Safety of Lung Cryobiopsy in People With Cancer

Inclusion Criteria:

18 years of age or greater
Patients with known or suspected diagnosis of cancer and indeterminant pulmonary nodules or diffuse parenchymal lung disease with non-diagnostic clinical profiles for whom a lung biopsy is deemed useful for diagnosis.

Exclusion Criteria:

Patients with pulse oximetry less than 92% on oxygen delivery up to 2 L nasal cannula.

Uncorrectable coagulopathy defined as:

Platelet count <50,000 x 10^9/L or
prothrombin time international normalized ratio >1.5
FVC <50% of the predicted value, DLCO <30% of the predicted value or FEV1 <0.8L
Known pulmonary hypertension or echocardiographic pulmonary artery systolic pressure >50mmHg
A secure diagnosis based on clinical and high-resolution CT scan data.
Antiplatelet therapy that cannot be held for more than 5 days.
Any patient deemed unfit to undergo bronchoscopy by the proceduralist
Female patients with a positive pregnancy test within 30 days of the planned study procedure