Dasatinib in Advanced Non-small Cell Lung Cancer (NSCL) With Ex Vivo and In Vivo Assessment of Tumor Target Modulation

Inclusion Criteria:

Histologically or cytologically documented diagnosis of NSCLC that is advanced/metastatic (Stage IIIB/IV).
Performance Status (ECOG) 0-2
Previous chemotherapy with the exception of dasatinib. Patients who have had any type of previous chemotherapy regimens for non-small cell lung cancer are eligible.

Adequate Organ Function:

Total bilirubin < 2.0 times the institutional Upper Limit of Normal (ULN)
Hepatic enzymes (AST, ALT ) ≤ 2.5 times the institutional ULN
Serum Na, K+, Mg2+, Phosphate and Ca2+≥ Lower Limit of Normal (LLN)
Serum Creatinine < 1.5 time the institutional ULN
Hemoglobin, Neutrophil count, Platelets, prothrombin time (PT), partial thromboplastin time (PTT) all Grade 0-1
Ability to take oral medication

Concomitant Medications:

Agree to discontinue St. Johns Wort while receiving dasatinib therapy
Agree that IV bisphosphonates will be withheld for the first 8 weeks of dasatinib therapy due to risk of hypocalcemia.

Women of childbearing potential (WOCBP):

A negative serum or urine pregnancy test within 72 hours prior to the start of study drug administration
Persons of reproductive potential must agree to use and utilize an adequate method of contraception throughout treatment and for at least 4 weeks after study drug is stopped Prior to study enrollment.
Signed written informed consent including a HIPAA form according to institutional Guidelines

Exclusion Criteria:

No malignancy [other than the one treated in this study] which required radiotherapy or systemic treatment within the past 5 years.
Prior dasatinib therapy.

Concurrent medical condition which may increase the risk of toxicity, including:

Patients with severe pulmonary disease that increases the risk of toxicity related to dasatinib-induced pleural effusions. This includes chronic obstructive pulmonary disease or pleural effusions (malignant or benign) requiring chronic oxygen therapy or patients that have had prior pneumonectomy. Patients that have a pulmonary embolism and require oxygen therapy will be excluded but not those patients who have a pulmonary embolism but do not require oxygen therapy. Patients with active pleural effusions not controlled with pleurodesis will be excluded.

Cardiac Symptoms; any of the following should be considered for exclusion:

Uncontrolled angina, congestive heart failure or MI within (6 months)
Diagnosed congenital long QT syndrome
Any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes)
Prolonged QTc interval on pre-entry electrocardiogram (> 450 msec)
Patients with hypokalemia or hypomagnesemia if it cannot be corrected prior to dasatinib administration

History of significant bleeding disorder unrelated to cancer, including:

Diagnosed congenital bleeding disorders
Diagnosed acquired bleeding disorder within one year
Ongoing or recent (≤ 3 months) significant gastrointestinal bleeding

Concomitant Medications, any of the following should be considered for exclusion:

Category I drugs that are generally accepted to have a risk of causing Torsades de Pointes including: (Patients must discontinue drug 7 days prior to starting dasatinib)

quinidine, procainamide, disopyramide
amiodarone, sotalol, ibutilide, dofetilide
erythromycin, clarithromycin
chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide
cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine.

Women:

unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for at least 4 weeks after cessation of study drug,or
have a positive pregnancy test at baseline
pregnant or breastfeeding
Prisoners or persons who are compulsorily detained (involuntarily incarcerated)for treatment of either a psychiatric or physical (e.g., infectious) illness
Patients on systemic anticoagulation at risk of bleeding related to tumor biopsy that cannot be off anticoagulation per the discretion of their physician.