Lung Cancer Clinical Trial

Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Summary

This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically or cytologically confirmed diagnosis of NSCLC with KRAS G12C mutation.
Candidacy to receive treatment with docetaxel.

Crossover Inclusion Criteria:

Evidence of RECIST 1.1 defined disease progression on docetaxel per BICR
ECOG performance status 0-2

Exclusion Criteria:

Prior treatment with an agent targeting KRAS G12C (e.g., AMG 510, Sotorasib).
Active brain metastases.

Crossover Exclusion Criteria:

Receipt of any other systemic anti-cancer therapy after last administration of docetaxel on the study.

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

340

Study ID:

NCT04685135

Recruitment Status:

Recruiting

Sponsor:

Mirati Therapeutics Inc.

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 32 Locations for this study

See Locations Near You

Research Site
Duarte California, 91010, United States
Research Site
Long Beach California, 90813, United States
Research Site
Santa Rosa California, 95403, United States
Research Site
Whittier California, 90603, United States
Research Site
Grand Junction Colorado, 81502, United States
Research Site
Lafayette Colorado, 80026, United States
Research Site
Lone Tree Colorado, 80124, United States
Research Site
Fort Lauderdale Florida, 33308, United States
Research Site
Jacksonville Florida, 32204, United States
Research Site
Jacksonville Florida, 32256, United States
Research Site
Miami Beach Florida, 33140, United States
Research Site
Orlando Florida, 32806, United States
Research Site
Plantation Florida, 33322, United States
Research Site
Athens Georgia, 30607, United States
Research Site
Marietta Georgia, 30060, United States
Research Site
Chicago Illinois, 60612, United States
Research Site
Chicago Illinois, 60637, United States
Research Site
Goshen Indiana, 46526, United States
Research Site
Indianapolis Indiana, 46237, United States
Research Site
Westwood Kansas, 66205, United States
Research Site
Wichita Kansas, 67214, United States
Research Site
New Orleans Louisiana, 70112, United States
Research Site
Scarborough Maine, 04074, United States
Research Site
Frederick Maryland, 21702, United States
Research Site
Billings Montana, 59102, United States
Research Site
East Brunswick New Jersey, 08816, United States
Research Site
Syracuse New York, 13210, United States
Research Site
Cleveland Ohio, 44106, United States
Research Site
Kettering Ohio, 45429, United States
Research Site
Salem Oregon, 97301, United States
Research Site
Providence Rhode Island, 02903, United States
Research Site
Irving Texas, 75063, United States
Research Site
Bedford Park , , Australia
Research Site
Saint Leonards , , Australia
Research Site
Woolloongabba , , Australia
Research Site
Klagenfurt , , Austria
Research Site
Salzburg , , Austria
Research Site
Brussels , , Belgium
Research Site
Charleroi , , Belgium
Research Site
Gent , , Belgium
Research Site
Roeselare , , Belgium
Research Site
Ronse , , Belgium
Research Site
Yvoir , , Belgium
Research SIte
Hořovice , , Czechia
Research Site
Olomouc , , Czechia
Research Site
Prague , , Czechia
Research Site
Praha 2 , , Czechia
Research Site
Brest , , France
Research Site
Bron , , France
Research Site
Caen , , France
Research Site
Créteil , , France
Research Site
Dijon Cedex , , France
Research Site
Gleizé , , France
Research Site
La Tronche , , France
Research Site
Limoges cedex , , France
Research Site
Marseille , , France
Research Site
Montpellier , , France
Research Site
Mulhouse , , France
Research Site
Quimper , , France
Research Site
Saint Herblain , , France
Research Site
Strasbourg , , France
Research Site
Villejuif , , France
Research Site
München Bayern, , Germany
Research Site
Bad Berka , , Germany
Research Site
Bonn , , Germany
Research Site
Essen , , Germany
Research site
Gauting , , Germany
Research Site
Gießen , , Germany
Research Site
Großhansdorf , , Germany
Research Site
Halle (Saale) , , Germany
Research Site
Jena , , Germany
Research Site
Kassel , , Germany
Research Site
Löwenstein , , Germany
Research Site
Lübeck , , Germany
Research Site
Offenbach , , Germany
Research Site
Oldenburg , , Germany
Research Site
Athens , , Greece
Research Site
Heraklion , , Greece
Research Site
Larissa , , Greece
Research Site
Néa Kifisiá , , Greece
Research Site
Néo Fáliro , , Greece
Research Site
Thessaloníki , , Greece
Research Site
Volos , , Greece
Research Site
Kowloon , , Hong Kong
Research Site
Shatin , , Hong Kong
Research Site
Budapest , , Hungary
Research Site
Gyöngyös , , Hungary
Research Site
Székesfehérvár , , Hungary
Research Site
Törökbálint , , Hungary
Research Site
Dublin , , Ireland
Research Site
Galway , , Ireland
Research Site
Alessandria , , Italy
Research Site
Avellino , , Italy
Research Site
Candiolo , , Italy
Research Site
Catania , , Italy
Research Site
Genova , , Italy
Research Site
Lecce , , Italy
Research Site
Meldola , , Italy
Research Site
Milano , , Italy
Research Site
Napoli , , Italy
Research Site
Parma , , Italy
Research Site
Perugia , , Italy
Research Site
Roma , , Italy
Research Site
Busan , , Korea, Republic of
Research Site
Cheongju-si , , Korea, Republic of
Research Site
Daegu , , Korea, Republic of
Research Site
Hwasun , , Korea, Republic of
Research Site
Incheon , , Korea, Republic of
Research Site
Seongnam-si , , Korea, Republic of
Research Site
Seoul , , Korea, Republic of
Research Site
Suwon-si , , Korea, Republic of
Research Site
Lublin Lubelskie, , Poland
Research Site
Lublin , , Poland
Research Site
Otwock , , Poland
Research Site
Rzeszów , , Poland
Research Site
Skorzewo , , Poland
Research Site
Toruń , , Poland
Research Site
Warszawa , , Poland
Research Site
Łódź , , Poland
Research Site
Braga , , Portugal
Research Site
Coimbra , , Portugal
Research Site
Guimarães , , Portugal
Research Site
Lisboa , , Portugal
Research Site
Lisbon , , Portugal
Research Site
Porto , , Portugal
Research Site
Vila Nova De Gaia , , Portugal
Research Site
Chelyabinsk , , Russian Federation
Research Site
Izhevsk , , Russian Federation
Research Site
Kursk , , Russian Federation
Research Site
Moscow , , Russian Federation
Research Site
Nizhniy Novgorod , , Russian Federation
Research Site
Novosibirsk , , Russian Federation
Research Site
Omsk , , Russian Federation
Research Site
Saint Petersburg , , Russian Federation
Research Site
Saint-Petersburg , , Russian Federation
Research Site
Singapore , , Singapore
Research Site
A Coruña , , Spain
Research Site
Alicante , , Spain
Research Site
Badalona , , Spain
Research Site
Barcelona , , Spain
Research Site
Cordoba , , Spain
Research Site
Girona , , Spain
Research Site
Granada , , Spain
Research Site
Lugo , , Spain
Research Site
Madrid , , Spain
Research Site
Malaga , , Spain
Research Site
Palma De Mallorca , , Spain
Research Site
Santander , , Spain
Research Site
Sevilla , , Spain
Research Site
Valencia , , Spain
Research Site
Zaragoza , , Spain
Research Site
Basel , , Switzerland
Research Site
Thun , , Switzerland
Research Site
Winterthur , , Switzerland
Research Site
Birmingham , , United Kingdom
Research Site
Edinburgh , , United Kingdom
Research Site
Glasgow , , United Kingdom
Research Site
Leicester , , United Kingdom
Research Site
Manchester , , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

340

Study ID:

NCT04685135

Recruitment Status:

Recruiting

Sponsor:


Mirati Therapeutics Inc.

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.