This prospective, observational study will evaluate whether vitro testing of tumor tissue and white blood cells from patients with lung cancer who are being treated with immune checkpoint inhibitors and other standard of care approaches, predicts clinical response to these agents.
Overall Goal: The long-term goal of this study is to predict whether checkpoint inhibitors will be effective in individual patients with solid tumors.
Objectives: In this pilot study to be conducted in ten subjects with lung cancer who are to receive checkpoint inhibitors, we will use cellular and molecular techniques to characterize
tumor immunogenicity anti-tumor T-cell response effect of checkpoint inhibitors on antigen presentation and T-cell response, and the tumor microenvironment
Planned enrollment:
• Ten subjects with lung cancer
Methods for Informed Consent:
Investigators will approach subjects for informed consent
Subjects with lung cancer about to undergo diagnostic/excisional biopsy with the intent to receive therapy with immune checkpoint inhibitors Availability of fresh tumor tissue removed at excisional biopsy or diagnostic biopsy Informed consent
