Lung Cancer Clinical Trial

KRT-232 in Subjects With Relapsed or Refractory Small Cell Lung Cancer

Summary

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, for the treatment of patients with relapsed or refractory small cell lung cancer.

This study will be conducted in 2 parts. Part 1 will evaluate two treatment arms, each with a different KRT-232 dose. Part 2 will continue the evaluation of the selected treatment arms from Part 1.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically or cytologically confirmed diagnosis of SCLC documented as TP53WT
Disease must be measurable per RECIST Version 1.1
Evidence of radiographic progression during or after at least one prior platinum-containing therapy with no curative therapy available. Subjects who have received only one prior line of therapy must not be candidates for platinum-based regimens at relapse.
Subjects must have received a checkpoint inhibitor (PD-1 or PD-L1) unless contraindicated if checkpoint inhibitors are approved and available.
ECOG ≤ 2

Exclusion Criteria:

Symptomatic or uncontrolled central nervous system (CNS) metastases.
Prior treatment with MDM2 inhibitors
Chemotherapy, immune therapy, cytokine therapy, or any investigational therapy within 14 days prior to the first dose of study treatment
Grade 2 or higher QTc prolongation (> 480 milliseconds per NCI-CTCAE criteria, version 5.0)
History of major organ transplant

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

38

Study ID:

NCT05027867

Recruitment Status:

Recruiting

Sponsor:

Kartos Therapeutics, Inc.

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 30 Locations for this study

See Locations Near You

Florida Cancer Specialists - 3840 Broadway
Fort Myers Florida, 33901, United States More Info
Kim Woosley
Contact
239-274-9930
[email protected]
Fadi Kayali, MD
Principal Investigator
Florida Cancer Specialists - 560 Jackson St, Suite 220
Saint Petersburg Florida, 33705, United States More Info
Kristen Borresen
Contact
813-782-3727
[email protected]
Vijay Patel, MD
Principal Investigator
Florida Cancer Specialists
West Palm Beach Florida, 33401, United States More Info
Ofelia Betancourt
Contact
561-366-4100
[email protected]
Eric Harris, MD
Principal Investigator
Northwest Georgia Oncology Centers
Marietta Georgia, 30060, United States More Info
Kristine Parker
Contact
770-812-1928
[email protected]
Steven McCune, MD
Principal Investigator
Hematology Oncology Clinic
Baton Rouge Louisiana, 70809, United States More Info
Aimee Alumbaugh
Contact
225-761-3951
[email protected]
Michael Castine, MD
Principal Investigator
University Hospitals Cleveland Medical Center
Cleveland Ohio, 44106, United States More Info
Carly Croyle
Contact
216-844-8017
[email protected]
Leslie Ortega
Contact
(216) 844-3951
[email protected]
Afshin Dowlati, MD
Principal Investigator
Mark H Zangmeister Center - 3100 Plaza Properties Boulevard
Columbus Ohio, 43213, United States More Info
Nancy Zangmeister
Contact
614-383-6236
[email protected]
Jorge Rios Perez, MD
Principal Investigator
SCRI Tennessee Oncology Chattanooga
Chattanooga Tennessee, 37404, United States More Info
Diana Dotson
Contact
423-622-6212
[email protected]
Davey Daniel, MD
Principal Investigator
SCRI Tennessee Oncology Nashville
Nashville Tennessee, 37205, United States More Info
Misty Moore
Contact
615-524-4025
[email protected]
Melissa Johnson, MD
Principal Investigator
Centre Hospitalier de Mulhouse - Hopital Emile Muller
Mulhouse France/Haut-Rhin, 68000, France More Info
Virginie Birr
Contact
[email protected]
Didier Debieuvre, MD
Principal Investigator
Edog - Ico - Ppds
Angers Maine-et-Loire, 49933, France More Info
Christine Moreira
Contact
33240679978
[email protected]
Sandrine Hiret, MD
Principal Investigator
Hôpital Louis Pradel
Bron Rhône, 69677, France More Info
Raphaële Guelminger
Contact
+33478863780
[email protected]
Laurine Favre
Contact
+33472357074
[email protected]
Sébastien Couraud, MD
Principal Investigator
Hospices Civils de Lyon
Lyon Rhône, 69495, France More Info
Audrey Serres
Contact
+33478865924
[email protected]
Ilhem Bensekka
Contact
+33478863708
[email protected]
Sebastian Couraud, MD
Principal Investigator
Hôpital de La Croix Rousse
Pierre-Bénite Rhône, 69310, France More Info
Camille Folliet
Contact
+33426732979
[email protected]
Sébastien Couraud, MD
Principal Investigator
EDOG - Institut Bergonie - PPDS
Bordeaux , 33000, France More Info
E Ducasse
Contact
33556333230
[email protected]
S Jallier
Contact
[email protected]
Sophie Cousin, MD
Principal Investigator
CHU de Grenoble
Grenoble , 38043, France More Info
Cécile Glommeau
Contact
[email protected]
Denis Moro-Sibilot, MD
Principal Investigator
Hopital Nord AP-HM
Marseille , 13915, France More Info
Manon Cossu
Contact
33491965901
[email protected]
Fabienne Palmerini
Contact
[email protected]
Laurent Greillier, MD
Principal Investigator
Lungenfachklinik Immenhausen
Immenhausen Hessen, 34376, Germany More Info
Sabrina Adomeit
Contact
+4956735011577
[email protected]
Katrin Schwedler
Contact
+495673501577
[email protected]
Achim Rittmeyer, MD
Principal Investigator
Evangelische Lungenklinik Berlin
Berlin , 13125, Germany More Info
Norman Golchert
Contact
+493094802569
[email protected]
Petra Schmutz
Contact
+4903094802532
[email protected]
Christian Grohé, MD
Principal Investigator
Chungbuk National University Hospital
Cheongju-si Chungcheongbuk-do, 28644, Korea, Republic of More Info
Min Kyung Hwang
Contact
+82432696897
Ki Hyeong Lee, MD
Principal Investigator
CHA Bundang Medical Center, CHA University
Seongnam-si Gyeonggido, 13520, Korea, Republic of More Info
Yoojin Kim
Contact
82222288131
[email protected]
Jihyun Choi
Contact
[email protected]
Joo Hang Kim, MD
Principal Investigator
Clinica Universidad Navarra
Pamplona Navarra, 31008, Spain More Info
Saoia Elizalde
Contact
+34948296397
[email protected]
Ignacio Gil Bazo, MD
Principal Investigator
Hospital Universitario 12 de Octubre
Alicante , 28007, Spain More Info
Sara Gomez
Contact
+34914692313
[email protected]
Carlos Gonzalez Maza
Contact
[email protected]
Luis Paz-Ares Rodriguez, MD
Principal Investigator
Hospital General Universitario de Alicante
Alicante , 3010, Spain More Info
Montserrat Garcia Araque
Contact
+34965933513
[email protected]
Bartomeu Massuti Sureda, MD
Principal Investigator
Hospital Universitario Vall d'Hebrón - PPDS
Barcelona , 0825, Spain More Info
Carmina Rodrigo
Contact
34932746085
[email protected]
Clara P Rambla
Contact
[email protected]
Alejandro Navarro Mendivil, MD
Principal Investigator
Clinica Universidad Navarra - Madrid
Madrid , 28027, Spain More Info
Myriam Martínez Moreno
Contact
+34 913531920
[email protected]
Ignacio Gil Bazo, MD
Principal Investigator
Hospital Universitario La Paz
Madrid , 28046, Spain More Info
Javier De Castro Carpeño, MD
Contact
Javier De Castro Carpeño, MD
Principal Investigator
Hospital Regional Universitario de Malaga - Hospital Civil
Málaga , 29011, Spain More Info
Daniel Garcia Garcia
Contact
+34951308130
[email protected]
Vanesa Gutierrez Calderon, MD
Principal Investigator
Hospital Universitario Virgen Macarena
Sevilla , 41071, Spain More Info
David Vicente Baz, MD
Contact
David Vicente Baz, MD
Principal Investigator
Hospital Universitari i Politecnic La Fe de Valencia
Valencia , 46026, Spain More Info
Oscar Jose Juan Vidal, MD
Contact
Oscar Jose Juan Vidal, MD
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 2

Estimated Enrollment:

38

Study ID:

NCT05027867

Recruitment Status:

Recruiting

Sponsor:


Kartos Therapeutics, Inc.

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.