Lung Cancer Clinical Trial

Expression Analysis of Specific Markers in Non-small Cell Lung Cancer or Melanoma

Summary

This study intends to analyze the expression of specific sets of markers in tumor samples and in serum from patients with Non-Small Cell lung Cancer (NSCLC) or Stage III or IV melanoma. The data obtained in this study will be used to guide future development of immunotherapies for melanoma or NSCLC patients. Moreover, the analyses will contribute to definition of markers potentially predictive of clinical response to specific anticancer therapies.

View Full Description

Full Description

This protocol posting has been updated due to a protocol amendment.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

The patient (male or female) is at least 18 years of age.
The investigator believes that the patient can and will comply with the requirements of the protocol.
The patient has given his/her written informed consent to take part in the study.
The investigator believes that it will be possible to obtain a tumor tissue sample of at least 3 mm3 before treatment and all required tumor tissues several weeks after the initiation of the treatment.
The patient has cancer in one of the following histological types, fulfilling all of the characteristics listed for the respective cancer type:

Cutaneous Melanoma, unresectable stage III or stage IV • The patient has histologically documented unresectable stage III or stage IV metastatic cutaneous melanoma.

AND

• The patient is a candidate for one of the following treatments:

First-line chemotherapy with DTIC or TMZ as monotherapy [group ME1],
First-line chemotherapy with an agent other than DTIC/TMZ as monotherapy or a combination (that may, but need not, include DTIC, TMZ, IL-2 or IFNγ) [group ME2],
Second- or higherline chemotherapy with any agent or combination of agents (that may, but need not, include DTIC, TMZ, IL-2 or IFNγ ; i.e., systemic chemotherapy after isolated limb perfusion should be considered as second-line) [group ME3],
Palliative irradiation of skin lesion(s)/region, irrespective of what line of treatment is planned [group ME4],
Topical palliative treatment by imiquimod of skin lesion(s), irrespective of what line of treatment is planned [group ME5].
First or higher line treatment with ipilimumab [group ME6].

NSCLC, any stage if the patient is eligible for neo-adjuvant chemotherapy with subsequent resection • The patient has NSCLC at any stage (as defined by the International Staging System) if the patient is eligible for neo-adjuvant chemotherapy with subsequent resection.

AND

• The patient is a candidate for chemo(radio)-therapy induction doublet neoadjuvant chemotherapy with platinum plus a second chemotherapy drug.

[Note: Induction radiotherapy is permitted.]

The recruitment of patients to the NSCLC group has been ended prematurely.

Exclusion Criteria:

The patient has any family history of congenital or hereditary immunodeficiency.
The patient has in the two weeks before baseline received any of the following:
Chemotherapeutic agents,
Immune-modulating agents such as (but not confined to) IFN-α, IL-2, BCG and anti-cancer therapeutic vaccines,
Immunosuppressive agents such as corticosteroids [except for prednisone, or equivalent, <0.5 mg/kg/day (absolute maximum 40 mg/day, maximum duration of treatment three weeks), and inhaled and topical steroids, which are allowed].
The patient is currently receiving an anti cancer treatment in another clinical trial. However, if the patient has finished the drug administration phase of that trial and has entered the follow-up phase, this patient can be included.

Study is for people with:

Lung Cancer

Estimated Enrollment:

88

Study ID:

NCT00685750

Recruitment Status:

Terminated

Sponsor:

GlaxoSmithKline

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 34 Locations for this study

See Locations Near You

GSK Investigational Site
Los Angeles California, 90025, United States
GSK Investigational Site
Park Ridge Illinois, 60068, United States
GSK Investigational Site
Saint Louis Missouri, 63110, United States
GSK Investigational Site
Murray Utah, 84107, United States
GSK Investigational Site
Dijon , 21079, France
GSK Investigational Site
Lille , 59037, France
GSK Investigational Site
Marseille Cedex 5 , 13385, France
GSK Investigational Site
Marseille , 13274, France
GSK Investigational Site
Montpellier , 34295, France
GSK Investigational Site
Nantes , 44093, France
GSK Investigational Site
Paris , 75012, France
GSK Investigational Site
Freiburg Baden-Wuerttemberg, 79106, Germany
GSK Investigational Site
Heidelberg Baden-Wuerttemberg, 69126, Germany
GSK Investigational Site
Mannheim Baden-Wuerttemberg, 68167, Germany
GSK Investigational Site
Tuebingen Baden-Wuerttemberg, 72076, Germany
GSK Investigational Site
Regensburg Bayern, 93049, Germany
GSK Investigational Site
Wuerzburg Bayern, 97080, Germany
GSK Investigational Site
Greifswald Mecklenburg-Vorpommern, 17487, Germany
GSK Investigational Site
Hannover Niedersachsen, 30625, Germany
GSK Investigational Site
Ostercappeln Niedersachsen, 49179, Germany
GSK Investigational Site
Hemer Nordrhein-Westfalen, 58675, Germany
GSK Investigational Site
Koeln Nordrhein-Westfalen, 51109, Germany
GSK Investigational Site
Mainz Rheinland-Pfalz, 55131, Germany
GSK Investigational Site
Grosshansdorf Schleswig-Holstein, 22927, Germany
GSK Investigational Site
Kiel Schleswig-Holstein, 24105, Germany
GSK Investigational Site
Berlin , 12200, Germany
GSK Investigational Site
Hamburg , 20246, Germany
GSK Investigational Site
Napoli Campania, 80131, Italy
GSK Investigational Site
Milano Lombardia, 20141, Italy
GSK Investigational Site
Siena Toscana, 53100, Italy
GSK Investigational Site
Padova Veneto, 35128, Italy
GSK Investigational Site
Göteborg , SE-41, Sweden
GSK Investigational Site
Lund , SE-22, Sweden
GSK Investigational Site
Stockholm , SE-17, Sweden

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Estimated Enrollment:

88

Study ID:

NCT00685750

Recruitment Status:

Terminated

Sponsor:


GlaxoSmithKline

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider