Evaluating Crizotinib in the Neoadjuvant Setting in Patients With Non-small Cell Lung Cancer

Inclusion Criteria:

Stage IA-IIIA NSCLC by 8th edition AJCC staging (that is deemed to be surgically resectable by a board certified thoracic surgeon.
Staging by PET-CT scan and MRI brain showing no evidence of metastatic disease (mediastinoscopy is not required unless imaging is indeterminate and is then considered standard of care)
Documented evidence of an ALK rearrangement (by FISH, IHC, or NGS), ROS1 rearrangement (by FISH or NGS), or MET oncogene as defined by MET exon 14 skipping (NGS), MET Y1003X mutation or MET gene fusion (NGS) in NSCLC tumor specimen by a CLIA-approved laboratory.
Measurable disease defined by RECIST 1.1 criteria.
Life expectancy of at least 24 months.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.
Age ≥ 18 years
Have normal QT interval on ECG evaluation QT corrected Fridericia (QTcF) of ≤ 450 ms in males or ≤ 470 ms in females

Adequate organ function:

Absolute neutrophil count (ANC) ≥1500/µL
Platelets ≥75,000/µL
Hemoglobin ≥ 10g/dL
AST /ALT ≤ 2.5 x upper limit of normal (ULN)
Total serum bilirubin ≤ 1.5 x ULN
Serum creatinine ≤ 1.5 x UNL
Serum amylase/lipase ≤ 1.5 x UNL
Negative serum pregnancy test within 7 days of D1 of treatment in women of child bearing potential.
If fertile, willing to use highly effective form of contraception (defined as a combination of at least two of the following methods: condom or other barrier methods, oral contraceptives, implantable contraceptives, intrauterine devices) during the dosing period and for at least 4 months after the dosing period.
Ability to provide signed informed consent and willing and able to comply with all study requirements.

Exclusion Criteria:

Stage IIIB or IV NSCLC.
History or the presence of pulmonary interstitial disease, or drug-related pneumonitis.
Malabsorption syndrome or other GI illness that could affect oral absorption of the study drug
Inability to swallow oral medications

Have significant, uncontrolled or active cardiovascular disease, specifically including but restricted to:

Myocardial infarction (MI) within 6 months of trial enrollment
Unstable angina within 6 months of trial enrollment
Congestive heart failure (CHF) with 6 months prior to trial enrollment
Any history of ventricular arrhythmia
Cerebrovascular accident or transient ischemic attack within 6 months of D1 of treatment
Clinically significant atrial arrhythmia or severe baseline bradycardia defined as resting heart rate < 50 beat per minute
Uncontrolled hypertension defined as baseline SBP> 160 and DBP > 100 on 3 separate clinic visits or past history of hypertensive urgency, emergency or encephalopathy
Have active infection requiring antibiotics
Pregnant or lactating female.
Prior treatment with an ALK, ROS1 or MET inhibitor
Any prior anticancer therapy for this diagnosis
Any active cancer diagnosis (basal or squamous cell cancers allowed) within the last 5 years for which the patient is receiving active therapy or which is untreated. Any cancer diagnosis within the last 5 years that is considered "treated" and/ or on surveillance may be included in the trial.
Have any condition or illness that, in the opinion of the investigator would compromise patient safety or interfere with evaluation of the study drug (including but not limited to HIV and HCV)