Chemoembolization for Lung Tumors

Inclusion Criteria:

Lung, endobronchial, pleural, or mediastinal metastases that are not responding to systemic chemotherapy, and that are not amenable to ablation, resection, or SBRT.
At least 18 years old.
ECOG performance status 0 or 1

Exclusion Criteria:

Primary lung cancer
>50% of a lung is replaced with tumor
Oxygen saturation <92% on room air
FEV1 <60%
Pulmonary hypertension (diagnosed or suspected on echocardiography, CT, MRI, or direct pressure measurement)
Recent pulmonary embolism (within 3 months)
Pulmonary arteriovenous malformation
Active lung infection (pneumonia, empyema, or lung abscess requiring therapy within 1 month)
Symptomatic heart failure (dyspnea, volume overload)
Left bundle branch block (contraindication to pulmonary angiography)
Renal failure (eGFR <30 mL/min/1.73m^2)
Pregnancy
Breastfeeding
Altered mental status that would interfere with consent or follow-up
Platelets < 100,000 (after transfusion, if needed)
INR>2 (after transfusion, if needed)
Hemoglobin <7 (after transfusion, if needed)
Hyperthyroidism (contraindication to lipiodol)
Planned radioactive iodine imaging or therapy (contraindication to lipiodol)
Allergy to lipiodol or mitomycin
Allergy to iodinated contrast that can not be treated with steroid / diphenhydramine premedication
Any condition that, in the opinion of the investigator, would interfere with evaluation of the investigational product or interpretation of subject safety or study results