Identification of a Plasma Proteomic Signature for Lung Cancer

Inclusion Criteria:

age ≥ 40
any smoking status, e.g. current, former, or never
co-morbid conditions, e.g. COPD
Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity
Pathology: malignant - adenocarcinoma, squamous, or large cell
Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)
Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)
Clinical stage, Regional lymph nodes: N0 or N1 only
Clinical stage, Distant metastasis: M0 only

Exclusion Criteria:

prior malignancy within 5 years of lung nodule diagnosis
No nodule size available
No pathology data available for those with
Current diagnosis of non-small cell lung cancer
Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1