Lung Cancer Clinical Trial
Chest Imaging, Breath, and Biomarkers in a Screening Trial
Summary
The investigators would like to see if lung cancer screening with chest x-rays,computer aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it is more responsive to treatment. The investigators would also like to see if early detection will reduce the incidence of symptomatic advanced lung cancer compared to no screening in former and current smokers with or without a family history of lung cancer who are 40-75 years old.
Full Description
The fight against lung cancer is waged on three major fronts: prevention, detection and treatment. Our goal is to determine if chest x-rays,computer aided detection (CAD)and a CT scan can detect disease earlier when treatment is more effective. If we improve the detection of disease, we will see if screening reduces the incidence of symptomatic advanced lung cancer relative to no screening in people at high risk to develop lung cancer.
Eligibility Criteria
Inclusion Criteria:
ages 40-75 years
If ages 40-59, then one of the following criteria needs to be met:
Current or ex-smoker with >25 pack years and a family history of lung cancer(parent or sibling) OR
current or ex-smoker with > 25 pack years and COPD OR
current or ex-smoker with a > 35 pack year history
If ages 60-75, then one of the following additional criteria needs to be met:
Current or ex-smoker with >25 pack years and a family history of lung cancer (parent or sibling) OR
Current or ex-smoker with >25 pack years and COPD OR
Current or ex-smoker with a >30 pack year history
Subject is able to return to Cleveland Clinic for annual follow-up screening
Subject is willing to sign a medical release form
Exclusion Criteria:
Current health requires oxygen
Have had a chest x-ray or CT of the chest within the last 6 months
Previous pneumonectomy
Lobectomy of the lung within the last 5 years
Diagnosed malignancy within the last 5 years, excluding non-melanoma skin cancer, carcinoma in situ of the cervix and localized prostate cancer
A medical condition that would prevent treatment for lung cancer
Within the last 6 weeks, one of the following has occured:
A new cough or chronic cough that has gotten worse
Either new shortness of breath, or any worsening of shortness of breath
A cough producing blood
Constant chest pain
Respiratory infection, pneumonia, or cold
Unintentional and unexplained weight loss greater than 5% of total body weight
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There is 1 Location for this study
Cleveland Ohio, 44195, United States
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