Lung Cancer Clinical Trial
Picoplatin as Second-Line Therapy for Patients With Small Cell Lung Cancer
Summary
This is a Phase II research study that is designed for patients who have small cell lung cancer (SCLC) that is no longer responding to treatment. Patients will receive picoplatin, a new platinum-based agent that is currently under investigation, in 21-day cycles.
Full Description
Platinum drugs work by binding to DNA and preventing the rapid cell division of tumors. However, many tumors demonstrate a resistance to platinum drugs. Results from preclinical studies indicate that picoplatin (previously called AMD473 or ZD0473) may be able to overcome or partially overcome platinum resistance. More than 500 patients have received picoplatin in previous Phase I or Phase II clinical trials.
Eligibility Criteria
Main inclusion criteria:
Diagnosis of small cell lung cancer.
Patients must have had one prior chemotherapy regimen which must have included either cisplatin or carboplatin.
[Additional eligibility criteria apply.]
Exclusion Criteria:
Prior radiotherapy that included > 30% of the bone marrow (i.e., the whole of the pelvis or half of the spine).
Significant chronic or recent acute gastrointestinal disorder with diarrhea as a major symptom.
Significant heart disease.
Uncontrolled, untreated, unstable, or symptomatic brain tumors or central nervous system disease.
Grade 2+ peripheral neuropathy (a condition caused by damage to the nerves in the peripheral nervous system).
[Additional exclusion criteria apply.]
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There are 29 Locations for this study
Hot Springs Arkansas, 71913, United States
Los Angeles California, , United States
Palm Springs California, 92262, United States
Norwich Connecticut, 06360, United States
Miami Florida, 33176, United States
Tampa Florida, 33612, United States
Augusta Georgia, 30901, United States
Macon Georgia, 31201, United States
Tucker Georgia, 30084, United States
Chicago Illinois, 60612, United States
Vincennes Indiana, 47591, United States
Kansas City Kansas, 66160, United States
Lexington Kentucky, 40536, United States
New Orleans Louisiana, 70121, United States
Shreveport Louisiana, 71130, United States
Columbia Missouri, 65203, United States
St. Louis Missouri, 63141, United States
Billings Montana, 59101, United States
Reno Nevada, 89502, United States
Lebanon New Hampshire, 03756, United States
New York New York, 10029, United States
Goldsboro North Carolina, 27534, United States
Portland Oregon, 97213, United States
Drexel Hill Pennsylvania, 19026, United States
Columbia South Carolina, 29210, United States
Memphis Tennessee, 38120, United States
Nashville Tennessee, 37232, United States
Austin Texas, 78705, United States
Calgary Alberta, T2N 4, Canada
Toronto Ontario, M5G 2, Canada
Stepanovskoye, Krasnogorskiy District Moscow Region, , Russian Federation
Ufa Republic of Bashkortostan, , Russian Federation
Petrozavodsk Republic of Karelia, , Russian Federation
Kazan Republic of Tatarstan, , Russian Federation
Izhevsk Republic of Udmurtia, , Russian Federation
Engels Saratov Region, , Russian Federation
Cherepovets Vologodskaya Region, , Russian Federation
Astrakhan , , Russian Federation
Barnaul , , Russian Federation
Chelyabinsk , , Russian Federation
Ekaterinburg , , Russian Federation
Kaliningrad , , Russian Federation
Krasnodar , , Russian Federation
Moscow , , Russian Federation
Nizhny Novgorod , , Russian Federation
Omsk , , Russian Federation
Orenburg , , Russian Federation
Pyatigorsk , , Russian Federation
Rostov-na-Donu , , Russian Federation
Samara , , Russian Federation
St. Petersburg , , Russian Federation
Stavropol , , Russian Federation
Ulyanovsk , , Russian Federation
Voronezh , , Russian Federation
Yaroslavl , , Russian Federation
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