Lung Cancer Clinical Trial

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An Open-Label, Randomized, Phase 3 Trial of Nivolumab Versus Investigator’s Choice Chemotherapy as First-Line Therapy for Stage IV or Recurrent PD-L1+ Non-Small Cell Lung Cancer (CheckMate 026)

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Summary

The purpose of this study is to show that Nivolumab will improve progression free survival in subjects with strongly Stage IV or Recurrent PD-L1+ non-small cell lung cancer when compared to chemotherapy

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 1
Histologically confirmed Stage IV, or Recurrent NSCLC with no prior systemic anticancer therapy
Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) per response evaluation criteria in solid tumors version (RECIST) 1.1 criteria
PD-L1+ on immunohistochemistry testing performed by central lab
Men and women, ages ≥ 18 years of age

Exclusion Criteria:

Known epidermal growth factor receptor (EGFR) mutations which are sensitive to available targeted inhibitor therapy
Known anaplastic lymphoma kinase (ALK) translocations
Untreated central nervous system (CNS) metastases
Previous malignancies
Active, known or suspected autoimmune disease

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

541

Study ID:

NCT02041533

Recruitment Status:

Completed

Sponsor:

Bristol-Myers Squibb

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There are 139 Locations for this study

See Locations Near You

Southern Cancer Center, Inc.
Mobile Alabama, 36608, United States
Banner MD Anderson Cancer Center
Gilbert Arizona, 85234, United States
Local Institution - 0034
Tucson Arizona, 85704, United States
Local Institution - 0016
Stanford California, 94305, United States
University Of Colorado Hosp
Aurora Colorado, 80045, United States
Local Institution - 0020
New Haven Connecticut, 06520, United States
Local Institution - 0030
Miami Florida, 33176, United States
Local Institution - 0033
Ocala Florida, 34471, United States
H. Lee Moffitt Cancer Center
Tampa Florida, 33612, United States
Local Institution - 0010
Atlanta Georgia, 30322, United States
Northwest Georgia Oncology Center, P.C.
Marietta Georgia, 30060, United States
Local Institution - 0037
Chicago Illinois, 60612, United States
Local Institution - 0014
Lexington Kentucky, 40503, United States
Crescent City Research Consortium, LLC
Marrero Louisiana, 70072, United States
Local Institution - 0024
Baltimore Maryland, 21287, United States
Local Institution - 0036
Boston Massachusetts, 02114, United States
Local Institution - 0070
Boston Massachusetts, 02215, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
Local Institution - 0009
New York New York, 10016, United States
Local Institution - 0005
New York New York, 10065, United States
University Of North Carolina At Chapel Hill
Chapel Hill North Carolina, 27599, United States
Local Institution - 0003
Durham North Carolina, 27710, United States
Local Institution - 0012
Cleveland Ohio, 44106, United States
Local Institution - 0027
Columbus Ohio, 43210, United States
Oregon Health & Science University
Portland Oregon, 97239, United States
Local Institution - 0007
Allentown Pennsylvania, 18103, United States
Local Institution - 0054
Philadelphia Pennsylvania, 19104, United States
Local Institution - 0002
Philadelphia Pennsylvania, 19111, United States
Local Institution - 0018
Pittsburgh Pennsylvania, 15232, United States
Local Institution - 0011
Charleston South Carolina, 29425, United States
Local Institution - 0038
Greenville South Carolina, 29601, United States
Local Institution - 0008
Nashville Tennessee, 37232, United States
Local Institution - 0006
Dallas Texas, 75390, United States
Local Institution - 0023
Houston Texas, 77030, United States
Cancer Centers of South Texas
San Antonio Texas, 78212, United States
Local Institution - 0029
Yakima Washington, 98902, United States
Local Institution - 0051
Berazategui Buenos Aires, 1880, Argentina
Local Institution - 0049
Capital Federal Buenos Aires, 1426, Argentina
Local Institution - 0052
Ciudad Autonoma De Buenos Aire Buenos Aires, 1181, Argentina
Local Institution - 0048
Cordoba , 5000, Argentina
Local Institution - 0050
Cordoba , 5000, Argentina
Local Institution - 0090
Camperdown New South Wales, 2050, Australia
Local Institution - 0091
Brisbane Queensland, 4102, Australia
Local Institution - 0071
Elizabeth Vale South Australia, 5112, Australia
Local Institution - 0072
Fitzroy Victoria, 3065, Australia
Local Institution - 0104
Heidelberg Victoria, 3084, Australia
Local Institution - 0088
Wels , 4600, Austria
Local Institution - 0087
Wien , 1090, Austria
Local Institution - 0044
Brussels , 1090, Belgium
Local Institution - 0055
Edegem , 2650, Belgium
Local Institution - 0056
Gent , 9000, Belgium
Local Institution - 0062
Leuven , 3000, Belgium
Local Institution - 0134
Ijui Rio Grande Do Sul, 98700, Brazil
Local Institution - 0133
Porto Alegre Rio Grande Do Sul, 90610, Brazil
Local Institution - 0135
Barretos Sao Paulo, 14780, Brazil
Local Institution - 0086
Calgary Alberta, T2N 4, Canada
Local Institution - 0115
Hamilton Ontario, L8V 5, Canada
Local Institution - 0113
Toronto Ontario, M5G 2, Canada
Local Institution - 0110
Montreal Quebec, H2X 3, Canada
Local Institution - 0109
Rimouski Quebec, G5L 5, Canada
Local Institution - 0059
Olomouc , 779 0, Czechia
Local Institution - 0061
Ostrava - Poruba , 708 5, Czechia
Local Institution - 0058
Praha 8 , 180 8, Czechia
Local Institution - 0060
Usti nad Labem , 401 1, Czechia
Local Institution - 0120
Helsinki , 00029, Finland
Local Institution - 0119
Tampere , 33521, Finland
Local Institution - 0118
Vaasa , 65130, Finland
Local Institution - 0123
Caen , 14000, France
Local Institution - 0105
Lille , 59000, France
Local Institution - 0102
Marseille Cedex 20 , 13915, France
Local Institution - 0167
Pontoise Cedex , 95303, France
Local Institution - 0100
Rennes Cedex 9 , 35033, France
Local Institution - 0140
Strasbourg , 67090, France
Local Institution - 0074
Bamberg , 96049, Germany
Local Institution - 0065
Grosshansdorf , 22927, Germany
Local Institution - 0064
Heidelberg , 69126, Germany
Local Institution - 0063
Koeln , 50937, Germany
Local Institution - 0066
Stuttgart , 70376, Germany
Local Institution - 0092
Wiesbaden , 65199, Germany
Local Institution - 0073
Heraklion Creta, 71110, Greece
Local Institution - 0075
Athens , 11527, Greece
Local Institution - 0126
Budapest , 1121, Hungary
Local Institution - 0116
Debrecen , 4032, Hungary
Local Institution - 0094
Matrahaza , 3233, Hungary
Local Institution - 0084
Avellino , 83100, Italy
Local Institution - 0079
Livorno , 57100, Italy
Local Institution - 0143
Milano , 20141, Italy
Local Institution - 0142
Napoli , 80131, Italy
Local Institution - 0083
Perugia , 06132, Italy
Local Institution - 0082
Terni , 05100, Italy
Local Institution - 0161
Nagoya-shi Aichi, 46400, Japan
Local Institution - 0146
Nagoya Aichi, 46000, Japan
Local Institution - 0148
Matsuyama-shi Ehime, 79102, Japan
Local Institution - 0153
Kobe City Hyogo, 65000, Japan
Local Institution - 0144
Natori-shi Miyagi, 98112, Japan
Local Institution - 0151
Niigata-shi Niigata, 951-8, Japan
Local Institution - 0166
Habikino-shi Osaka, 56385, Japan
Local Institution - 0147
Miyakojima-ku Osaka, 534-0, Japan
Local Institution - 0145
Osaka-sayama Osaka, 589-8, Japan
Local Institution - 0152
Sakai Osaka, 591-8, Japan
Local Institution - 0150
Kitaadachi-gun Saitama, 36208, Japan
Local Institution - 0149
Sunto-gun Shizuoka, 41187, Japan
Local Institution - 0154
Chuo-ku Tokyo, 10400, Japan
Local Institution - 0159
Akashi, Hyogo , 673-8, Japan
Local Institution - 0162
Ota, Gunma , 37385, Japan
Local Institution - 0165
Sapporo, Hokkaido , 062-0, Japan
Local Institution - 0160
Tokyo , 13585, Japan
Local Institution - 0158
Wakayama , 641-8, Japan
Local Institution - 0155
Gangnam-gu , 06351, Korea, Republic of
Local Institution - 0164
Seoul , 03722, Korea, Republic of
Local Institution - 0163
Seoul , 0, Korea, Republic of
Local Institution - 0117
Mexico Distrito Federal, 14080, Mexico
Local Institution - 0122
Guadalajara Jalisco, 44280, Mexico
Local Institution - 0124
Merida Yucatan, 97133, Mexico
Local Institution - 0045
Amsterdam , 1066 , Netherlands
Local Institution - 0057
Groningen , 9700R, Netherlands
Local Institution - 0046
Rotterdam , 3014 , Netherlands
Local Institution - 0114
Bydgoszcz , 85-79, Poland
Local Institution - 0131
Krakow , 31-20, Poland
Local Institution - 0139
Lodz , 93-51, Poland
Local Institution - 0089
Warszawa , 02-78, Poland
Local Institution - 0093
Wodzislaw Slaski , 44-30, Poland
Local Institution - 0068
Cluj Napoca , 40001, Romania
Local Institution - 0067
Cluj-napoca , 40035, Romania
Local Institution - 0069
Ploiesti , 10033, Romania
Local Institution - 0040
Barcelona , 08035, Spain
Local Institution - 0041
Las Palmas De Gran Canaria , 35016, Spain
Local Institution - 0047
Madrid , 28050, Spain
Local Institution - 0042
Malaga , 29010, Spain
Local Institution - 0039
Sevilla , 41013, Spain
Local Institution - 0043
Valencia , 46014, Spain
Local Institution - 0127
Stockholm , 171 7, Sweden
Local Institution - 0125
Uppsala , 751 8, Sweden
Local Institution - 0076
Chur , 7000, Switzerland
Local Institution - 0077
Lausanne , 1011, Switzerland
Local Institution - 0078
Zuerich , 8091, Switzerland
Local Institution - 0157
Taipei , 11217, Taiwan
Local Institution - 0130
Kayseri , 38039, Turkey
Local Institution - 0098
London Greater London, N18 1, United Kingdom
Local Institution - 0097
Manchester Greater Manchester, M20 4, United Kingdom
Local Institution - 0053
Leeds Yorkshire, LS9 7, United Kingdom
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How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

541

Study ID:

NCT02041533

Recruitment Status:

Completed

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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