Lung Cancer Clinical Trial

Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

Summary

This trial will evaluate the safety and efficacy of pembrolizumab (MK-3475) in combination with platinum doublet neoadjuvant chemotherapy (NAC) before surgery [neoadjuvant phase], followed by pembrolizumab alone after surgery [adjuvant phase] in participants with resectable stage II, IIIA, and resectable IIIB (T3-4N2) non-small cell lung cancer (NSCLC). The primary hypotheses of this study are that neoadjuvant pembrolizumab (vs. placebo) in combination with NAC, followed by surgery and adjuvant pembrolizumab (vs. placebo) will improve: 1) event free survival (EFS) by biopsy assessed by local pathologist or by investigator-assessed imaging using Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1); and 2) overall survival (OS).

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Have previously untreated and pathologically confirmed resectable Stage II, IIIA, or IIIB (N2) NSCLC.
Be able to undergo protocol therapy, including necessary surgery. A positron emission tomography (PET) scan may be utilized as a surrogate for pathologic staging of N1 lymph nodes for participants with T2b and T4 tumors.
If male, must agree to use contraception or practice abstinence as well as refrain from donating sperm during the treatment period and for the time needed to eliminate each study intervention after the last dose of study intervention.
If female, may participate if not pregnant or breastfeeding, and at least one of the following conditions apply: 1) not a woman of childbearing potential (WOCBP); or 2) a WOCBP who agrees to follow contraceptive guidance during the treatment period and for the time needed to eliminate each study intervention after the last dose of study intervention and agrees not to donate eggs (ova, oocytes) to others or freeze/store for her own use for the purpose of reproduction during this period.
Have available formalin-fixed paraffin embedded (FFPE) tumor tissue sample blocks for submission. If blocks are not available, have unstained slides for submission for central programmed death-ligand 1 (PD-L1) testing.
Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 within 10 days of randomization.
Have adequate organ function.

Exclusion Criteria:

Has one of the following tumor locations/types:1) NSCLC involving the superior sulcus; 2) Large cell neuro-endocrine cancer (LCNEC); or 3) Sarcomatoid tumor.
Has a history of (non-infectious) pneumonitis /interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease that requires steroids.
Has an active infection requiring systemic therapy.
Has had an allogenic tissue/sold organ transplant.
Has a known severe hypersensitivity (≥ Grade 3) to pembrolizumab, its active substance and/or any of its excipients.
Has a known severe hypersensitivity (≥ Grade 3) to any of the study chemotherapy agents and/or to any of their excipients.
Has an active autoimmune disease that has required systemic treatment in past 2 years.
Has a known history of human immunodeficiency virus (HIV) infection.
Has a known history of Hepatitis B or Hepatitis C.
Has a known history of active tuberculosis.
Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the participant's participation for the full duration of the trial, or is not in the best interest of the participant to participate.
Has known psychiatric or substance abuse disorders that would interfere with cooperating with the requirements of the trial.
Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another co-inhibitory T-cell receptor.
Has received prior systemic anti-cancer therapy including investigational agents for the current malignancy prior to randomization/allocation.
Has received prior radiotherapy within 2 weeks of start of trial treatment.
Has received a live vaccine within 30 days prior to the first dose of trial drug.
Is currently participating in or has participated in a trial of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of trial treatment.
Has a diagnosis of immunodeficiency or is receiving either systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of trial drug.
Has a known additional malignancy that is progressing or requires active treatment within the past 5 years.

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

786

Study ID:

NCT03425643

Recruitment Status:

Active, not recruiting

Sponsor:

Merck Sharp & Dohme LLC

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 220 Locations for this study

See Locations Near You

Banner MD Anderson Cancer Center ( Site 0028)
Gilbert Arizona, 85234, United States
Western Regional Medical Center, Inc. ( Site 0050)
Goodyear Arizona, 85338, United States
University of Arizona Cancer Center - Dignity Health ( Site 0062)
Phoenix Arizona, 85004, United States
University of Arizona Cancer Center ( Site 0012)
Tucson Arizona, 85724, United States
Pacific Cancer Medical Center, Inc. ( Site 0004)
Anaheim California, 92801, United States
Providence Saint Joseph Medical Center ( Site 0061)
Burbank California, 91505, United States
Pacific Cancer Care ( Site 0035)
Monterey California, 93940, United States
John Wayne Cancer Institute ( Site 0049)
Santa Monica California, 90404, United States
St Joseph Heritage Healthcare ( Site 0040)
Santa Rosa California, 95403, United States
Stanford University, Stanford Cancer Center ( Site 0046)
Stanford California, 94305, United States
Hartford Hospital ( Site 0069)
Hartford Connecticut, 06102, United States
Helen F. Graham Cancer Center & Research Institute ( Site 0015)
Newark Delaware, 19718, United States
Mayo Clinic Jacksonville ( Site 0022)
Jacksonville Florida, 32224, United States
Miami Cancer Institute-Baptist Hospital ( Site 0068)
Miami Florida, 33176, United States
Southeastern Regional Medical Center ( Site 0051)
Newnan Georgia, 30265, United States
Northwest Oncology and Hematology ( Site 0001)
Elk Grove Village Illinois, 60007, United States
Ingalls Memorial Hospital ( Site 0044)
Harvey Illinois, 60426, United States
PPG-Oncology ( Site 0043)
Fort Wayne Indiana, 46845, United States
University of Iowa Hospital and Clinics ( Site 0010)
Iowa City Iowa, 52242, United States
Ashland-Bellefonte Cancer Center ( Site 0021)
Ashland Kentucky, 41101, United States
Harry & Jeanette Weinberg Cancer Institute ( Site 0081)
Baltimore Maryland, 21237, United States
Boston Medical Center ( Site 0057)
Boston Massachusetts, 02118, United States
UMass Memorial Medical Center ( Site 0030)
Worcester Massachusetts, 01655, United States
Henry Ford Health System ( Site 0031)
Detroit Michigan, 48202, United States
Herbert Herman Cancer Center, Sparrow Hospital ( Site 0034)
Lansing Michigan, 48912, United States
Mayo Clinic ( Site 0026)
Rochester Minnesota, 55905, United States
St. Vincent Healthcare Frontier Cancer Center ( Site 0005)
Billings Montana, 59102, United States
University of Nebraska Medical Center ( Site 0047)
Omaha Nebraska, 68198, United States
Memorial Sloan Kettering Cancer Center Basking Ridge ( Site 0074)
Basking Ridge New Jersey, 07920, United States
Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0077)
Middletown New Jersey, 07748, United States
MSKCC-Bergen ( Site 0075)
Montvale New Jersey, 07645, United States
St. Peter's Hospital Cancer Care Center ( Site 0039)
Albany New York, 12208, United States
Montefiore Einstein Center ( Site 0016)
Bronx New York, 10461, United States
Memorial Sloan-Kettering Cancer Center at Commack ( Site 0076)
Commack New York, 11725, United States
Memorial Sloan Kettering Cancer Center Westchester ( Site 0079)
Harrison New York, 10604, United States
Memorial Sloan Kettering Cancer Center ( Site 0060)
New York New York, 10065, United States
Stony Brook University Medical Center - Cancer Center ( Site 0019)
Stony Brook New York, 11794, United States
Memorial Sloan Kettering Cancer Center - Nassau ( Site 0078)
Uniondale New York, 11553, United States
White Plains Hospital Center for Cancer Care ( Site 0007)
White Plains New York, 10601, United States
Southwestern Regional Medical Center, Inc. ( Site 0054)
Tulsa Oklahoma, 74133, United States
OHSU Center for Health & Healing ( Site 1006)
Portland Oregon, 97239, United States
UPMC Pinnacle Health System - East Location ( Site 0063)
Harrisburg Pennsylvania, 17109, United States
Cancer Treatment Centers of America-Eastern Regional Medical Center ( Site 0053)
Philadelphia Pennsylvania, 19124, United States
Allegheny General Hospital ( Site 0009)
Pittsburgh Pennsylvania, 15212, United States
UPMC Hillman Cancer Centers ( Site 0041)
Pittsburgh Pennsylvania, 15232, United States
VA Pittsburgh Healthcare System ( Site 0052)
Pittsburgh Pennsylvania, 15240, United States
Saint Francis Cancer Center ( Site 0096)
Greenville South Carolina, 29607, United States
Emily Couric Clinical Cancer Center ( Site 0013)
Charlottesville Virginia, 22903, United States
Inova Schar Cancer Institute ( Site 0032)
Fairfax Virginia, 22031, United States
Virginia Cancer Specialists, PC ( Site 0080)
Fairfax Virginia, 22031, United States
Providence Regional Cancer Partnership ( Site 0065)
Everett Washington, 98201, United States
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0136)
Berazategui Buenos Aires, B1884, Argentina
Hospital Privado de Comunidad. ( Site 0130)
Mar del Plata Buenos Aires, B7602, Argentina
Hospital Universitario Austral ( Site 0127)
Pilar Buenos Aires, B1629, Argentina
Fundacion Favaloro ( Site 0128)
Ciudad de Buenos Aires Caba, C1093, Argentina
Sanatorio Britanico ( Site 0125)
Rosario Santa Fe, S2000, Argentina
Sanatorio Parque ( Site 0135)
Rosario Santa Fe, S2000, Argentina
Hospital Provincial del Centenario ( Site 0131)
Rosario Santa Fe, S2002, Argentina
Hospital Privado Universitario de Córdoba ( Site 0139)
Cordoba , 5016, Argentina
Sanatorio Allende ( Site 0129)
Cordoba , X5000, Argentina
CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0133)
San Juan , J5402, Argentina
Orange Health Services ( Site 0624)
Orange New South Wales, 2800, Australia
Westmead Hospital ( Site 0621)
Westmead New South Wales, 2145, Australia
AZ Sint-Maarten ( Site 0226)
Mechelen Antwerpen, 2800, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0223)
Liège Liege, 4000, Belgium
UZ Gent ( Site 0224)
Gent Oost-Vlaanderen, 9000, Belgium
AZ Nikolaas ( Site 0225)
Sint-Niklaas Oost-Vlaanderen, 9100, Belgium
UZ Leuven ( Site 0221)
Leuven Vlaams-Brabant, 3000, Belgium
AZ Delta ( Site 0222)
Roeselare West-Vlaanderen, 8800, Belgium
Centro Regional Integrado de Oncologia ( Site 0160)
Fortaleza Ceara, 60336, Brazil
Instituto do Cancer do Ceara ( Site 0152)
Fortaleza Ceara, 60430, Brazil
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul ( Site 0159)
Brasilia Distrito Federal, 70200, Brazil
Liga Norte Riograndense Contra o Cancer ( Site 0150)
Natal Rio Grande Do Norte, 59075, Brazil
Hospital de Caridade de Ijui ( Site 0153)
Ijui Rio Grande Do Sul, 98700, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0146)
Porto Alegre Rio Grande Do Sul, 90610, Brazil
Hospital Nossa Senhora da Conceicao ( Site 0145)
Porto Alegre Rio Grande Do Sul, 91350, Brazil
YNOVA Pesquisa Clinica ( Site 0823)
Florianopolis Santa Catarina, 88020, Brazil
Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0144)
Barretos Sao Paulo, 14784, Brazil
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0149)
Rio de Janeiro , 20230, Brazil
Hospital Paulistano - Amil Clinical Research ( Site 0822)
Sao Paulo , 01321, Brazil
Hospital Alemao Oswaldo Cruz ( Site 0158)
Sao Paulo , 01327, Brazil
Princess Margaret Cancer Centre ( Site 0109)
Toronto Ontario, M5G 2, Canada
CIUSSS du Saguenay-Lac-St-Jean ( Site 0101)
Chicoutimi Quebec, G7H 5, Canada
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0110)
Montreal Quebec, H2X 0, Canada
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0104)
Montreal Quebec, H3T 1, Canada
McGill University Health Centre ( Site 0111)
Montreal Quebec, H4A 3, Canada
Tianjin Medical University General Hospital ( Site 0806)
Tianjin Anhui, 30005, China
Beijing Cancer Hospital ( Site 0810)
Beijing Beijing, 10001, China
Beijing Cancer Hospital ( Site 0811)
Beijing Beijing, 10001, China
Cancer Hospital Chinese Academy of Medical Sciences ( Site 0801)
Beijing Beijing, 10002, China
Peking University Third Hospital ( Site 0812)
Beijing Beijing, 10019, China
Peking Union Medical College Hospital ( Site 0809)
Beijing Beijing, 10073, China
Sun Yat-Sen University Cancer Center ( Site 0816)
Guangzhou Guangdong, 51006, China
Hunan Cancer Hospital ( Site 0815)
Changsha Hunan, 41001, China
Fudan University Shanghai Cancer Center ( Site 0813)
Shanghai Shanghai, 20003, China
Zhongshan Hospital of Fudan University ( Site 0808)
Shanghai Shanghai, 20003, China
Shanghai Pulmonary Hospital-Thoracic Surgery department ( Site 0817)
Shanghai Shanghai, 20043, China
Tang Du Hospital ( Site 0803)
XI An Shanxi, 71003, China
The First Affiliated Hospital of Zhejiang University ( Site 0804)
Hangzhou Zhejiang, 31000, China
Zhejiang Cancer Hospital.... ( Site 0814)
Hangzhou Zhejiang, 31002, China
Hwa Mei Hospital University of Chinese Academy of Sciences ( Site 0802)
Ningbo Zhejiang, 31501, China
SA Pohja-Eesti Regionaalhaigla ( Site 1100)
Tallinn Harjumaa, 13419, Estonia
Hopital Foch ( Site 0243)
Suresnes Ain, 92150, France
Nouvel Hopital Civil ( Site 0255)
Strasbourg Bas-Rhin, 67091, France
CHU de Toulouse - Hopital Larrey ( Site 0258)
Toulouse Haute-Garonne, 31100, France
Clinique Francois Chenieux ( Site 0246)
Limoges Haute-Vienne, 87039, France
Hospices Civils de Lyon Centre Hospitalier Lyon Sud ( Site 0241)
Pierre-Benite Rhone-Alpes, 69310, France
Centre Hospitalier Metropole Savoie Site de Chambery ( Site 0245)
Chambery Savoie, 73011, France
Centre Hospitalier Annecy Genevois ( Site 0242)
Pringy Savoie, 74374, France
CHU de Rouen ( Site 0252)
Rouen Seine-Maritime, 76031, France
Hôpital Avicenne - Service d oncologie medicale ( Site 0249)
Bobigny Seine-Saint-Denis, 93000, France
H.I.A. Sainte-Anne ( Site 0251)
Toulon Var, 83800, France
Institut Curie ( Site 0250)
Paris , 75248, France
Klinikum Esslingen GmbH ( Site 0875)
Esslingen Baden-Wurttemberg, 73730, Germany
LKI Lungenfachklinik Immenhausen ( Site 0268)
Immenhausen Hessen, 34376, Germany
Florence Nightingale Krankenhaus ( Site 0874)
Duesseldorf Nordrhein-Westfalen, 40489, Germany
Lungenklinik Hemer ( Site 0269)
Hemer Nordrhein-Westfalen, 58675, Germany
Mathias Spital Rheine ( Site 0261)
Rheine Nordrhein-Westfalen, 48431, Germany
Katholisches Klinikum Koblenz Haus Marienhof ( Site 0873)
Koblenz Rheinland-Pfalz, 56073, Germany
Universitaetsklinikum Carl Gustav Carus ( Site 0273)
Dresden Sachsen, 01307, Germany
Universitaetsklinikum Leipzig AOeR ( Site 0277)
Leipzig Sachsen, 04103, Germany
LungenClinic Grosshansdorf GmbH ( Site 0267)
Grosshansdorf Schleswig-Holstein, 22927, Germany
Universitaetsklinikum Schleswig Holstein ( Site 0871)
Kiel Schleswig-Holstein, 24105, Germany
Zentralklinik Bad Berka GmbH ( Site 0264)
Bad Berka Thuringen, 99437, Germany
SRH Waldklinikum Gera GmbH ( Site 0272)
Gera Thuringen, 07548, Germany
Evangelische Lungenklinik Berlin ( Site 0274)
Berlin , 13125, Germany
HELIOS Klinikum Emil von Behring ( Site 0280)
Berlin , 14165, Germany
Asklepios Klinikum Hamburg ( Site 0271)
Hamburg , 21075, Germany
Cork University Hospital ( Site 0452)
Wilton Cork, , Ireland
St James Hospital ( Site 0451)
Dublin , D08 K, Ireland
Mid Western Cancer Centre ( Site 0450)
Limerick , V98F8, Ireland
Istituto Nazionale Tumori ( Site 0309)
Milano Abruzzo, 20133, Italy
Azienda Ospedaliera dei Colli V. Monaldi ( Site 0301)
Napoli Campania, 80131, Italy
IRST-Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori ( Site 0300)
Meldola Forli-Cesena, 47014, Italy
Istituto Clinico Humanitas Research Hospital ( Site 0314)
Rozzano Lombardia, 20089, Italy
ASST Grande Ospedale Metropolitano Niguarda-Oncologia Falck ( Site 0315)
Milan Milano, 20162, Italy
Azienda Ospedaliera San Gerardo ( Site 0308)
Monza Monza E Brianza, 20900, Italy
AOU San Luigi Gonzaga di Orbassano ( Site 0313)
Orbassano Torino, 10043, Italy
Azienda Ospedaliera Spedali Civili di Brescia ( Site 0307)
Brescia , 25123, Italy
IRCCS Ospedale San Raffaele di Milano ( Site 0303)
Milano , 20132, Italy
Azienda Ospedaliera San Camillo Forlanini ( Site 0311)
Roma , 00152, Italy
Aichi Cancer Center Hospital ( Site 0765)
Nagoya Aichi, 464-8, Japan
National Cancer Center Hospital East ( Site 0761)
Kashiwa Chiba, 277-8, Japan
HP of the Univ. of Occupational and Environmental Health, Japan ( Site 0770)
Kitakyushu Fukuoka, 807-8, Japan
Hyogo Cancer Center ( Site 0764)
Akashi Hyogo, 673-8, Japan
St. Marianna University School of Medicine Hospital ( Site 0769)
Kawasaki Kanagawa, 216-8, Japan
Kanagawa Cancer Center ( Site 0763)
Yokohama Kanagawa, 241-8, Japan
Oita University Hospital ( Site 0766)
Yufu Oita, 879-5, Japan
Fukushima Medical University Hospital ( Site 0772)
Fukushima , 960-1, Japan
Hiroshima University Hospital ( Site 0762)
Hiroshima , 734-8, Japan
National Cancer Center Hospital ( Site 0767)
Tokyo , 104-0, Japan
Juntendo University Hospital ( Site 0768)
Tokyo , 113-8, Japan
Tokyo Medical University Hospital ( Site 0771)
Tokyo , 160-0, Japan
National Cancer Center ( Site 0702)
Gyeonggi-do Kyonggi-do, 10408, Korea, Republic of
The Catholic University of Korea St. Vincent s Hospital ( Site 0705)
Gyeonggi-do Kyonggi-do, 16247, Korea, Republic of
Asan Medical Center ( Site 0701)
Seoul , 05505, Korea, Republic of
Samsung Medical Center ( Site 0704)
Seoul , 06351, Korea, Republic of
SMG-SNU Boramae Medical Center ( Site 0707)
Seoul , 07071, Korea, Republic of
Pauls Stradins Clinical University Hospital ( Site 0911)
Riga , 1002, Latvia
Riga East Clinical University Hospital ( Site 0912)
Riga , 1079, Latvia
LSMUL Kauno Klinikos ( Site 0932)
Kaunas , 50161, Lithuania
Nacionalinis Vezio Institutas ( Site 0931)
Vilnius , 08406, Lithuania
Sarawak General Hospital ( Site 0782)
Kuching Sarawak, 93586, Malaysia
University Malaya Medical Centre ( Site 0781)
Kuala Lumpur , 59100, Malaysia
Centrum Pulmonologii i Torakochirurgii w Bystrej ( Site 0484)
Bystra Dolnoslaskie, 43-36, Poland
Dolnoslaskie Centrum Onkologii. ( Site 0491)
Wroclaw Dolnoslaskie, 53-41, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0488)
Bydgoszcz Kujawsko-pomorskie, 85-79, Poland
Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi ( Site 0493)
Lodz Lodzkie, 93-51, Poland
Szpital Specjalistyczny w Prabutach Sp. z o.o. ( Site 0483)
Prabuty Pomorskie, 82-55, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 0487)
Poznan Wielkopolskie, 60-56, Poland
S C Pelican Impex SRL ( Site 0506)
Oradea Bihor, 41045, Romania
Centrul Medical Medicover Victoria ( Site 0514)
Bucharest Bucuresti, 01062, Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0501)
Cluj Napoca Cluj, 40001, Romania
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0515)
Cluj-Napoca Cluj, 40001, Romania
SC Radiotherapy Center Cluj SRL ( Site 0509)
Comuna Floresti Cluj, 40728, Romania
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0504)
Craiova Dolj, 20034, Romania
S.C.R.T.C.Radiology Therapeutic Center SRL ( Site 0511)
Otopeni Ilfov, 07510, Romania
S C Oncocenter Oncologie Medicala S R L ( Site 0505)
Timisoara Timis, 30016, Romania
Spitalul Sf. Constantin ( Site 0512)
Brasov , 50009, Romania
Euroclinic Hospital Bucharest ( Site 0510)
Bucuresti , 01446, Romania
S.C.Focus Lab Plus S.R.L ( Site 0513)
Bucuresti , 02138, Romania
Spitalul clinic Judetean de urgenta Constanta ( Site 0508)
Constanta , 90059, Romania
Spitalul Judetean de Urgenta .Sf. Ioan cel Nou. ( Site 0503)
Suceava , 72023, Romania
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0530)
Chelyabinsk Chelyabinskaya Oblast, 45408, Russian Federation
N.N. Blokhin NMRCO ( Site 0521)
Moscow Moskva, 11547, Russian Federation
National Medical Research Radiology Centre ( Site 0535)
Moscow Moskva, 12528, Russian Federation
Medical Rehabilitation Center ( Site 0534)
Moscow Moskva, 12536, Russian Federation
SBHI Leningrad Regional Clinical Hospital ( Site 0524)
Saint Petersburg Sankt-Peterburg, 19429, Russian Federation
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 0533)
Saint Petersburg Sankt-Peterburg, 19775, Russian Federation
Municipal Clinical Oncology Center ( Site 0523)
Saint Petersburg Sankt-Peterburg, 19825, Russian Federation
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0529)
Kazan Tatarstan, Respublika, 42002, Russian Federation
Tomsk Scientific Research Institute of Oncology ( Site 0526)
Tomsk Tomskaya Oblast, 63402, Russian Federation
Wits Clinical Research ( Site 0570)
Parktown-Johannesburg Gauteng, 2193, South Africa
Wilgers Oncology Centre ( Site 0573)
Pretoria Gauteng, 0081, South Africa
The Oncology Centre ( Site 0571)
Durban Kwazulu-Natal, 4001, South Africa
Cape Town Oncology Trials Pty Ltd ( Site 0572)
Kraaifontein Western Cape, 7570, South Africa
Hospital Germans Trias i Pujol. ICO de Badalona ( Site 0381)
Badalona Barcelona, 08916, Spain
Instituto Catalan de Oncologia - ICO ( Site 0388)
L Hospitalet De Llobregat Barcelona, 08908, Spain
Hospital Universitario de Girona Doctor Josep Trueta ( Site 0386)
Girona La Coruna, 17007, Spain
Hospital Universitario Insular de Gran Canaria ( Site 0383)
Las Palmas de Gran Canaria Las Palmas, 35001, Spain
Hospital de la Santa Creu i Sant Pau ( Site 0385)
Barcelona , 08025, Spain
Hospital Universitari Vall d Hebron ( Site 0389)
Barcelona , 08035, Spain
Hospital General Universitario Gregorio Maranon ( Site 0382)
Madrid , 28009, Spain
Hospital Virgen del Rocio ( Site 0387)
Sevilla , 41013, Spain
Kaohsiung Chang Gung Memorial Hospital ( Site 0725)
Kaohsiung , 83301, Taiwan
China Medical University Hospital ( Site 0724)
Taichung , 40447, Taiwan
National Taiwan University Hospital ( Site 0721)
Taipei , 10048, Taiwan
Taipei Veterans General Hospital ( Site 0722)
Taipei , 112, Taiwan
Tri-Service General Hospital ( Site 0726)
Taipei , 114, Taiwan
Chang Gung Medical Foundation.Linkou Branch ( Site 0723)
Taoyuan , 333, Taiwan
Cherkassy Regional Oncological Center ( Site 0613)
Cherkasy Cherkaska Oblast, 18009, Ukraine
City Clinical Hosp.4 of DCC ( Site 0607)
Dnipro Dnipropetrovska Oblast, 49102, Ukraine
MI Precarpathian Clinical Oncology Center ( Site 0603)
Ivano-Frankivsk Ivano-Frankivska Oblast, 76018, Ukraine
MI KhRC Kherson Regional Oncology Dispensary ( Site 0614)
Kherson Khersonska Oblast, 73000, Ukraine
PP PPC Acinus Medical and Diagnostic Centre ( Site 0609)
Kropyvnytsky Kirovohradska Oblast, 25006, Ukraine
National Cancer Institute of the MoH of Ukraine ( Site 0605)
Kyiv Kyivska Oblast, 03022, Ukraine
Kyiv City Clinical Oncological Center ( Site 0601)
Kyiv Kyivska Oblast, 03115, Ukraine
MI Odessa Regional Oncological Centre ( Site 0608)
Odesa Odeska Oblast, 65055, Ukraine
Zaporizhzhya Regional Clinical Oncology Center ( Site 0606)
Zaporizhzhya Zaporizka Oblast, 69040, Ukraine
Leicester Royal Infirmary ( Site 0447)
Leicester Leicestershire, LE1 5, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0456)
Wirral Liverpool, CH63 , United Kingdom
Royal Marsden NHS Foundation Trust ( Site 0458)
London London, City Of, SW3 6, United Kingdom
Royal Marsden Hospital ( Site 0457)
Sutton London, City Of, SM2 5, United Kingdom
Nottingham City Hospital Campus ( Site 0441)
Nottingham Nottinghamshire, NG5 1, United Kingdom
Heartlands Hospital in Birmingham ( Site 0455)
Birmingham , B9 5S, United Kingdom
Freeman Hospital ( Site 0444)
Newcastle upon Tyne , NE7 7, United Kingdom
Plymouth Hospitals NHS Trust ( Site 0443)
Plymouth , PL6 8, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

786

Study ID:

NCT03425643

Recruitment Status:

Active, not recruiting

Sponsor:


Merck Sharp & Dohme LLC

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.