Lung Cancer Clinical Trial
Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis
Summary
This phase II trial investigates how stereotactic radiosurgery affects brain functions while treating patients with small cell lung cancer that has spread to the brain (brain metastasis). Standard of care treatment consists of whole brain radiation therapy, which targets the entire brain, and may result in side effects affecting the nervous system. Stereotactic radiosurgery only targets areas of the brain that are suspected to be affected by the disease. The purpose of this trial is to learn if and how patients' brain functions are affected by the use of stereotactic radiosurgery rather than whole brain radiation therapy in managing brain metastasis caused by small cell lung cancer. Stereotactic radiosurgery may help patients avoid nervous system side effects caused by whole brain radiation therapy.
Full Description
PRIMARY OBJECTIVE:
I. To estimate the cognitive decline rate at 3 months.
SECONDARY OBJECTIVES:
I. To examine cognitive decline rate on each individual cognitive test at each time point.
II. To examine cognitive decline rates using reliable change index methodology. III. To report the overall survival of patients (death due to any cause) of patients receiving stereotactic radiosurgery (SRS) for small cell lung cancer (SCLC) brain metastasis.
IV. To report rates of local tumor control (of the treated lesions) in the brain post-treatment, as dictated by magnetic resonance imaging (MRI) surveillance schedule above.
V. To report distant tumor control in the brain (of non-treated lesions) post-treatment, as dictated by MRI surveillance schedule above.
VI. To report time elapsed from SRS to whole brain radiation therapy (WBRT). VII. To report rate of intracranial toxicity of SRS in the setting of prior WBRT.
VIII. To report rates of intracranial toxicity of concurrent atezolizumab with SRS.
IX. To determine rates of systemic and intracranial disease control (time to progression) in those who are treated concurrently with atezolizumab and SRS.
X. To determine the rates of SCLC-specific survival. XI. To assess the pre-treatment factors and baseline characteristics in the predictive determination of local control, intracranial control, systemic control, and neurocognitive outcomes.
XII. To assess the correlation between number of lesions and total volume of intracranial disease and neurocognitive outcome.
XIII. To document post-treatment intracranial toxicity profile in patients after SRS.
CORRELATIVE OBJECTIVE:
I. Cerebral spinal fluid (CSF) biomarkers.
OUTLINE:
Patients undergo SRS in the absence of disease progression or unacceptable toxicity. Patients whose disease progresses may be treated with additional courses of SRS per physician discretion.
After completion of study treatment, patients are followed up at 1, 3, 6, 9, 12, 16, 20, 24, 30, and 36 months after SRS.
Eligibility Criteria
Inclusion Criteria:
Patients must have Eastern Cooperative Oncology Group (ECOG) =< 3
All patients must have histologic evidence suggesting small cell lung cancer. Histologic confirmation may be from the primary tumor site, or from another metastatic site (systemic lymph node, etc.). Cytology-alone is not an acceptable method of diagnosis.
Patient has 5 or less brain metastases on contrast-enhanced brain MRI scan obtained no greater than 6 weeks prior to study registration. Biopsy of brain metastasis is not required. A patient may be enrolled with zero brain metastasis assuming that the SRS is to be directed at the postoperative surgical cavity of a resected metastasis
Patients must be eligible to have all lesions treated with stereotactic radiosurgery as determined by the study radiation oncologist
Patients must sign informed consent indicating that they are aware of the investigational nature of this study in keeping with the policies of the hospital
Patients should have normal coagulation (international normalized ratio [INR] < 1.3) and be able to withhold anticoagulation/antiplatelet medications a minimum of 24 hours prior to radiosurgery treatment (or until INR normalizes), on the day of treatment and 24 hours after radiosurgery treatment has concluded
Patient's primary language is English
Standard ECOG performance status assessment will be used and determined by the treating physician
Exclusion Criteria:
Patients are excluded if they have a history of metastatic cancer in addition to small cell malignancy or a history of uncontrolled non-metastatic cancer. Patients with localized squamous cell carcinoma and/or basal cell carcinoma are not excluded
Patients are excluded if there is radiographic evidence of leptomeningeal disease
Patients are excluded if there are malignant cells identified in the CSF on cytologic examination
Patients are not excluded for circulating tumor deoxyribonucleic acid (DNA) (ctDNA) found in the CSF
Female patients of childbearing age are excluded if they are pregnant as determined with a urine or serum beta human chorionic gonadotropin (HCG) no greater than 14 days prior to study registration, or breast-feeding
Patients are excluded if they are unable to obtain an MRI scan for any other reason, including gadolinium allergy
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There is 1 Location for this study
Houston Texas, 77030, United States More Info
Principal Investigator
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