Lung Cancer Clinical Trial
A Study of Nivolumab and Ipilimumab in Untreated Participants With Stage 3 Non-small Cell Lung Cancer (NSCLC) That is Unable or Not Planned to be Removed by Surgery
Summary
The primary purpose of the study is to compare the effectiveness of nivolumab plus concurrent chemoradiotherapy (CCRT) followed by nivolumab plus ipilimumab vs CCRT followed by durvalumab in participants with untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC).
Eligibility Criteria
Inclusion Criteria:
Eastern Cooperative Oncology Group (ECOG) performance status ≤1
Locally advanced stage IIIA, IIIB, or IIIC (T1-2 N2-3 M0, T3 N1-3 M0, or T4 N0-3 M0) pathologically-confirmed NSCLC, according to 8th TNM classification. Participants who are not planned for potential curative surgical resection are eligible.
Newly diagnosed and treatment-naïve, with no prior local or systemic anticancer therapy given as primary therapy for locally advanced disease
Exclusion Criteria:
Any condition including medical, emotional, psychiatric, or logistical that, in the opinion of the Investigator would preclude the participant from adhering to the protocol or would increase the risk associated with study participation
Active infection requiring systemic therapy within 14 days prior to randomization
History of organ or tissue transplant that requires systemic use of immune suppressive agents
Prior thoracic radiotherapy
Other protocol-defined inclusion/exclusion criteria apply
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There are 178 Locations for this study
La Jolla California, 92093, United States
San Francisco California, 94115, United States
San Francisco California, 94143, United States
Lone Tree Colorado, 80124, United States
Jacksonville Florida, 32207, United States
Orlando Florida, 32804, United States
Pensacola Florida, 32504, United States
Atlanta Georgia, 30322, United States
Augusta Georgia, 30912, United States
Edgewood Kentucky, 41017, United States
Bethesda Maryland, 20817, United States
Traverse City Michigan, 49684, United States
Cincinnati Ohio, 45220, United States
Cincinnati Ohio, 45236, United States
Cincinnati Ohio, 45267, United States
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44109, United States
Youngstown Ohio, 44501, United States
Charleston South Carolina, 29414, United States
Austin Texas, 78731, United States
Bryan Texas, 77802, United States
Dallas Texas, 75203, United States
Burlington Vermont, 05405, United States
Caba Buenos Aires, C1426, Argentina
Río Cuarto Cordoba, 5800, Argentina
Buenos Aires Distrito Federal, C1199, Argentina
Caba Distrito Federal, 1430, Argentina
Darlinghurst New South Wales, 2010, Australia
Gosford New South Wales, 2250, Australia
Kingswood New South Wales, 2747, Australia
Greenslopes Queensland, 4120, Australia
Adelaide South Australia, 5000, Australia
Ballarat Central Victoria, 3350, Australia
Melbourne Victoria, 3004, Australia
Melbourne Victoria, 3199, Australia
Murdoch Western Australia, 6150, Australia
Bruxelles , 1200, Belgium
Gent , 9000, Belgium
Liege , 4000, Belgium
Yvoir , B-553, Belgium
Ipatinga Minas Gerais, 35160, Brazil
Ijui RIO Grande DO SUL, 98700, Brazil
Porto Alegre RIO Grande DO SUL, 91350, Brazil
Blumenau Santa Catarina, 89010, Brazil
Barretos SAO Paulo, 14784, Brazil
Rio de Janeiro , 20230, Brazil
Kingston Ontario, K7L 2, Canada
Oshawa Ontario, L1G 2, Canada
Chicoutimi Quebec, G7H 5, Canada
Rimouski Quebec, G5L 5, Canada
Trois-Rivieres Quebec, G8Z 3, Canada
Quebec , G1V 4, Canada
Santiago Metropolitana, 84203, Chile
Vina del Mar Valparaiso, 25205, Chile
Beijing BEI, 10014, China
Chongqing Chongqing, 40003, China
Fuzhou Fujian, 35000, China
Xiamen Fujian, 36100, China
Guiyang Guizhou, 55000, China
Hankou Hubei, 43002, China
Wuhan Hubei, 21000, China
Wuhan Hubei, 43006, China
Changsha Hunan, 41001, China
Nanjing Jiangsu, 21000, China
Nanchang Jiangxi, 33000, China
Changchun Jilin, 13001, China
Changchun Jilin, 13002, China
Gongzhuling Jilin, 13200, China
Jinan Shandong, 25011, China
Shanghai Shanghai, 20044, China
Chengdu Sichuan, 61004, China
Chengdu Sichuan, 61004, China
Hangzhou Zhejiang, 31000, China
Linhai Zhejiang, 31700, China
Bordeaux , 33076, France
Dijon , 21000, France
Lyon , 69008, France
Montpellier , 34070, France
Nantes , 44000, France
Paris Cedex 14 , 75679, France
Paris Cedex 5 , 75248, France
Paris , 75018, France
Paris , 75020, France
Tours Cedex 09 , 37044, France
Berlin , 14165, Germany
Essen , 45136, Germany
Grosshansdorf , 22927, Germany
Hamm , 59063, Germany
Heidelberg , 69126, Germany
Immenhausen , 34376, Germany
Kempten , 87439, Germany
Loewenstein , 74245, Germany
Mainz , 55131, Germany
Stuttgart , 70376, Germany
Athens , 115 2, Greece
Athens , 11527, Greece
Larissa , 41110, Greece
N.Kifissia , 14564, Greece
Dublin 8 Dublin, , Ireland
Dublin , 00004, Ireland
Brescia , 25123, Italy
Catania , 95100, Italy
Catanzaro , 88100, Italy
Lucca , 55100, Italy
Milano , 20141, Italy
Monza , 20900, Italy
Perugia , 06129, Italy
Nagoya Aichi, 46486, Japan
Fukuoka-shi Fukuoka, 81285, Japan
Kurume-shi Fukuoka, 83000, Japan
Ota Gunma, 373-8, Japan
Sapporo-shi Hokkaido, 00308, Japan
Kobe Hyogo, 65000, Japan
Kanazawa-shi Ishikawa, 92086, Japan
Yokohama-shi Kanagawa, 22108, Japan
Yokohama-Shi Kanagawa, 23600, Japan
Yokohama Kanagawa, 24185, Japan
Sendai-shi Miyagi, 98008, Japan
Niigata-shi Niigata, 95185, Japan
Osaka-shi Osaka, 54585, Japan
Osakasayama Osaka, 589-8, Japan
Hidaka-shi Saitama, 35012, Japan
Kitaadachi-gun Saitama, 36208, Japan
Bunkyo-ku Tokyo, 11386, Japan
Chuo-ku Tokyo, 10400, Japan
Wakayama-shi Wakayama, 641-8, Japan
Ube Yamaguchi, 755-0, Japan
Cheongju-si, Chungcheonbuk-do, , 361-7, Korea, Republic of
Seoul , 03722, Korea, Republic of
Seoul , 06351, Korea, Republic of
La Paz BAJA Californa SUR, 23040, Mexico
Df Distrito Federal, 06720, Mexico
Guadalajara Jalisco, 44340, Mexico
Monterrey Nuevo LEON, 64060, Mexico
Culiacan Sinaloa, 80230, Mexico
Amsterdam , 1081H, Netherlands
Arnhem , 6815 , Netherlands
Leiden , 2333Z, Netherlands
Maastrict , 6229 , Netherlands
Veldhoven , 5504 , Netherlands
Bydgoszcz , 85796, Poland
Gdansk , 80-21, Poland
Krakow , 31-82, Poland
Tomaszow Mazowiecki , 97-20, Poland
Hato Rey , 00917, Puerto Rico
San Juan , 917, Puerto Rico
Bucharest , 02232, Romania
Bucuresti , 02254, Romania
Cluj-Napoca , 40001, Romania
Constanta , 90059, Romania
Craiova , 20054, Romania
Floresti/ Cluj , 40728, Romania
Moscow , 10522, Russian Federation
Moscow , 11547, Russian Federation
Moscow , 12536, Russian Federation
St. Petersburg , 19775, Russian Federation
Singapore , 16858, Singapore
Barcelona , 8025, Spain
Hospitalet de Llobregat , 08907, Spain
Madrid , 28007, Spain
Madrid , 28046, Spain
Pamplona , 31008, Spain
Santiago de Compostela , 15706, Spain
Sevilla , 41013, Spain
Zaragoza , 50009, Spain
Goteborg Vastra Gotalands Lan, 41345, Sweden
Stockholm , 171 7, Sweden
Basel , 4031, Switzerland
Lausanne , 1011, Switzerland
St.Gallen , 9007, Switzerland
Zuerich , 8091, Switzerland
KaohsiungCity , 83301, Taiwan
New Taipei City , 235, Taiwan
Tainan , 704, Taiwan
Taipei City , 100, Taiwan
Taipei , 10099, Taiwan
Taipei , 112, Taiwan
Poole Dorset, BH15 , United Kingdom
Swansea Glamorgan, SA2 8, United Kingdom
Aberdeen , AB25 , United Kingdom
Bebington , CH63 , United Kingdom
Hull , HU16 , United Kingdom
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