Lung Cancer Clinical Trial

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Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer

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Summary

The purpose of this study is to determine the maximum tolerated dose (MTD) of vorinostat given concurrently with stereotactic radiosurgery (SRS) to treat non-small cell lung cancer (NSCLCA) brain metastases in patient with 1-4 lesions.

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Eligibility Criteria

Inclusion Criteria:

All patients age 18 years and older with histologically proven non-small cell lung cancer and 1-4 brain metastases, each measuring less than 2 cm will be eligible. Prior surgery or radiation is allowed as long as the target metastatic lesion(s) has not been treated with previous radiation.
Adequate organ function (section 3.1.10).
ECOG performance status 0-2.
Life expectancy of >=12 weeks.
Systemic chemotherapy washout period >=7 days.

Exclusion Criteria:

Patients who have previously been treated with whole brain irradiation, pediatric patients (age <18), pregnant women, and patients who are unable to give informed consent.

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

17

Study ID:

NCT00946673

Recruitment Status:

Completed

Sponsor:

Stanford University

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There are 2 Locations for this study

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Stanford University School of Medicine
Stanford California, 94305, United States
Moffitt Cancer Center
Tampa Florida, 33612, United States

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 1

Estimated Enrollment:

17

Study ID:

NCT00946673

Recruitment Status:

Completed

Sponsor:


Stanford University

How clear is this clinincal trial information?

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