To compare the difference of a marker of cellular proliferation in all bronchial biopsy specimens of former smokers stratified by lung cancer risk, collected before and after treatment per patient between the enzastaurin and placebo groups.
Sputum atypia participants with normal sputum cytology will be removed from the study) Metaplasia or dysplasia on at least one bronchoscopy specimen History of cigarette smoking ≥30 Pack Years Quit smoking ≥1 year prior to study entry Able to undergo bronchoscopy and helical computed tomography (CT) scanning of the chest Able to swallow tablets
Exclusion Criteria:
Blood clotting abnormalities Current smoking within the past 1 year Unwillingness to abstain from smoking while enrolled in the clinical trial or unwillingness to avoid significant second hand smoke exposure Evidence for lung cancer or carcinoma in situ Active cardiovascular disease Current illicit drug or alcohol abuse
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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Tampa Florida, 33612, United States
