Lung Cancer Clinical Trial

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Summary

This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
Candidacy to receive treatment with docetaxel.

Crossover Inclusion Criteria:

Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
ECOG performance status 0-2

Exclusion Criteria:

Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
Active brain metastases.

Crossover Exclusion Criteria:

Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

450

Study ID:

NCT04685135

Recruitment Status:

Recruiting

Sponsor:

Mirati Therapeutics Inc.

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There are 33 Locations for this study

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Duarte California, 91010, United States
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Long Beach California, 90813, United States
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Santa Rosa California, 95403, United States
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Whittier California, 90603, United States
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Grand Junction Colorado, 81502, United States
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Lafayette Colorado, 80026, United States
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Lone Tree Colorado, 80124, United States
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Fort Lauderdale Florida, 33308, United States
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Jacksonville Florida, 32204, United States
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Jacksonville Florida, 32256, United States
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Miami Beach Florida, 33140, United States
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Orlando Florida, 32806, United States
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Plantation Florida, 33322, United States
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Athens Georgia, 30607, United States
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Marietta Georgia, 30060, United States
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Chicago Illinois, 60612, United States
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Chicago Illinois, 60637, United States
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Goshen Indiana, 46526, United States
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Indianapolis Indiana, 46237, United States
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Westwood Kansas, 66205, United States
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Wichita Kansas, 67214, United States
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New Orleans Louisiana, 70112, United States
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Scarborough Maine, 04074, United States
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Frederick Maryland, 21702, United States
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Billings Montana, 59102, United States
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East Brunswick New Jersey, 08816, United States
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Teaneck New Jersey, 07666, United States
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Syracuse New York, 13210, United States
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Cleveland Ohio, 44106, United States
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Kettering Ohio, 45429, United States
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Salem Oregon, 97301, United States
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Providence Rhode Island, 02903, United States
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Irving Texas, 75063, United States
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Bedford Park , , Australia
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Douglas , , Australia
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Mackay , , Australia
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Saint Leonards , , Australia
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Wollongong , , Australia
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Woolloongabba , , Australia
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Klagenfurt , , Austria
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Salzburg , , Austria
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Brussels , , Belgium
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Charleroi , , Belgium
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Edegem , , Belgium
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Gent , , Belgium
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Hasselt , , Belgium
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Roeselare , , Belgium
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Ronse , , Belgium
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Yvoir , , Belgium
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Beijing , , China
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Changchun , , China
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Changsha , , China
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Chengdu , , China
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Chongqing , , China
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Fuzhou , , China
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Guangxi , , China
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Guangzhou , , China
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Hangzhou , , China
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Harbin , , China
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Jinan , , China
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Linyi , , China
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Nanchang , , China
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Nanjing , , China
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Qingdao , , China
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Shanghai , , China
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Shenyang , , China
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Wuhan , , China
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Xiamen , , China
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Xinxiang , , China
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Xuzhou , , China
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Zhengzhou , , China
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Hořovice , , Czechia
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Olomouc , , Czechia
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Prague , , Czechia
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Praha 2 , , Czechia
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Brest , , France
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Bron , , France
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Caen , , France
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Créteil , , France
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Dijon Cedex , , France
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Gleizé , , France
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La Tronche , , France
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Limoges cedex , , France
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Marseille , , France
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Montpellier , , France
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Mulhouse , , France
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Nice , , France
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Quimper , , France
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Saint Herblain , , France
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Saint-Priest-en-Jarez , , France
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Strasbourg , , France
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Tours Cedex 9 , , France
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Villejuif , , France
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München Bayern, , Germany
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Bad Berka , , Germany
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Bonn , , Germany
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Essen , , Germany
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Gauting , , Germany
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Gießen , , Germany
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Großhansdorf , , Germany
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Halle (Saale) , , Germany
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Jena , , Germany
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Kassel , , Germany
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Köln , , Germany
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Löwenstein , , Germany
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Lübeck , , Germany
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Offenbach , , Germany
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Oldenburg , , Germany
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Athens , , Greece
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Heraklion , , Greece
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Larissa , , Greece
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Néa Kifisiá , , Greece
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Néo Fáliro , , Greece
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Thessaloníki , , Greece
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Volos , , Greece
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Kowloon , , Hong Kong
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Shatin , , Hong Kong
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Budapest , , Hungary
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Gyula , , Hungary
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Gyöngyös , , Hungary
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Székesfehérvár , , Hungary
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Törökbálint , , Hungary
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Dublin , , Ireland
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Galway , , Ireland
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Limerick , , Ireland
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Alessandria , , Italy
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Avellino , , Italy
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Aviano , , Italy
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Bari , , Italy
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Brescia , , Italy
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Candiolo , , Italy
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Catania , , Italy
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Firenze , , Italy
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Genova , , Italy
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Lecce , , Italy
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Meldola , , Italy
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Milano , , Italy
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Milan , , Italy
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Napoli , , Italy
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Novara , , Italy
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Parma , , Italy
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Perugia , , Italy
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Pesaro , , Italy
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Ravenna , , Italy
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Roma , , Italy
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Busan , , Korea, Republic of
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Cheongju-si , , Korea, Republic of
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Daegu , , Korea, Republic of
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Hwasun , , Korea, Republic of
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Incheon , , Korea, Republic of
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Seongnam-si , , Korea, Republic of
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Seoul , , Korea, Republic of
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Suwon-si , , Korea, Republic of
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Amsterdam , , Netherlands
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Breda , , Netherlands
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Den Haag , , Netherlands
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Nieuwegein , , Netherlands
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Nijmegen , , Netherlands
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Lublin Lubelskie, , Poland
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Lublin , , Poland
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Otwock , , Poland
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Rzeszów , , Poland
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Skorzewo , , Poland
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Toruń , , Poland
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Warszawa , , Poland
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Łódź , , Poland
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Almada , , Portugal
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Braga , , Portugal
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Coimbra , , Portugal
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Guimarães , , Portugal
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Lisboa , , Portugal
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Lisbon , , Portugal
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Porto , , Portugal
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Santa Maria Da Feira , , Portugal
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Setúbal , , Portugal
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Vila Nova De Gaia , , Portugal
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Baia Mare , , Romania
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BraÅŸov , , Romania
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Bucharest , , Romania
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Bucuresti , , Romania
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Cluj-Napoca , , Romania
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Craiova , , Romania
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IaÅŸi , , Romania
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TimiÅŸoara , , Romania
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Chelyabinsk , , Russian Federation
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Izhevsk , , Russian Federation
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Kursk , , Russian Federation
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Moscow , , Russian Federation
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Nizhniy Novgorod , , Russian Federation
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Novosibirsk , , Russian Federation
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Omsk , , Russian Federation
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Saint Petersburg , , Russian Federation
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Saint-Petersburg , , Russian Federation
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Singapore , , Singapore
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A Coruña , , Spain
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Alicante , , Spain
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Badalona , , Spain
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Barakaldo , , Spain
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Barcelona , , Spain
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Cordoba , , Spain
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Girona , , Spain
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Granada , , Spain
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León , , Spain
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Lugo , , Spain
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Madrid , , Spain
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Malaga , , Spain
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Palma De Mallorca , , Spain
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Santander , , Spain
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Sevilla , , Spain
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Valencia , , Spain
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Zaragoza , , Spain
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Basel , , Switzerland
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Thun , , Switzerland
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Winterthur , , Switzerland
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Birmingham , , United Kingdom
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Edinburgh , , United Kingdom
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Glasgow , , United Kingdom
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Leicester , , United Kingdom
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Manchester , , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

450

Study ID:

NCT04685135

Recruitment Status:

Recruiting

Sponsor:


Mirati Therapeutics Inc.

How clear is this clinincal trial information?

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