Lung Cancer Clinical Trial

Clinical Trial Finder Lung Cancer Trials

An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors

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Summary

Patients are asked to participate in this study if they have been diagnosed with a thoracic carcinoma which includes lung cancer and have a gene mutation (alteration in the body's genetic instructions) and after undergoing treatment the cancer has come back, progressed, or shown a partial response on standard treatment.

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Full Description

In order to improve the treatment outcome for thoracic carcinomas after they become resistant to targeted therapy, the investigator is using tumor biopsies at the time of recurrence for genomic analysis to identify novel somatic changes in critical genes and gene pathways that can potentially be targeted with therapy. The study team is also creating patient-derived xenografts to test drug efficacy and optimize personalized therapy for each patient.

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Eligibility Criteria

Inclusion Criteria:

18 years or older
Thoracic carcinoma tumors are positive for any targetable genetic alterations
Have shown partial or no response, progression or recurrence while on or after gene targeted therapy by CT/PET scan
Tumor is accessible for biopsy or surgery
Expected life is 6 months or longer.

Exclusion Criteria:

< 18 years
Not able to communicate in English

Study is for people with:

Lung Cancer

Estimated Enrollment:

15

Study ID:

NCT02616211

Recruitment Status:

Completed

Sponsor:

Mayo Clinic

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There is 1 Location for this study

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Mayo Clinic in Rochester
Rochester Minnesota, 55905, United States

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Study is for people with:

Lung Cancer

Estimated Enrollment:

15

Study ID:

NCT02616211

Recruitment Status:

Completed

Sponsor:


Mayo Clinic

How clear is this clinincal trial information?

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