Lung Cancer Clinical Trial

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Adjuvant Cisplatin and Docetaxel in Non Small Cell Lung Cancer

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Summary

To determine if docetaxel and cisplatin can be administered in a dose intense manner in the adjuvant setting in resected non-small cell lung cancer
To evaluate the time to progression and overall survival
To evaluate toxicities of this chemotherapy combination in the adjuvant setting
To correlate XPD and ERCC1 polymorphisms with time to progression and toxicities in patients treated with this regimen

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Eligibility Criteria

Inclusion Criteria:

Stage IB to IIIA non-small cell lung cancer completely resected within 4 to 8 weeks of initiating treatment on study
Performance Status ECOG 0 or 1
Peripheral neuropathy: < grade 1
Adequate blood cell counts
Adequate liver and hepatic function
Women of childbearing potential must have a negative pregnancy test.
Men and women of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 3 months thereafter

Exclusion Criteria:

Patients with a history of severe hypersensitivity reaction to Docetaxel® or other drugs formulated with polysorbate 80.
Women who are breast-feeding.
Coexistent second malignancy or history of prior malignancy within previous 5 years (excluding basal or squamous cell carcinoma of the skin that has been treated curatively)
Uncontrolled cardiac disease or uncontrolled hypertension

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

4

Study ID:

NCT00582634

Recruitment Status:

Completed

Sponsor:

University of Wisconsin, Madison

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There is 1 Location for this study

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University of Wisconsin Comprehensive Cancer Center
Madison Wisconsin, 53792, United States

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Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

4

Study ID:

NCT00582634

Recruitment Status:

Completed

Sponsor:


University of Wisconsin, Madison

How clear is this clinincal trial information?

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