Lung Cancer Clinical Trial

Collection and Storage of Blood and Tissue Samples From Patients Who Are Undergoing Surgery For Lung Cancer

Summary

This research studies collecting and storing tissue and blood samples from patients with lung cancer who are undergoing surgery. Collecting and storing samples of tissue and blood from patients with lung cancer to study in the laboratory may help doctors learn more about changes that may occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.

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Full Description

OBJECTIVES:

To collect, catalog and store frozen samples of lung carcinoma and when possible, portions of involved lymph nodes, as well as adjacent grossly uninvolved lung tissue obtained from surgical specimens of patients undergoing surgical resection for previously untreated lung cancer as a source of quality DNA, messenger ribonucleic acid (mRNA) and protein for molecular analysis.
To collect, catalog and store frozen samples of blood pre- and post-resection from the same patients to provide a source of reference DNA to assess somatic mutations associated with tumor or preneoplastic "normal" lung, and to allow assessment of levels of circulating markers.
To associate these specimens with historical, clinical, pathological, and outcome information.

Grossly viable tumor and grossly normal lung tissue are identified and removed from patient surgical specimens and cryopreserved until shipment to the Cancer and Leukemia Group B (CALGB) Lung Cancer Tissue Bank for future use in research. Blood specimens are also collected prior to surgery and at 4-12 weeks post-surgery (before the start of adjuvant therapy) and shipped immediately to the Tissue Bank.

View Eligibility Criteria

Eligibility Criteria

Histologic Documentation: All patients with suspected or histologically documented previously untreated lung cancer undergoing surgical resection are eligible whether or not the patient participates in a CALGB-sponsored treatment trial; patients enrolled on a CALGB trial of preoperative chemotherapy for lung cancer will be eligible if a pre-treatment frozen sample of tumor (e.g., a positive lymph node from mediastinoscopy) can be submitted to the bank; patients enrolled on CALGB 140203, intraoperative sentinel node mapping in non-small cell lung cancer, are not eligible.
No patients with known infectious disease, such as human immunodeficiency virus (HIV), tuberculosis (TB), or hepatitis B, C

Study is for people with:

Lung Cancer

Estimated Enrollment:

500

Study ID:

NCT00899782

Recruitment Status:

Completed

Sponsor:

Alliance for Clinical Trials in Oncology

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There are 18 Locations for this study

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Tunnell Cancer Center at Beebe Medical Center
Lewes Delaware, 19958, United States
CCOP - Christiana Care Health Services
Newark Delaware, 19713, United States
Union Hospital of Cecil County
Elkton Maryland, 21921, United States
Dana-Farber/Brigham and Women's Cancer Center
Boston Massachusetts, 02115, United States
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
Boston Massachusetts, 02115, United States
Masonic Cancer Center at University of Minnesota
Minneapolis Minnesota, 55455, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia Missouri, 65203, United States
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
Saint Louis Missouri, 63110, United States
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees New Jersey, 08043, United States
Roswell Park Cancer Institute
Buffalo New York, 14263, United States
SUNY Upstate Medical University Hospital
Syracuse New York, 13210, United States
Veterans Affairs Medical Center - Asheville
Asheville North Carolina, 28805, United States
Duke Cancer Institute
Durham North Carolina, 27710, United States
Forbes Regional Hospital
Monroeville Pennsylvania, 15146, United States
Alle-Kiski Medical Center
Natrona Heights Pennsylvania, 15065, United States
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh Pennsylvania, 15212, United States
Rhode Island Hospital Comprehensive Cancer Center
Providence Rhode Island, 02903, United States
Miriam Hospital
Providence Rhode Island, 02906, United States
Fletcher Allen Health Care - University Health Center Campus
Burlington Vermont, 05401, United States

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Estimated Enrollment:

500

Study ID:

NCT00899782

Recruitment Status:

Completed

Sponsor:


Alliance for Clinical Trials in Oncology

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