of brain metastases.