Lung Cancer Clinical Trial
A Global Study to Assess the Effects of MEDI4736 Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer
Summary
A Global Study to Assess the Effects of MEDI4736 following concurrent chemoradiation in Patients with Stage III Unresectable Non-Small Cell Lung Cancer.
Full Description
A Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of MEDI4736 as Sequential Therapy in Patients with Locally Advanced, Unresectable Non-Small Cell Lung Cancer (Stage III) Who Have Not Progressed Following Definitive, Platinum-based, Concurrent Chemoradiation Therapy (PACIFIC)
Eligibility Criteria
Inclusion Criteria:
Age at least 18 years.
Documented evidence of NSCLC (locally advanced, unresectable, Stage III)
Patients must have received at least 2 cycles of platinum-based chemotherapy concurrent with radiation therapy.
World Health Organisation (WHO) Performance Status of 0 to 1.
Estimated life expectancy of more than 12 weeks.
Exclusion Criteria:
Prior exposure to any anti-PD-1 or anti-PD-L1 antibody.
Active or prior autoimmune disease or history of immunodeficiency.
Evidence of severe or uncontrolled systemic diseases, including active bleeding diatheses or active infections including hepatitis B, C and HIV.
Evidence of uncontrolled illness such as symptomatic congestive heart failure, uncontrolled hypertension or unstable angina pectoris.
Any unresolved toxicity CTCAE >Grade 2 from the prior chemoradiation therapy.
Active or prior documented inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis).
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There are 232 Locations for this study
Chandler Arizona, 85224, United States
Goodyear Arizona, 85338, United States
Jonesboro Arkansas, 72405, United States
Springdale Arkansas, 72762, United States
Fullerton California, 92835, United States
Los Angeles California, 90095, United States
Oxnard California, 93030, United States
Sacramento California, 95816, United States
San Diego California, 92123, United States
Santa Rosa California, 95403, United States
Norwich Connecticut, 06360, United States
Washington District of Columbia, 20007, United States
Fort Myers Florida, 33901, United States
Jacksonville Florida, 32207, United States
Miami Beach Florida, 33140, United States
Orlando Florida, 32804, United States
Port Saint Lucie Florida, 34952, United States
Saint Petersburg Florida, 33705, United States
Tampa Florida, 33612, United States
Atlanta Georgia, 30318, United States
Atlanta Georgia, 30322, United States
Fort Gordon Georgia, 30905, United States
Lawrenceville Georgia, 30046, United States
Marietta Georgia, 30060, United States
Waterloo Iowa, 50701, United States
Topeka Kansas, 66606, United States
Hazard Kentucky, 41701, United States
Baltimore Maryland, 21287, United States
Rockville Maryland, 20850, United States
Rosedale Maryland, 21237, United States
Salisbury Maryland, 21801, United States
Towson Maryland, 21204, United States
Boston Massachusetts, 02215, United States
Lansing Michigan, 48910, United States
Minneapolis Minnesota, 55426, United States
Saint Louis Missouri, 63110, United States
Lincoln Nebraska, 68510, United States
Hackensack New Jersey, 07601, United States
Bronx New York, 10461, United States
Lake Success New York, 11041, United States
Burlington North Carolina, 27215, United States
Charlotte North Carolina, 28204, United States
Pinehurst North Carolina, 28374, United States
Winston-Salem North Carolina, 27103, United States
Blue Ash Ohio, 45242, United States
Easley South Carolina, 29640, United States
Chattanooga Tennessee, 37404, United States
Nashville Tennessee, 37203, United States
Nashville Tennessee, 37232, United States
Austin Texas, 78731, United States
Dallas Texas, 75231, United States
Dallas Texas, 75246, United States
Fort Worth Texas, 76104, United States
Houston Texas, 77030, United States
Tyler Texas, 75702, United States
Salt Lake City Utah, 84106, United States
Fairfax Virginia, 22031, United States
Spokane Washington, 99208, United States
Spokane Washington, 99218, United States
Vancouver Washington, 98684, United States
Bedford Park , 5042, Australia
Bendigo , 3550, Australia
Box Hill , 3128, Australia
Clayton , 3168, Australia
Heidelberg , 3084, Australia
Herston , 4029, Australia
Kogarah , 2217, Australia
Launceston , 7250, Australia
Nedlands , 6009, Australia
Port Macquarie , 2444, Australia
Randwick , 2031, Australia
Westmead , 2145, Australia
Woolloongabba , 4102, Australia
Aalst , 9300, Belgium
Gilly , 6060, Belgium
Leuven , 3000, Belgium
Libramont-Chevigny , 6800, Belgium
Liège , 4000, Belgium
Calgary Alberta, T2N 4, Canada
Edmonton Alberta, T6G 1, Canada
Vancouver British Columbia, V5Z 4, Canada
Barrie Ontario, L4M 6, Canada
London Ontario, N6A 4, Canada
Newmarket Ontario, L3Y 2, Canada
Oshawa Ontario, L1G 2, Canada
Toronto Ontario, M4N 3, Canada
Toronto , M5G 2, Canada
Santiago , 75000, Chile
Santiago , 84203, Chile
Viña del Mar , , Chile
Avignon Cedex 9 , 84918, France
Bayonne , 64100, France
Brest Cedex , 29609, France
Lille , 59037, France
Lyon , 69008, France
Marseille Cedex 20 , 13915, France
Montpellier Cedex , 34295, France
Nantes , 44202, France
Nice , 06100, France
Pau cedex , 6400, France
Rennes , 35033, France
Saint Herblain , 44805, France
Toulouse , 31000, France
Villejuif Cedex , 94805, France
Berlin , 10967, Germany
Berlin , 12351, Germany
Esslingen , 73730, Germany
Grosshansdorf , 20927, Germany
Hamburg , 20251, Germany
Hamburg , 22081, Germany
Löwenstein , 74245, Germany
Recklinghausen , 45659, Germany
Regensburg , 93053, Germany
Villingen-Schwenningen , 78052, Germany
Athens , 11527, Greece
Heraklion , 71110, Greece
Patras , 26500, Greece
Thessaloniki , 54645, Greece
Thessaloniki , 57010, Greece
Budapest , 1083, Hungary
Budapest , 1121, Hungary
Gyula , 5703, Hungary
Miskolc , 3529, Hungary
Haifa , 31096, Israel
Jerusalem , 91120, Israel
Aviano , 33081, Italy
Catania , 95123, Italy
Cremona , 26100, Italy
Lecce , 73100, Italy
Milano , 20132, Italy
Milano , 20133, Italy
Napoli , 80138, Italy
Pisa , 56126, Italy
Roma , 00144, Italy
Bunkyo-ku , 113-8, Japan
Bunkyo-ku , 113-8, Japan
Chuo-ku , 104-0, Japan
Fukuoka , 812-8, Japan
Habikino-shi , 583-8, Japan
Hidaka-shi , 350-1, Japan
Hirakata-shi , 573-1, Japan
Hiroshima-shi , 730-8, Japan
Kanazawa , 920-8, Japan
Kashiwa , 277-8, Japan
Kitaadachi-gun , 362-0, Japan
Kurume-shi , 830-0, Japan
Matsuyama-shi , 791-0, Japan
Nagoya-shi , 460-0, Japan
Natori-shi , 981-1, Japan
Okayama-shi , 700-8, Japan
Osaka-shi , 541-8, Japan
Osakasayama , 589-8, Japan
Ota-shi , 373-8, Japan
Sagamihara-shi , 252-0, Japan
Sakai-shi , 591-8, Japan
Sapporo-shi , 003-0, Japan
Sendai-shi , 980-0, Japan
Shinjuku-ku , 162-8, Japan
Sunto-gun , 411-8, Japan
Takatsuki-shi , 569-8, Japan
Ube-shi , 755-0, Japan
Yokohama-shi , 236-0, Japan
Yokohama-shi , 241-8, Japan
Busan , 49201, Korea, Republic of
Cheongju-si , 361-7, Korea, Republic of
Hwasun-gun , 58128, Korea, Republic of
Incheon , UNK, Korea, Republic of
Seongnam-si , 13620, Korea, Republic of
Seoul , 02841, Korea, Republic of
Seoul , 03722, Korea, Republic of
Seoul , 05505, Korea, Republic of
Seoul , 06351, Korea, Republic of
Suwon , 16247, Korea, Republic of
Cuautitlan Izcalli , 54769, Mexico
Monterrey , 64460, Mexico
Oaxaca , 68000, Mexico
Orizaba , 94300, Mexico
Amsterdam , 1066 , Netherlands
Amsterdam , 1081 , Netherlands
Breda , 4818 , Netherlands
Eindhoven , 5623E, Netherlands
Rotterdam , 3015 , Netherlands
Tilburg , 5022 , Netherlands
Lima , 41, Peru
Lima , LIMA , Peru
Gdansk , 80-95, Poland
Lublin , 20-36, Poland
Warszawa , 02-78, Poland
Singapore , 11907, Singapore
Singapore , 16961, Singapore
Singapore , 30843, Singapore
Bardejov , 08501, Slovakia
Kosice , 041 9, Slovakia
Nove Zamky , 94002, Slovakia
Trnava , 91775, Slovakia
Cape Town , 7570, South Africa
Pretoria , 0181, South Africa
Vereeniging , 1930, South Africa
Alicante , 03010, Spain
Barcelona , 08003, Spain
Barcelona , 08041, Spain
Barcelona , 08908, Spain
Gerona , 17007, Spain
Lérida , 25198, Spain
Madrid , 28005, Spain
Madrid , 28007, Spain
Madrid , 28041, Spain
Madrid , 28046, Spain
Madrid , 28050, Spain
San Sebastian , 20014, Spain
Sevilla , 41009, Spain
Sevilla , 41013, Spain
Valencia , 46014, Spain
Valencia , 46026, Spain
Zaragoza , 50009, Spain
Taichung , 40447, Taiwan
Taipei City , 110, Taiwan
Taipei , 112, Taiwan
Taipei , 23561, Taiwan
Taipei , , Taiwan
Bangkok , 10400, Thailand
Hat Yai , 90110, Thailand
Muang , 50200, Thailand
Adana , 01130, Turkey
Ankara , 06490, Turkey
Istanbul , 34030, Turkey
Istanbul , 34844, Turkey
Izmir , 35100, Turkey
Konya , 42080, Turkey
Malatya , 44280, Turkey
Glasgow , G12 0, United Kingdom
Manchester , M20 4, United Kingdom
Truro , TR1 3, United Kingdom
Hanoi , 10000, Vietnam
Hanoi , 10000, Vietnam
Ho Chi Minh , 70000, Vietnam
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