Lung Cancer Clinical Trial
M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)
Summary
The main purpose of this study is to evaluate safety and efficacy in participants treated with concomitant chemoradiation therapy (cCRT) plus M7824 followed by M7824 compared to cCRT plus placebo followed by durvalumab.
Eligibility Criteria
Inclusion Criteria:
Participants must have histologically documented NSCLC who present with Stage III locally advanced, unresectable disease (International Association for the Study of Lung Cancer Staging Manual in Thoracic Oncology
Participants with tumor harboring an Epidermal growth factor receptor (EGFR) sensitizing (activating) mutation, Anaplastic lymphoma kinase (ALK) translocation, ROS-1 rearrangement are eligible.
Participants must have adequate pulmonary function defined as a forced expiratory volume in 1 second (FEV1) greater than equals to (>=) 1.2 liters or >= 50% of predicted normal volume measured within 3 weeks prior to randomization.
Adequate hematological, hepatic and renal function as defined in the protocol
Contraceptive use by males or females will be consistent with local regulations on contraception methods for those participating in clinical studies
Exclusion Criteria:
Participants with Mixed small cell with non-small cell lung cancer histology
Recent major surgery within 4 weeks prior to entry into the study
Significant acute or chronic infections including human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome, Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and active tuberculosis
Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization
Active autoimmune disease that has required systemic treatment in past 1 year (i.e., with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs)
Any prior systemic cytotoxic chemotherapy for their NSCLC or any antibody or drug targeting T-cell coregulatory proteins
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There are 21 Locations for this study
Orange California, 92868, United States
Santa Monica California, 90404, United States
Colorado Springs Colorado, 80909, United States
Fort Collins Colorado, 80528, United States
Boca Raton Florida, 33486, United States
Fort Lauderdale Florida, 33308, United States
Miami Florida, 33136, United States
Chicago Illinois, 60637, United States
Indianapolis Indiana, 46202, United States
Indianapolis Indiana, 46237, United States
Lexington Kentucky, 40503, United States
Baltimore Maryland, 21201, United States
Detroit Michigan, 48202, United States
Rochester Minnesota, 55902, United States
New York New York, 10032, United States
Nyack New York, 10960, United States
Pinehurst North Carolina, 28374, United States
Columbus Ohio, 43210, United States
Pittsburgh Pennsylvania, 15232, United States
Nashville Tennessee, 37232, United States
Houston Texas, 77030, United States
Cordoba , , Argentina
San Juan , , Argentina
Bendigo , , Australia
Douglas , , Australia
Elizabeth Vale , , Australia
Fitzroy , , Australia
Geelong , , Australia
Heidelberg Heights , , Australia
Pergamino , , Australia
Randwick , , Australia
St Albans , , Australia
St Leonards , , Australia
Warrnambool , , Australia
Leuven , , Belgium
Namur , , Belgium
Roeselare , , Belgium
Yvoir , , Belgium
Barretos , , Brazil
Itajaà , , Brazil
Porto Alegre , , Brazil
Porto Alegre , , Brazil
Rio de Janeiro , , Brazil
São Paulo , , Brazil
São Paulo , , Brazil
Kelowna , , Canada
Beijing , , China
Changchun , , China
Hangzhou , , China
Olomouc , , Czechia
Bayonne , , France
Marseille cedex 20 , , France
Paris Cedex 05 , , France
Saint Herblain , , France
Hamburg , , Germany
Oldenburg , , Germany
Bunkyo-ku , , Japan
Bunkyo-ku , , Japan
Hidaka-shi , , Japan
Kashiwa-shi , , Japan
Kobe-shi , , Japan
Koto-ku , , Japan
Kurume-shi , , Japan
Nagoya-shi , , Japan
Osaka-shi , , Japan
Osakasayama-shi , , Japan
Sunto-gun , , Japan
Yokohama-shi , , Japan
Daegu , , Korea, Republic of
Seongnam , , Korea, Republic of
Seoul , , Korea, Republic of
Seoul , , Korea, Republic of
Seoul , , Korea, Republic of
Seoul , , Korea, Republic of
's Hertogenbosch , , Netherlands
Amersfoort , , Netherlands
Breda , , Netherlands
Groningen , , Netherlands
Harderwijk , , Netherlands
Nieuwegein , , Netherlands
Tilburg , , Netherlands
Zwolle , , Netherlands
Barcelona , , Spain
Barcelona , , Spain
Barcelona , , Spain
L'Hospitalet de Llobregat , , Spain
Madrid , , Spain
Madrid , , Spain
Madrid , , Spain
Madrid , , Spain
Majadahonda , , Spain
Málaga , , Spain
Pamplona , , Spain
Santiago de Compostela , , Spain
Sevilla , , Spain
Sevilla , , Spain
Sevilla , , Spain
Valencia , , Spain
Valencia , , Spain
Vigo , , Spain
Taichung , , Taiwan
Tainan , , Taiwan
Taipei , , Taiwan
Taipei , , Taiwan
How clear is this clinincal trial information?
Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.